<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28359

Description Mediator of RNA polymerase II transcription subunit 12
SequenceMATIAAITYSDTPPPVIPTITQRVSVTTQIVAITKGTNFGTKDDCSTRTVELDLLGANLQFQIPDSIQTPDRLLRLCTSQTTSFLKSVLNPSSTETTSTRLQLDPDRDRFPYPPSPPTDDLRNGASAPPPAMTSRPPLGVQQRQPQQRKLSGPVLSQQRSLSQSQAQAQAQQQQPHLHTQQQQQQQQQQYDASSYLPPPPPAPTRNNNHNNFTNQNNTLNNAFPPELAQQDPTSIVSPADPSGSSPALSVGVGRYGTQRRGGSRLRLELSHNDPSDAFSSPTVIESPGLVEPHTQYGSLTHLMMPLADGPDLGDMSPHHRLSIPPQHLDADVPIPFPQRRPKAVPDHSRREQAPPPPNPARKDTRPKPYTIELPAAAPRYRIRGRSDGQGGQGRSSALATASSSSTTGSSATANYGCADFFPWSGTAGNHPEDQFNDTAIRVGYSEKQFVTPETQSAKTVLFHGLKQRSGLNALSIFFAGVLWHRRNAGQVTAPSTFKPPPRVTLTDTKKEVWLKDLANSAIPLRKLSRSIPHGVRNKVLLDQCLNKNVPIDRAVWLAKCVGTNELRTFRRLGKGNNASVLEGERKWLKDWTLVIENFIERVFFSFGEQNWKAKVNYAIQLAAHLYAEGLMDREHYLDWTVSSLESSHHSQLPMWIIIAQIYWKDLLRLRKYGRRLATALISHCHVIHAHEDRDIYVPLLSKLSHLLGTLMVATPENFVSPSVWVKYRDALKTCLPQGDEARHRSFAGINYRNEQLVASANRSQPAARIILVRNLDQVILEKPMPDEFPAQCWTVSKDKAALVRALLEWCTTPYRPGLAKVYVAHRILMHWSTLRLDVTSAVLGFMEGEALEEMECKDALYHLVSELVRSGIFLVSQYIQWLITRGGLTDPQLVMPDGPPFSRLLAELPSHILGSSQKRSRDALLRRAGFRIADDAQDADMAIRHLRHALGLPAGVTDAVSMGRPFPIKKIARRIEDASRARKAEIASWLRNTVFGGELEHSSLNAFGQHDLSTRLFNSIRTVFEAAQEFSVFADVLRMLTKCSNPEVLASIADTITRYTFVFAALSCLKNLFSILHSRLREVQEQGIGARPLLASLAYLASRVPGMDEVATQLKSDLAVSDRHNPVDACSPVSDNMVSRLSDHDGDLHEEVEKLLANGTSLDRNTMDRLFSAVIQRLQAYWAKGDEQQRVYGILLKRLRMFNPQHFDELMTQWLLYVRGLDTRATILHLYPLLVSIGCLEMPAILATASESPNAPGAGNFRHPPSAVATSQIVQTTFRTKYMQEVLQLFMAPVSSESLLTPEERYRFGILQEQAKKESPRELLCLIQLALAEYTCARAQNDLEELPLDKEANQDRLLGLLKLLVLKDPVGVAKALQIRGPDAQVDGWIDRMTTKLLVTAAGERTRVTFEQVLNLTNEFTLPFCHVKLLLSLSSNDQQQNAADSGERVPSNVELFMNAMEKSMDAQRVSWIGMLPSLSPDLTHHLKNQAQARFLNLLPSARNPPSMTLDRSMLQMRLQKAENFLAIMDTIIRGSGPMGFRQHQLVPVMVERFTDILELLQTLTPFPSQAGGLGGWGGQGASAAAAGGDSHIDLKSDILNHWLPLFLNFLTLHAQTFDTSKPGNEVRGRALMVCAGLIRELDLIHGPDFDTRQLGGRIFDLACVLVDNLAEDARLQCIQALKSPSDVKLRYIFSYQDNPHANLMLCHKERPTAMAMGTATGTGSPAPGTTPTHTPGVTPGPQNAGGAGSAVSGAGGSGNGGSYFSLPGHTQQAQAQGWHAAQQQQQQQQQSQQQQQQQQYQLQQQQQQQQQQQQGGTGPIPSPAISINTNLTHLNLGNNSNPPTPSPMNPTRPAMMMVANPWGGYSWVPTMGGPQERLTPFNFRQWEMLSEPTSQVGENDTAVNLMLFESRKVQ
Length1913
PositionKinase
OrganismNeurospora tetrasperma (strain FGSC 2509 / P0656)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Sordariomycetidae> Sordariales> Sordariaceae> Neurospora.
Aromaticity0.07
Grand average of hydropathy-0.380
Instability index48.11
Isoelectric point8.62
Molecular weight211806.19
Publications
PubMed=21750257

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP28359
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     631.01|     185|    1620|       3|     282|       1
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   35-  282 (282.84/228.79)	KGTNFGTKDdCSTRTVEL.....DLLGANLQFQIPDSIQTP.DRLLRlctsqttsflksvlnpsstettstrlqldpdrdrfpyppspptddlrNGASapppaMTSRPPlGVQQRQPQqrklsGPVLSQQRSLSQSQAQAQAQQQQPHLhtQQQQQQQQQQYDASSYlPPPPPAPTRNNN..HNN..FTNQNNTLNNAF......PPELAQQDPTSIVSPADPsGSSPALSVGVGRYG....TQRRG..GSRLRLELSHNDPSDAFSSPT
 1644- 1748 (125.92/42.20)	HGPDFDTRQ.LGGRIFDLacvlvDNLAEDARLQCIQALKSPsDVKLR..........................................................................................................................................yiFSYQDNPHANLMlchkerPTAMAMGTATGTGSPA.P.GTTPTHTPGVTP.G....PQNAGgaGS...................
 1758- 1892 (222.25/79.26)	..............................................................................................NGGS.....YFSLPG.HTQQAQAQ.....GWHAAQQQQQQQQQSQQQQQQQQYQL..QQQQQQQQQQQQGGTG.PIPSPAISINTNltHLN..LG..NNS.N.........PP.......TP..SPMNP..TRPAMMMVANPWGgyswVPTMG..GPQERLTPFNFRQWEMLSEPT
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.25|      16|      19|     460|     477|       2
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  460-  477 (23.69/20.50)	VLFHglKQRSG.LNALSIF
  481-  497 (26.56/15.43)	VLWH..RRNAGqVTAPSTF
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.23|      18|      19|     792|     809|       3
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  792-  809 (33.43/25.03)	CWTVSKDKAALV....RALLEW
  810-  831 (30.80/22.34)	CTTPYRPGLAKVyvahRILMHW
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---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.14|      16|      19|     527|     544|       4
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  527-  544 (22.83/24.10)	LSRSIPhgVRNKVLLDQC
  545-  560 (29.30/20.98)	LNKNVP..IDRAVWLAKC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.50|      19|      19|    1169|    1187|       7
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 1169- 1187 (32.89/18.85)	RLFSAVIQRLQAYWAKG.DE
 1190- 1209 (29.61/16.25)	RVYGILLKRLRMFNPQHfDE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.58|      18|      20|     415|     434|       8
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  417-  434 (35.78/25.00)	CADFFPWSGTAGNHPEDQ
  438-  455 (28.80/11.95)	TAIRVGYSEKQFVTPETQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.83|      15|      17|     891|     905|      11
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  891-  905 (28.81/16.10)	PQLVMPDGPPFSR..LL
  909-  925 (21.02/ 9.53)	PSHILGSSQKRSRdaLL
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---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.22|      17|      19|    1103|    1121|      12
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 1103- 1121 (24.51/21.65)	RVPGMDevATQLKSDLAVS
 1123- 1139 (32.71/21.89)	RHNPVD..ACSPVSDNMVS
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28359 with Med12 domain of Kingdom Fungi
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