<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28324

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMAESQGVGEEPRTGEGTESLRNWQDFIERCLITRLDNETFERFAPIHHAKYPLSPRVLAELFLRPQKNNHDVLDPRIPQYMQILLAHHYIDALSILLAMYKYSTSHKQIQDVTGAGENDQSGEQQQQPLRWGNSYATEEHIFYRLTRSVSHGTGIHDSWDALRIARIMAKWMELFTATAGAFAADMVNQQMQTAEERDRVERERRKQLPRVDEMESARAGFVMLLLGVCESKPVLGALGKPYAKTARKELSDALGNFVPTIMQSAEQISQRLVQFRTETLAGFEPVDKAKAAANADMDDFLDSTMGLDSLVVPEIPISNTRAGLYIYLNSLLVGRPLMDDAAIFNYLHNRYQGDLQQTAVDLILVSFDVVANAASVIQSPKAAHVLRSYLTNKVPLLLASLAASGSGLYPFNAAACVEHATRQVSSATFPNMSDYISSRSGNTLTEGTREDFLFACCLHGLIPETQIEPILNETCYNSLPTEGRLVKEALVQECLADPERTVQLVKDIEKCNGNVGAICVALTEVLGQLCTMRETMTLKTLCGQLARDPMYLDVLLLFNKLSAIVYPLCDLLDNWKHDEDQGEAQPFYEEFGSMLLLLLALVNRYNLTAADMGARSPDSFVAKLIGKGRLFRPLDELSPEENGHLDKWIHGLFDSDAGGLGDELMSSCPPQEFYLLIPTLFYNIVLAVSTGSLSEDSLRCGVEYLVDTFLLPSLVPAVTYLSNHLWLDNHPPEQKAILKILQLILQPSSISSEASSVLSSVLSIVAKPLDQALRAYQRRDPRNQEIEPLLRILKEHVPLSRRTGAAENSELEAWSSTPNGGLSQAVRSTIRGFIAWGLQPAGTESTPTAYTHRQLLAATRILGAKQTVRLILDELKEQVQAGNQSVAYDVCCAIICAPNVATDDVDPSSQVNLLDATAQAHGPQQRPMSLRQALRAAAEDWKRIHKDDPVAFEIVVRLHRRVEAQLAVSVSAAAAAAAEAVLQGDGGNMLDDAMAAAGVVDGDAAAAMALDAATVGLDMGGGGAGDLGLGGSTANSVGGLDLNDQDVFGGLGPLNGWDDMDLA
Length1063
PositionTail
OrganismMagnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast fungus) (Pyricularia oryzae)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Sordariomycetidae> Magnaporthales> Pyriculariaceae> Pyricularia.
Aromaticity0.06
Grand average of hydropathy-0.106
Instability index48.73
Isoelectric point4.94
Molecular weight116123.61
Publications
PubMed=15846337

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP28324
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      71.10|      17|      17|     448|     464|       1
---------------------------------------------------------------------------
  434-  449 (19.68/10.06)	.DYISSRSGNTLTEGTR
  450-  466 (30.54/19.64)	EDFLFACCLHGLIPETQ
  468-  482 (20.87/11.11)	EPILNETCYNSLPTE..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.28|      15|      17|     981|     997|       2
---------------------------------------------------------------------------
  981-  997 (21.74/20.58)	VLQGDGGNMLddAMAAA
  999- 1013 (24.54/14.87)	VVDGDAAAAM..ALDAA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.09|      16|      18|     730|     747|       3
---------------------------------------------------------------------------
  732-  747 (25.79/22.04)	PEQKAIL.KILQLILQP
  752-  768 (19.30/ 6.38)	SEASSVLsSVLSIVAKP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.31|      15|      15|     697|     711|       5
---------------------------------------------------------------------------
  697-  711 (26.70/16.34)	SLRCGVEYLVDTFLL
  713-  727 (27.62/17.15)	SLVPAVTYLSNHLWL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     117.94|      29|     687|     113|     141|       6
---------------------------------------------------------------------------
    6-   23 (18.76/ 7.09)	.GVGEEPRTGEGTESLRNW..........
  113-  141 (53.99/34.54)	TGAGENDQSGEQQQQPLRWGNSYATEEHI
  803-  830 (45.19/27.69)	TGAAENSELEAWSSTP.NGGLSQAVRSTI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     216.62|      72|     683|     206|     284|       7
---------------------------------------------------------------------------
  206-  284 (102.31/92.39)	KQLPR..VDEM.ESARAGFVMLLLGVCESkpVLGAlgkPYAKTARKELSDALgNFVPTIMQsAEQISQRLVQFRTETLAGFE
  865-  939 (114.31/77.31)	KQTVRliLDELkEQVQAGNQSVAYDVCCA..IICA...PNVATDDVDPSSQV.NLLDATAQ.AHGPQQRPMSLRQALRAAAE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      49.70|      11|      19|     484|     494|       8
---------------------------------------------------------------------------
  484-  494 (18.48/10.56)	RLVKEALVQEC
  503-  511 (14.62/ 6.97)	QLVKD..IEKC
  520-  530 (16.61/ 8.82)	VALTEVLGQLC
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28324 with Med5 domain of Kingdom Fungi
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