<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28334

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMPPPSPFSLRPWPTGDKKPKTMGEFIARANAGPGGFRSLNADDLRAQIEARKTGTTPVEPSAEMEIDAASDSDEEGDNQTMTTEALRKARDEVLKNIEIAHQSAMMTQDLVSLLMSKENPTTAKTTISPHIASLKLIGTLGADKLAAPQVNAARILDGKTMATGWKLIEVDKTVDSVMVAATRLQKEISLETAYWAEVLGVSEKGWSVCRLPYEKQTLGVRFGFSESTPEFQKKNLAPMRRKADGSVDLAAASVAQSQRVRVSIERDQTIVGRSALPSPTPPDAPLEARVLEARNTIFHQELWHEINREARTLLAHNVRLDGSTVVVEMDKSTKAVFSLVTLGENEPAASTGSDRSSEDVLAETVSSALSLLLSHAHRLNMRMRSQPGPPHLRRSRLGQPYALIKGVMAYLEYENSVGNATRFMSDLTVVLQSAGYPHASYTLTEPSITISSSSARHASSSEALLSSLTTPREFQLELTMTPKARVLISGTTILYPNLLTSYTVRLLPPSDDADAPEDEPPPSNVLRTLFPPAEFYPNFREVMLWIAGAVPRVMADEAEEFAFKLAKLTPVDSEERRDFVKSISGIAVHGTQPDQSDVKFEIRLSGIDLKSGGGRESDAEKRLSGQYTPELHVFGKWSAPSGNGDVLQHEWIWSVDRKESMSLEEVYQGLLRGDLVL
Length677
PositionHead
OrganismMagnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast fungus) (Pyricularia oryzae)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Sordariomycetidae> Magnaporthales> Pyriculariaceae> Pyricularia.
Aromaticity0.06
Grand average of hydropathy-0.345
Instability index47.77
Isoelectric point5.58
Molecular weight74197.15
Publications
PubMed=15846337

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364140
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP28334
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.82|      17|      39|     482|     498|       1
---------------------------------------------------------------------------
  482-  498 (29.77/15.84)	PKARVL..ISGTTILYPNL
  521-  539 (29.05/15.30)	PPSNVLrtLFPPAEFYPNF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     106.18|      34|     103|      39|      72|       2
---------------------------------------------------------------------------
   39-   72 (57.54/38.37)	LNADDLRA.QIEARK..TGTTPVEPSAEMEIDAASDS
  140-  176 (48.64/31.27)	LGADKLAApQVNAARilDGKTMATGWKLIEVDKTVDS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     101.22|      32|      39|     540|     572|       5
---------------------------------------------------------------------------
  540-  572 (48.66/34.93)	REVMLWIAGAVPRVMADEAEEFAFKLaKLTPVD
  577-  608 (52.56/33.39)	RDFVKSISGIAVHGTQPDQSDVKFEI.RLSGID
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28334 with Med17 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MPPPSPFSLRPWPTGDKKPKTMGEFIARANAGPGGFRSLNADDLRAQIEARKTGTTPVEPSAEMEIDAASDSDEEGDNQTMTTEALRK
1
88










Molecular Recognition Features






MoRF SequenceStartStop




1) FRSLNAD
2) SPFSLRPWPTGDKKPKTMGEFIARANA
36
5
42
31