<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28355

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMSGSSVMMNGGGASFMDVDSQPPGGSKFNDLPDEIQHITADIMPLSLLLTRLSQWTHTKLQDEIAYLASKPLPQGVLNGTTNHQSADNHDTSQESLEKKVHLLNFLQDMHSKWVKTLVITEWSKKAAQVGALIDIRELFWELIRMKQDLHWAKVPGPDLKTALEVLTTGQASWMPELGYIEPPPITWEEKEAFIDNINTMLSVRLTFDEHEKLPAAFRDYNIANGRVTFKVKGEFEVDLTIGDEDFEQQFWFIDFRFLFTPAPAELSHGVRTFLENKVNTILGDQGLAGCYNYLHEFVLTQKIIEFRRQATELAMGRWVDTLKVEKLNRAMSIQYWLKPPHGLEGPSSQTAKSWVLLGVWSGKGVEGDLDSKPSSYISLRWFRDNKEVKDFDIPLNVETISAEKLLTAVIASHVEYILTSISSKLLSKPRFAQKHARLDLEISKEEPQNSSLAVQLFDNDKAVIKIEPLTGFFTMFPRSPVFLKGQMKLNTSSNVAEEGANLMEQLRFDHTVKDLNSRVRSIGWFVCRPPITQEETKAIVYSDASGSREAFKAVWLRKANWMTRQWFVMISMSLRGDQWWLVDLSPPKPNFPAGRLRLFTKMPMTSNQLTLSDTFFRNLSVYAAGMISHITDLRKLHTLKKSHTALELPNHSLPPQVRLPTIYVRLSEMLQQRPGSSSRTLTWAKDFVSIIFKGVRSHTGDQEGPADATASQVRRDTPARIRAEARLTVIDRNKFKSLRGNVDHDVVYNHRTGQFSLKLRADMGTPVVDLLADRVQALERLMEFVEAIRLAGSNAIPQSVALREVVFTYSNDPAEPVVGPPQGPRAWNVHLDLPKDAKVVLTLEKGNPHIRALDMLQDMAQSTKTELLPSYLPFSLPLYRVLDRIEDEWESIAAKNAGNVAIVVKAAEWVTVRFTLPAPTTRRLLCLDIKTMGRKGRLLWHVKRTDEKGHERSLNAPQDEFDTLLQRSVWHAHGDGRKTFGTSAAADPKVGIETLLWSISESVKSLVGTLPPPPGTSPHPGGGTQDLQQGPQKTPQELVAAQAAQGMPPQRPKQQPPTPSQPQQQHRNVNQPQAQPQPQLHTQVQLQQAQVAQLQAQRQAQARANNSSNNNNNTFVNRAHPGQSPQQRQSGPQTQAQQQQQQRYQIQQQAQAMQRMQQQQQKQAAQQHAQQQGQGPQGQRPVHGQAGPQGVPQGQPGHGGGGGGGGMGGKNAPVVVID
Length1218
PositionTail
OrganismNeurospora tetrasperma (strain FGSC 2509 / P0656)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Sordariomycetidae> Sordariales> Sordariaceae> Neurospora.
Aromaticity0.07
Grand average of hydropathy-0.497
Instability index47.06
Isoelectric point9.11
Molecular weight136363.39
Publications
PubMed=21750257

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU365082
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP28355
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     144.79|      21|      21|    1055|    1075|       1
---------------------------------------------------------------------------
 1011- 1028 (24.82/ 8.97)	.PPPPGTSP..HPGGG.T......QDLQ
 1055- 1075 (42.62/21.79)	QPPTPSQPQQQHRNVN.Q......PQAQ
 1077- 1097 (31.03/13.45)	QPQLHTQVQLQQAQVA.Q......LQAQ
 1121- 1137 (24.22/ 8.54)	....PGQSPQQRQSGP.Q......TQAQ
 1171- 1195 (22.10/ 7.01)	QQ...GQGPQGQRPVHgQagpqgvPQGQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     286.12|     101|     123|     270|     392|       2
---------------------------------------------------------------------------
  270-  392 (144.51/117.53)	VrtflenkvNTILGDQGLAGCYNYLHEFVLTQ...KIIEFRRQATELAmgRwVDtLKVEK...LNRAMSIQYW......LK.PPhgLEGPSSQTAKSWVLLgvwsgkgvEGDLDSKPSSYIS......LRWFRDNKEVKDFD
  397-  516 (141.60/72.34)	V........ETISAEKLLTAVIASHVEYILTSissKLLSKPRFAQKHA..R.LD.LEISKeepQNSSLAVQLFdndkavIKiEP..LTGFFTMFPRSPVFL........KGQMKLNTSSNVAeeganlMEQLRFDHTVKDLN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     189.04|      47|      70|     586|     632|       3
---------------------------------------------------------------------------
  586-  632 (85.02/44.82)	PP........KPNFPAGRLRL...FTKMPMTSNQ.LTLSD.TFFRNLSVYAAGMISHITD
  654-  701 (67.05/33.97)	PP........QVRLPTIYVRLsemLQQRPGSSSRtLTWAK.DF...VSIIFKGVRSHTGD
  704-  744 (36.97/15.80)	GPadatasqvRRDTPA.RIR.........AEA.R.LTVIDrNKFKSLR....GNVDH...
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.92|      14|      16|    1138|    1151|       6
---------------------------------------------------------------------------
 1138- 1151 (27.29/14.83)	QQQQQRYQIQQQAQ
 1157- 1170 (26.62/14.28)	QQQQQKQAAQQHAQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     111.82|      31|      39|     158|     193|       7
---------------------------------------------------------------------------
  158-  188 (56.16/33.73)	DLKTALEV.LTTGQASWMPEL..GY.IEPPPITWE
  196-  230 (34.14/13.36)	NINTMLSVrLTFDEHEKLPAAfrDYnIANGRVTFK
  232-  254 (21.51/ 6.89)	..KGEFEVdLTIGDEDFEQQF..WF.ID.......
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28355 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) VKSLVGTLPPPPGTSPHPGGGTQDLQQGPQKTPQELVAAQAAQGMPPQRPKQQPPTPSQPQQQHRNVNQPQAQPQPQLHTQVQLQQAQVAQLQAQRQAQARANNSSNNNNNTFVNRAHPGQSPQQRQSGPQTQAQQQQQQRYQIQQQAQAMQRMQQQQQKQAAQQHAQQQGQGPQGQRPVHGQAGPQGVPQGQPGHGGGGGGGGMGGKNAPVVVID
1003
1218










Molecular Recognition Features






MoRF SequenceStartStop




NANANA