<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28331

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDPGDYDTNTLLINDIASIAFRVYEPVFSSSAYTFAASDVERDLRKDGYLVYADGIRRGIWCFYLVGREGSNVPQTGPQSLGASLEVCGYKLNRVDEGGFEPIGLLKTRHATTGALNPRSSASPAGSIIEQQSSRSAQSPGSLSQQTWNTGPQDQEAKPDARGYSSVPVREIYGYFIKATLSSLSTAFCSVIGAIALNSRTFLLPPKAFASAEGTVGPHITKANLATIRVYLTTTGSLVMSLTISCVDGLMASADRIAANPMDSKVPVLVAPLGAFGTLQGVVDGAVGIAHCSPQSPEAQITSLRRDMDGSVGRYREDCLQLLRLRGIPLSVLEETSWVIIHSLRKRVSKQASDGKATPGGVHGVGSLCWPSVLCFHKAPRVCQQPGAPHTGVSGGFNEKSLDPLSFASSWLIGSEKRDSMLLKRQKEREAAVVASRQAGDKEGLAQTLSTYSPLALRRQSNSNAPPVPGAMYPTPPDGVQNPAAVAQYLEAAVSSPANNTSVAAVAPNDVDTVMTQAGGMGEAFTEGWDNADKRADTGYLEISGAMGSDIFGDNSITDADFNFFDDQPGGDMDFSNAAGDTSGTLDLTAPKLPSFEGVPQNSSTKPLIPTAIPPPVPVFAKPELRHARSSMMGNIRQANGETRARKQAAAGIKRVPSPFNANIVYKRVRASLSLQNLPKSPATAMSPMRRGSIYEKLGFDSSLAVNNSKYQENGKFGYRWDSKPPEKDAAHVSAPTTTSYFQRHGKKRAKLKEAPEQVGALVAKITGDLEASSLHQSPTKIDDQPSDDDLSLVSDVDDSSYTSDEPSSPTKSVATRRRLEDDANSMALSLRDLENMGAPSPQLPVDLSRFANEPLELPLAKYFAERQSVELQGSLTDEDFINTAQILTEQAASGLLRLTAPPLDSDFANSKETRRNLALYNRHCLQVLCSALPLSLRGVNESRFRGLVDLQDFPILGPPPRQQARPPGSVEQIRPSVFQIQPPQFELRRHETRLSLLPSCMDFWESLGLGPSQGPKDVHAVCVFPEKGGMSDHVDTFLNRMRNVYESLKLGTFERLPSNSSISEGLLSFEAEGSSVSVVESPGSLMPPQTTPVADQMGKLSQALAGAAVDRKNFVVYFIYNPTNPSSIVDCCAAFQRLYELFKRILTDKRLSVANELVMQLIPLDLVAAPSALAIPAPSEYVRLSLETYDRCTVCDGSMPMPAVILEQSLPRMIDFKLTGTSSTNVLHENSCMHVAYAQSVDERWITAAWTDNRGLKQMTASYCLGRRERPLTTSFANVAQEIWETTQEVISAWKVHWQIIISKCGPMEPHEIEVWTSLQQGEAKEPSTSLTLLAVDTDPSLHLIPPAVKIPLSAPTAFYTTPASTPQASVMSPDGNAPATPMGATGGTAVPTTPGAETTPAESDPDTILLDITDTTWGAVLSHRLNNAASVVELNPTLVSGYLVKRGGTRVEDPPVVMEVNVMYTEGNPRMYEALLREMLTYFRGLGSLARARGMVDRDTDIRPWHVAAAEKGVQVLYQLM
Length1523
PositionKinase
OrganismMagnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast fungus) (Pyricularia oryzae)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Sordariomycetidae> Magnaporthales> Pyriculariaceae> Pyricularia.
Aromaticity0.07
Grand average of hydropathy-0.262
Instability index48.06
Isoelectric point5.60
Molecular weight164508.09
Publications
PubMed=15846337

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
ECO:0000256	RuleBase:RU364134
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP28331
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     176.91|      51|      51|     771|     821|       1
---------------------------------------------------------------------------
  566-  594 (25.97/ 7.46)	............DDQ..PG.GDMDFSNAAGDTSGTLDltAP.KLP............
  771-  821 (88.08/40.48)	EASSLHQSPTKIDDQ..PSDDDLSLVSDVDDSSYTSD..EP.SSP.TKSVATRRRLE
  823-  871 (62.86/27.07)	DANSMALSLRDLENMgaPSPQ.LP....VDLSRF.AN..EPlELPlAKYFAERQSVE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      92.80|      26|      73|      75|     100|       2
---------------------------------------------------------------------------
   75-  100 (47.88/29.70)	QTGPQSLGASLEVCGYKLNRVDE.GGF
  149-  175 (44.91/27.36)	NTGPQDQEAKPDARGYSSVPVREiYGY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     423.34|     162|     311|     873|    1089|       3
---------------------------------------------------------------------------
  873-  955 (73.20/38.93)	.................................................................................................................QGSLTDEDFINTAQI..LTEQAASGLL......RLTAPPLDSDfANSKETRRNLALYnrhclQVLCSALPLSLRGVNE.SRFRGLVDlQDFP
  999- 1089 (113.28/109.03)	PSCMDFWESLGLGPSQGPK...DVHAVCVFPEKGGMSDHVDTFLNRMRNVYEslklgTFERLPSNSSIS.EGLLSFEAEGSS..VSVVESPGSLMPP............................................................................................................
 1311- 1503 (236.86/113.31)	PHEIEVWTSLQQGEAKEPStslTLLAVDTDPSLHLIPPAVKIPLSAPTAFYT.....TPASTPQASVMSpDGNAPATPMGATggTAVPTTPGAETTPaesdpdtillditdttWGAVLSHRLNNAASVveLNPTLVSGYLvkrggtRVEDPPVVME.VNVMYTEGNPRMY.....EALLREMLTYFRGLGSlARARGMVD.RDTD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.21|      17|      24|     272|     288|       4
---------------------------------------------------------------------------
  272-  288 (29.99/20.36)	PLGAFGTLQGVVDGAVG
  297-  313 (30.22/20.58)	PEAQITSLRRDMDGSVG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     190.36|      60|     343|     314|     391|       5
---------------------------------------------------------------------------
  314-  380 (89.42/66.09)	RYREDCLQLLRLrgIPLSVLEETSWVII..HSLRKRVSKQASDgKATpggVHGvGSLCWPSVLCFHKAP
  396-  413 (13.85/11.47)	GFNEKSLDPLSF.........ASSWLI..........................................
 1156- 1212 (87.08/45.46)	..NELVMQL.....IPLDLVAAPSALAIpaPSEYVRLSLETYD.RCT...VCD.GSMPMPAVILEQSLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.92|      20|      28|     658|     680|       8
---------------------------------------------------------------------------
  670-  696 (22.98/19.28)	RASLSLQNlPKspatamSPMRRGSIYE
  701-  720 (32.94/16.42)	DSSLAVNN.SK......YQENGKFGYR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     118.61|      23|      24|     519|     541|       9
---------------------------------------------------------------------------
  470-  490 (38.32/22.36)	GAMYPTPPDGVQNPAAVAQ..YL
  519-  541 (42.53/25.71)	GGMGEAFTEGWDNADKRADTGYL
  545-  565 (37.77/21.92)	GAMGSDIF.G.DNSITDADFNFF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.35|      13|     841|     118|     131|      10
---------------------------------------------------------------------------
  118-  131 (20.53/14.74)	PRSSASPAGSiIEQ
  961-  973 (26.81/14.96)	PRQQARPPGS.VEQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28331 with Med13 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ANNTSVAAVAPNDVDTVMTQAGGMGEAFTEGWDNADKRADTGY
2) ASSLHQSPTKIDDQPSDDDLSLVSDVDDSSYTSDEPSSPTKSVATRRRLED
3) GKFGYRWDSKPPEKDAAHVSAPTTTSYFQRHGKKRAKLKEAPEQ
4) LALRRQSNSNAPPVPGAMYPTPPDGVQNPAAVAQYLEA
5) LDLTAPKLPSFEGVPQNSSTKPLIPTAIPPPV
6) TPASTPQASVMSPDGNAPATPMGATGGTAVPTTPGAETTPAESDPDTIL
498
772
715
455
586
1363
540
822
758
492
617
1411










Molecular Recognition Features






MoRF SequenceStartStop




1) KFGYRW
716
721