Description | Mediator of RNA polymerase II transcription subunit 6 |
Sequence | MAAKPDTSLPDEIQWNSMEHVMQFGGIHDNTILYYFAASPFFDPTSNNAVVFSQAVRNQSQLHIIATRQAFEARLREMSGLEYIVAQEPAETGPGMGTGVWVIRKQTRRKVKGSNGFPAPDEIEVHSDYFVVGENIYMAPSLANILSSRIASIASSITKTFPIADSIKKWSPALGHGYKTPATNSLTSRPRGTGLESKEATPMPESQTSSAMTAAKNADRSDPDEKLAEESFAIHTHYGTEYMDENPITGKPGDFHFSSTGRKERLNVPGQQQGKAIGSGPDTTLPVLKTLPDNSPLSKDAKSEKTGKTGGPPKPKRRKSKGGPNTPS |
Length | 328 |
Position | Head |
Organism | Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast fungus) (Pyricularia oryzae) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Sordariomycetidae> Magnaporthales> Pyriculariaceae> Pyricularia. |
Aromaticity | 0.07 |
Grand average of hydropathy | -0.647 |
Instability index | 50.36 |
Isoelectric point | 8.84 |
Molecular weight | 35548.43 |
Publications | PubMed=15846337 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364143 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP28333 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 48.42| 14| 18| 175| 188| 1 --------------------------------------------------------------------------- 175- 188 (26.77/15.82) GHGYK..TPATNSLTS 194- 209 (21.65/11.47) GLESKeaTPMPESQTS --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 102.80| 31| 42| 252| 283| 2 --------------------------------------------------------------------------- 252- 283 (52.46/34.03) PGDFHFSSTGRKERL....NVPGQQQGKAIGsGPDT 292- 326 (50.34/28.29) PDNSPLSKDAKSEKTgktgGPPKPKRRKSKG.GPNT --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 39.27| 10| 18| 111| 120| 3 --------------------------------------------------------------------------- 111- 120 (19.90/11.15) VKGSNGFPAP 131- 140 (19.36/10.67) VVGENIYMAP --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 104.32| 33| 210| 2| 40| 4 --------------------------------------------------------------------------- 2- 40 (47.82/62.33) AAK.PDTSLPDEiqwNSMEHvmQFgGIHDNTILYYFAASP 214- 247 (56.49/44.69) AAKnADRSDPDE...KLAEE..SF.AIHTHYGTEYMDENP --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 48.17| 14| 18| 52| 69| 5 --------------------------------------------------------------------------- 52- 65 (24.06/23.77) FSQAVRNQSQLHII 71- 84 (24.11/11.67) FEARLREMSGLEYI --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) GPPKPKRRKSKGG 2) LSKDAKSE | 311 297 | 323 304 |
© 2021 Shailesh Lab
Designed by Dr. Shailesh Lab & Dr. Jitendra K. Thakur Lab