<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28335

Description Uncharacterized protein
SequenceMTSRPSLAVQQQRQPTRSLSGGPPMRQSGPPPPQRTLSQSYLPHDLAGDVAPRNGASIRRGGSRLKLELSNDSFGHLASLGDSPTAAIDSSKAFTPSRIMSMADSASDIDMGALSPNNPNRVLPDGMSMLDTPSEPPNTALPMPRRRNRFPVPDPRRKSAPAPPPPLKKDARPRPWAIETPSIAPKYHQRTPDPHAPGVATRGTSTSSRAGSSTTSGAQVGHCADFFPWVGDHPEDHFSHKIITEGHYERQPGQHETSSARNYVFQALKQNRGLQGLSLVYSEVMRHRRDIGQVVAPPSFKPPPRVTLTDTKREVWLRDLANPAITLRRLSRTIPHGIRGRVLLDQCLNKKVPAERAVWLAKCVGANEIRAVKRKGANGALVMGGEAKWIRDWTICVEQFVETSVLLVASSDWSKWRADYAVRLARHLFCAELLDKDHYLEWLVTGVENSNFSKLPFWLVLSQIHWKDILRLRKHGRRLVCDILSHLQTIQAHPERELFQPLEEQLTSTVRSLMMMAPESFVLPSKWPKLRTTVQNILAHDDWPLQTVFRTIDTRNEQLTAGCVRSQPAARSVLIKVLDNALQSSIPEDLSARCLAVNKDIGAVARILLEWATSSQRPGSTKIYIAAYLLSSWASLPGFGITDTILRFLSSTAIQDSLRKEFIFHLVAELVRAELFSMERYIQWLIARGGVKNSTDVDPDGPADTRLLVELPINAISDSLKNIRASMLRRATYPVADQNREIENAIDITKRIMGWGQLAFPGKHVPNMSLQKFTKRLTRAGFQVKVQVAVWLRGAFMDTIKSHQASDQKEGFCSLSDTIFCNVRRILEACEDFRMLGEVIQALVPMTMCADILASCSDTLTMHTQVFAALRQLNPLSDCLMSRLTPIVAEETGPGVRRLLASITSLVACLPGKEDLAVKLGMDLVRYDRSSAIDACSPVSDNNPDGDLQEEGAIERLLASGSSMDKPTLERLFGTLVDTLRPNNGDESMEKFRSSISLLTKLRVFDSEYFDAQMTKWIQTRSKSPGAIQVLRLYPLMVSSGCLSLPLLVTALYGDTSVQDSAATTGARPPLFHQEIVKLLIRPLSERSSTSMSADEQYRFRIAQSLVIKKHPVAVLTAMRLAIGEFAGSPTEGRSNMPLADKILRTCIRSALMELALGDSNVVARVLLNNKQANAAQVAALLETEMDKILLPAKTGLGDVDSETALHISFEEILQLTNELTLPFCQLKLRASLAAESSSLAGGQAGDAGQRLQSQLDLFAGAMDKAIDARNMTWTGLLSCLNPEITQHLKNRAQARFLDMLPSASKEPLGLAPMELDMPAPDMKGCDEMAESLVSVVDAIVRGGSMGRPPQLVSAMADKLMDLWEILTMSPMSAAQVETRHAVQKHWLPHLLTFITLHTATFDTSKASIEVRARAVLALSGIMIELSNSLMGPVDSSATSEPNPSALIQRVFDSALVLVDSLPEDVRAGVGRVILESTSDSRLRYLMSWIPDPGADRHYLVPGVGVTTTGGGSDPRRAALISQLTAAPPESRGKPFAPRRWELLNEPTPNIGENDSSLSLTLFKAFKLQ
Length1569
PositionKinase
OrganismMagnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast fungus) (Pyricularia oryzae)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Sordariomycetidae> Magnaporthales> Pyriculariaceae> Pyricularia.
Aromaticity0.06
Grand average of hydropathy-0.191
Instability index51.58
Isoelectric point8.81
Molecular weight172607.44
Publications
PubMed=15846337

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
ECO:0000256	ARBA:ARBA00002895
ECO:0000256	ARBA:ARBA00003744
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP28335
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.01|      22|      25|      96|     120|       2
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   99-  120 (40.63/23.51)	I....MSMADSASDIDMGALS.PNNPN
  122-  148 (32.38/10.71)	VlpdgMSMLDTPSEPPNTALPmPRRRN
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     458.00|     153|     273|    1035|    1200|       3
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 1035- 1192 (232.25/157.06)	PLMVS.SGCLSLPLLVT.................ALYGDTSvQDSAATTGARPPLFHQEIVKL..........LIRPLSERSSTSMSADEQYRFrIAQSLVIKKHPVAvLTAMRLAI..GEFAGSPTEGRSNMPLADKILRTCI..RSALMELALGDSNVVARVLLNNKQANAAQVAAllETEMDKILLP
 1205- 1389 (225.74/124.45)	ALHISfEEILQLTNELTlpfcqlklraslaaessSLAGGQA.GDAGQRLQSQLDLFAGAMDKAidarnmtwtgLLSCLNPEITQHLKNRAQARF.LDMLPSASKEPLG.LAPMELDMpaPDMKGCDEMAESLVSVVDAIVRGGSmgRPPQLVSAMADKLMDLWEILTMSPMSAAQVET..RHAVQKHWLP
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     146.88|      47|      50|     392|     441|       4
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  392-  441 (70.85/70.63)	DwTICVEQFVETSVLLVASSdwSKWRADYAVRLARH...LFCAELLDKDHYLE
  445-  481 (47.81/33.65)	T.GVENSNFSKLPFWLVLSQ..IHWK.D.ILRLRKHgrrLVC...........
  659-  683 (28.21/15.24)	.........................RKEFIFHLVAE...LVRAELFSMERYIQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      82.97|      27|      51|     482|     512|       5
---------------------------------------------------------------------------
  482-  512 (42.98/31.03)	DILSHlqtiQAHPERELFQPLE...EQLTST.VRS
  536-  566 (40.00/20.61)	NILAH....DDWPLQTVFRTIDtrnEQLTAGcVRS
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     115.01|      24|     263|      23|      47|       6
---------------------------------------------------------------------------
   23-   46 (49.09/16.48)	PPMRQSGP.PPPQRTLSQS....YLPHDL
  155-  176 (32.37/10.01)	.PRRKSAPaPPPP..LKKD....ARPRPW
  297-  320 (33.56/ 8.58)	PP...SFK.PPPRVTLTDTkrevWL.RDL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     201.54|      66|     263|     685|     762|       7
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  685-  762 (95.94/81.23)	LIARGGvknstdvDPDGPADTRL...LVE.LPINAISDSLKNIRASMLRRATYPVADQnrEIENAiDITKRIMGWGQlaFPG
  957- 1026 (105.60/60.90)	LLASGS.......SMDKPTLERLfgtLVDtLRPNNGDESMEKFRSSISLLTKLRVFDS..EYFDA.QMTKWIQTRSK..SPG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.07|      25|      28|     820|     846|       8
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  820-  846 (42.26/35.04)	FCNvrRILEACED.FRMLGEVIQA...LVPM
  848-  876 (36.81/23.46)	MCA..DILASCSDtLTMHTQVFAAlrqLNPL
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28335 with Med12 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MTSRPSLAVQQQRQPTRSLSGGPPMRQSGPPPPQRTLSQSYLPHDLAGDVAPRNGASIRRGGSRLKLELSNDSFGHLASLGDSPTAAIDSSKAFTPSRIMSMADSASDIDMGALSPNNPNRVLPDGMSMLDTPSEPPNTALPMPRRRNRFPVPDPRRKSAPAPPPPLKKDARPRPWAIETPSIAPKYHQRTPDPHAPGVATRGTSTSSRAGSSTTSGA
1
218










Molecular Recognition Features






MoRF SequenceStartStop




NANANA