<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28341

Description "Related to SSN8-DNA-directed RNA polymerase II holoenzyme and SRB subcomplex subunit, cyclin C homolog"
SequenceMATDYWASSHNKKWVVDRLALFTSRAEDLRFTTPEHLAFLHIFFANLIFKIGKRLHFRQRVIATATVFFRRFYLKNHLCDTEPYIVLVACCYLAGKAEELPAHIKNVINIANTVFGELGVWPAPLDNHRLAEMEFYLVDELECDLTVFHPYRSLLALCGKETDEAGMGGPGHTGQETAPDLGVGVISGERYWGTGAGKLLLDDRTLQLAWLIINDTYRTDVCLLYPPFLIAIAAIYLSLVNHDRISKAHGSPDDPQTQDASDQLQISASTPMVTSPSLVASTPKAPTAPLGPDPITFLANLNVSMATVAAIAQEMLSFYTLSARYVDDSGNGGANAAQRQRSTDNDVQMSDGTSESTIGEKVRARQLVEVLRRMRTEKERESEGASINSVGPLMSPTATVGVQGKTGGAGRGVQEYHAVAQWRWKIEGRDETGDEDDEDEVCGICRIAYDGCCPDCKFPGDDCPLVCGKCTHVFHMHCIEKWIATPSSNRQCPMDRRVWVNAGEADPVEPEQPAQEPSMDA
Length521
PositionKinase
OrganismSerendipita indica (strain DSM 11827) (Root endophyte fungus) (Piriformospora indica)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Agaricomycetes> Sebacinales> Serendipitaceae> Serendipita.
Aromaticity0.08
Grand average of hydropathy-0.238
Instability index42.23
Isoelectric point5.16
Molecular weight57427.37
Publications
PubMed=22022265

Function

Annotated function 
GO - Cellular Component
anaphase-promoting complex	GO:0005680	IEA:InterPro
integral component of membrane	GO:0016021	IEA:UniProtKB-KW
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
cullin family protein binding	GO:0097602	IEA:InterPro
cyclin-dependent protein serine/threonine kinase regulator activity	GO:0016538	IEA:InterPro
DNA-directed 5'-3' RNA polymerase activity	GO:0003899	IEA:UniProtKB-KW
ubiquitin protein ligase activity	GO:0061630	IEA:InterPro
zinc ion binding	GO:0008270	IEA:InterPro

GO - Biological Process
anaphase-promoting complex-dependent catabolic process	GO:0031145	IEA:InterPro
cell division	GO:0051301	IEA:UniProtKB-KW
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP28341
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.49|      20|     360|      90|     144|       1
---------------------------------------------------------------------------
   61-   80 (39.28/36.10)	VIATA.TVF................FRRFYLKNHL.CD
  107-  144 (19.22/34.89)	VINIAnTVFgelgvwpapldnhrlaEMEFYLVDELeCD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     101.31|      31|      36|     238|     270|       2
---------------------------------------------------------------------------
  238-  270 (48.02/32.97)	SLVnhDRISKAHGSPDDPQTQDASDQLQISAST
  277-  307 (53.29/30.24)	SLV..ASTPKAPTAPLGPDPITFLANLNVSMAT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      77.79|      18|      24|     436|     453|       4
---------------------------------------------------------------------------
  436-  453 (37.61/25.33)	DDEDEVCGICRIAYDGCC
  461-  478 (40.19/27.58)	DDCPLVCGKCTHVFHMHC
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28341 with CycC domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) EVLRRMRTEKERESEGASINSVGPLMSPTATVGVQGKTG
2) SGNGGANAAQRQRSTDNDVQMSDGTSESTIGEKV
369
329
407
362










Molecular Recognition Features






MoRF SequenceStartStop




NANANA