<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28364

Description Mediator of RNA polymerase II transcription subunit 19
SequenceMSCRVELSAEPKGREVGMPIGRRDDFRTMPRLEPGSVKAGRSVVSPHVEVDCHCRGARGGHEDSTLGFRYKLTLLTLAGRVTQCSAENLWRCVALLAGEWPCSPSRLWLKGQGRPTLPSIPARLQVQAHSVNGSSLANDMSFTDIVMGENSPQKRKRTSDDVGDREQKKVHIEDRKLGIDDLHLDVGEKYLFCRSRKAPFTCTQKKKKQQQQQRRRRRQWHMQEKRSRSLWLMLPQRRALSLEHQPPRPHLSEDLFEMYGLADLAAEYARIKDGQKNALRKTYKGHIKKLGVQGHFDSVKTDEKDPERLEYLMGCPQEEWNAHFVRGKEITRGLSSDMKSKISRAVTMSRGAVPSTLWNNSVLGDIAASSMKAHLNQPPSARPTAPNTPLAYGGPAMQRVKPQTPGFQDNRPRRNIKKRGYGDSSFEGYGEGFEDDGGLETGYSTGEGDMASGLKRRKKVLIGSNVPG
Length468
PositionHead
OrganismNeurospora tetrasperma (strain FGSC 2509 / P0656)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Sordariomycetidae> Sordariales> Sordariaceae> Neurospora.
Aromaticity0.06
Grand average of hydropathy-0.825
Instability index58.20
Isoelectric point9.80
Molecular weight52524.20
Publications
PubMed=21750257

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364151
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP28364
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      92.45|      26|      26|     271|     296|       1
---------------------------------------------------------------------------
  271-  296 (44.27/26.82)	IKDGQKNALRKTYKGHIKKLGVQGHF
  299-  324 (48.18/29.77)	VKTDEKDPERLEYLMGCPQEEWNAHF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.17|      13|      16|      77|      90|       3
---------------------------------------------------------------------------
   77-   90 (21.77/15.94)	LAGRvTQCSAENLW
   96-  108 (29.39/17.33)	LAGE.WPCSPSRLW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     108.20|      23|      24|     401|     423|       4
---------------------------------------------------------------------------
  377-  397 (29.93/15.63)	..QPPSARPTAPNTPLAYGGPAM
  401-  423 (40.95/24.27)	KPQTPGFQDNRPRRNIKKRGYGD
  427-  449 (37.32/21.42)	EGYGEGFEDDGGLETGYSTGEGD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.00|      17|      18|     160|     176|       5
---------------------------------------------------------------------------
  160-  176 (29.79/21.68)	DDVG.DREQKKVHIEDRK
  180-  197 (27.21/19.14)	DDLHlDVGEKYLFCRSRK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28364 with Med19 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ASSMKAHLNQPPSARPTAPNTPLAYGGPAMQRVKPQTPGFQDNRPRRNIKKRGYGDSSFEGYGEGFEDDGGLETGYSTGEGDMASGLKRRKKVLIGSNVPG
368
468










Molecular Recognition Features






MoRF SequenceStartStop




1) DMASGLKRRKKVLIGSNVPG
449
468