<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28362

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMELAQAFEFFSTLIPLWVLGSCRLTVMWKVRLVFARYTTNIVNQSSTFSRLEPRRPWADHNGERATSSPDIVRARSLLLYHSLSLPSTIPVSNAPTMPGGPATAGLSAAVGQWTKFLARAEAKRLDPSDFARFVPILNSDFYPLPPIVIANLLLKPTKQSSYSLDPRRLQYLTILLNQKLVNPQSVLKVLHHYSTSQAKIQSEYDASTTNVAATATKGGQGQQGDKKPKRVFWQNSYNDEEVIFLRLSKVITHGQGIRHASDAYEMATNLSKWTTLFIDVIAAFSRDTFGTIQNMRTKQDMETSLQAFSLLLVNFLGNQRVVSAFSRPEAKSHRKGLASSIDQLIPYLLQNPNTSGIAERLEFSRGQALAGEESSDLKDAAVAEMHSYMDNMIGLDTWQIPDMPIVNSRAGLYIYINAALVGRPLIDDHSLYTYLHNRYQGDLQTTAIHLILASFDVLANAVFREGSKTGHLLKSYVVNKVPLILGNFAASSTHMYPFDAEFCISQALGQVDTNVFPTLSNMFDMSNTSSSFQDSVRQDFCFACQLHGLLSASAIETLLGEITYQTLPDEGRYVKETLVQACLEDFERSQRLIGELDNMNGNVGAAAQAIVEVIGTLCRNKETMTLKQLCSQLASKPSSLDILLLFDKPYKILHPLCELLDDWGGYDEDQGEYQPVYEEFGSIQLLLLAFVHRYSLTPTDLAIRSPHSFVGKLLGRGQLSRPLDELSDQEKSHLNGWVHGLFDSEAGGLGDDLMSSCPPQDFYLLMPTLFDQIVMALSTGCLNDYLLRSGLELPALLFLANNLRTDKQPGQGAVIKILQLILRPNSISNEASTMLSSVLNIVAKPLELSLRSYQRQVPASQEVEPLLRALKENLAVSSRTGGADHSELENWTGTHHNGSGSVGGLYGAIRHTVQNLVQWAQHSPGNGVPATYTHRQVLVALQICGARRLLSALLKELKTQTEAGNGSVAYDVVTAIICAPDVHNTPVTDDNDPSSAREGGDAANHPITKKQRRITLREALKFEAEEFKKIQKSDPLMAETVVRLHRRVEAQMALPPPPPPPAQHHHHHQQTMLQPELSALGVVAGDAMGDSIMNAAAVQVSGSDHHHPMDAMSLDATGMGGLDVGGAGGIDISGMGDMGMGNMGGLTVNTNTGGGMGGGVGTGGQGGGVAGGGGAGASGGNGGGGGAGGAGGGGSGSGGAGGDLSGDDIFSGLGTGDFTTDFGNWDTMDLG
Length1231
PositionTail
OrganismNeurospora tetrasperma (strain FGSC 2509 / P0656)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Sordariomycetidae> Sordariales> Sordariaceae> Neurospora.
Aromaticity0.07
Grand average of hydropathy-0.163
Instability index39.09
Isoelectric point5.73
Molecular weight132787.74
Publications
PubMed=21750257

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364142
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP28362
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     231.42|      36|      36|    1136|    1171|       1
---------------------------------------------------------------------------
 1072- 1102 (38.29/14.01)	..M..LQPELSALGV..VAGDA.....MGDSI.MNAAAV.QVSG
 1103- 1134 (50.45/20.69)	SDH...HHPMDAMSLDA...TG.....M.GGLDVGGAGGiDISG
 1136- 1171 (69.37/31.10)	GDM..GMGNMGGLTVNTNTGGG.....MGGGVGTGGQGG.GVAG
 1173- 1206 (48.82/19.80)	G....GAGASGG.....NGGGGgaggaGGGGSGSGGAGG.DLSG
 1207- 1231 (24.49/ 6.41)	DDIfsGLGT.GDFTTDFGNWDT.....MDLG.............
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     114.64|      32|      36|     905|     940|       2
---------------------------------------------------------------------------
  879-  903 (24.16/ 9.43)	RTGGADHS..ELEN..WtGTHHNGSGsVG...........
  905-  940 (48.60/42.07)	LYGAIRHTVQNLVQ..W.AQHSPGNG.VPAtYthrQVLVA
  943-  975 (41.88/24.37)	ICGA.RRLLSALLKelK.TQTEAGNG.SVA.Y...DVVTA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.70|      10|      32|     747|     756|       3
---------------------------------------------------------------------------
  747-  756 (18.96/11.68)	GGLGDDLMSS
  780-  789 (19.75/12.54)	GCLNDYLLRS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.70|      22|      26|     814|     839|       4
---------------------------------------------------------------------------
  814-  835 (36.20/20.20)	VIKILQLILRPN....SISNEASTML
  842-  867 (31.50/10.09)	VAKPLELSLRSYqrqvPASQEVEPLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.27|      15|      32|     265|     279|       5
---------------------------------------------------------------------------
  265-  279 (26.29/16.98)	EMATNLSKWTTLFID
  300-  314 (23.97/14.84)	DMETSLQAFSLLLVN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      94.23|      30|      36|     479|     509|       6
---------------------------------------------------------------------------
  479-  509 (50.64/37.81)	NKVPLILGNFAASSTHMyPF.DA...EFCISQAL.G
  514-  548 (43.60/26.79)	NVFPTLSNMFDMSNTSS.SFqDSvrqDFCFACQLhG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.29|      17|      26|     617|     633|       7
---------------------------------------------------------------------------
  617-  633 (30.40/20.57)	LCRNKETMTLKQLCSQL
  644-  660 (30.89/21.02)	LLFDKPYKILHPLCELL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     119.95|      37|      40|     125|     162|      12
---------------------------------------------------------------------------
  125-  162 (61.71/46.44)	LDPSDFARFVPILNSDFYPlPPIVIANLLLKPTK....QSSY
  164-  204 (58.24/38.91)	LDPRRLQYLTILLNQKLVN.PQSVLKVLHHYSTSqakiQSEY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.26|      12|      17|     404|     416|      13
---------------------------------------------------------------------------
  404-  416 (17.70/15.85)	PIVNSRaGLYIYI
  424-  435 (22.55/14.79)	PLIDDH.SLYTYL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28362 with Med5 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DVHNTPVTDDNDPSSAREGGDAANHPITKKQRRIT
2) GNMGGLTVNTNTGGGMGGGVGTGGQGGGVAGGGGAGASGGNGGGGGAGGAGGGGSGSGGAGGDLSGDDIFSGL
3) LHRRVEAQMALPPPPPPPAQHHHHHQQTMLQPELSALG
981
1141
1044
1015
1213
1081










Molecular Recognition Features






MoRF SequenceStartStop




NANANA