<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28358

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMSGHDIPIQLLDGGSIDVQHHDQMNAMDTAMNLDDVDVDLFGDSVMVDTALDGLSAPRPMPSKHLRQRLDDLRTHGCHQAIAWSRQGTIASITKDGRSVEFRFLRCRPEDAGWELSEPYLYSPAIIPMHTTAGPIVHLAWSTTTPTPELAVVDAVGRITILSLTIHLNRPFITRKWDADPVDDLHAVVGCYWLPLLNPRPFGVMYGPAVWVQPEDAKAPGDGLYKYESSYTKPTGPNHPNTNKSALVSITTNGLLRLMFQNNNTRLEETAIELESITSSDDLITHAALCNDKNALLIALATASKQLRIVKATISWGNDKPAEKQAHPQNAAITASISEQHVAVAPLLQHDSNDPVLDDSMSQLSHIEFLPSVPKDKNLQAHHNPVVLTVRSHLPAEGASLYEQEPTSVIDRWEVVSEQPQTLHPAFAQLNTGNSMTNPNSMTRLRKLDSVVIPKIVVSVQVMYLGKVVCFAFSDGTIQYRDRVTMMELFNEQDVHRVLSPHDVGFQYVNDTPCLQVAFSPTNCSYVQISEDWDIKWNSMRHTLTDASTALQSAQQSAVMAALTLALSSAVTTSINFDDILALARPFSENPQFAASWVKDLVNLLKLNFDFSDEGHYDSLVRSPLFQISLSILNHMGFRGEFRPRPFEGKLSFLILQMRNFIVLVSLSLNAPKSLEISPLDESEVVEVLVGCVTWAHTLMGWMVDCLFDLADDPAFISILNEQKRFPDLANFLRARGDVSLHLLCCSSARGFITAACRRLAHLEGMSNRAIRYWEASRLKTENNDGSGGGGGKVLPDSLYFAYRKMQRATSSSLIKVQEFNEILQGFAQDVRTAYQASLSRRQSGNNQPQQQHASPQQNKNQPQQQQNAEDQFIKKAQAHCELDMLLGANPPPCFREVLLKFFTQTLPVFKSHVDPAKLYFANYEVLEIEENPRILAARKARRKYIDVFTKREIQFPISSGDARGGGGIGGGSTAAGGGGGGGGEDDGKRGGITGAGEGQTPSQSTLAPGGGISIKIELGTGSTPNIKGVSTPAGGGGSGGNAKTAGGNNAAAVGANAANGVGGGGGNINNNGTTENTSNQWRRCVRCTAVMEDFPGNHYRAGFTFVMAQQRKCACGAWWALVPKTTGEEATEGW
Length1134
PositionTail
OrganismNeurospora tetrasperma (strain FGSC 2509 / P0656)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Sordariomycetidae> Sordariales> Sordariaceae> Neurospora.
Aromaticity0.07
Grand average of hydropathy-0.270
Instability index43.93
Isoelectric point5.94
Molecular weight123719.28
Publications
PubMed=21750257

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364149
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP28358
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     104.69|      16|      96|     962|     977|       2
---------------------------------------------------------------------------
  962-  977 (33.34/13.27)	ARGG..GGIGGGSTAAGG
  980-  997 (22.96/ 7.25)	GGGGedDGKRGGITGAGE
 1034- 1047 (21.39/ 6.34)	..GG..GGSGGNAKTAGG
 1058- 1072 (27.01/ 9.60)	ANGV..GG.GGGNINNNG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     284.75|      94|     173|     179|     276|       4
---------------------------------------------------------------------------
   73-  184 (134.95/76.01)	R.THGCHqaiaWsrqgtIASITKDGRSVEF.RFLRCRPEDAGWELSEPYLY.SPAIIPmhttAGPiVHlawSTTTPTPELAV.VDAVGRITILSLTIHLNRPFITRKwDADPVDDL
  185-  282 (149.80/100.57)	HaVVGCY....W.....LPLLNPRPFGVMYgPAVWVQPEDAKAPGDGLYKYeSSYTKP....TGP.NH...PNTNKSALVSItTNGLLRLMFQNNNTRLEETAIELE.SITSSDDL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.92|      17|      43|     463|     479|       5
---------------------------------------------------------------------------
  463-  479 (32.18/19.12)	YLGKVVCF..AFSDGTIQY
  507-  525 (29.73/17.14)	YVNDTPCLqvAFSPTNCSY
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28358 with Med16 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GSTPNIKGVSTPAGGGGSGGNAKTAGGNNAAAVGANAANGVGGGGGNINNNGTTENTSN
2) SLSRRQSGNNQPQQQHASPQQNKNQPQQQQNAEDQFI
3) SSGDARGGGGIGGGSTAAGGGGGGGGEDDGKRGGITGAGEGQTPSQSTLAPGGGISI
1021
837
958
1079
873
1014










Molecular Recognition Features






MoRF SequenceStartStop




NANANA