<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28309

Description Uncharacterized protein
SequenceMIPHSSAGVQPWGRSLRALNNGSGRVDASQALVQSDPQLEKLSMSMPQPLPRQPAVIDLTANASDSQDREPPAKRLKLDAPPGSCPPEGSPAPGSGGEARSTPGTASSKPNPLAWRGRPVWSFQALISETTGAVEAKEDDTTSQGKNPASPPPLPLVPWKHTPQEASRSNSAKANVASTKEVQTTPYRIVVPPVAPKLKGERVADFSPWTGNHPEDTLNDHTAKQGHYDRTQVSQNESNTARPSLYAQLKHRSGLQMLSSVFAAALEKRQSHSTIATPSSFKPPPRVTLTDNKREAWLRDLANPSVPLRRLSRTIPHGIRGKVLLDQCLGKGIPVPRAIWLARCVGANEIRAFKRKGTSGTLALGLETKWVRDWTSTVQQFLESVIGTCGSSDWKTKMTYAVSLTSRLFFERLLDHDQYLSWFLASLEAAPLNTVPVWLLMLGIYWNNIMRYRKHKATLVAKLLEWAATPFRHGSRRVRVNMDNVYHIIAELVRSQTFSVGRYLQWLMAKGVANDPLPDQHKAISDDLRLLIQLPLARLPEYVRNLRNTLLSRAGITASDEESTIATVKASIAQRLPKIFGPQASDAMLTDQPLSSLTWAVKSEIGLWIRRGVSGHCREPVRYAVFSPFKYFYNIRDVLESFGDISMLADVLKQATNCDDSVVLASVADTINFHVDSLSIIGAATDLFKGLVESYARLKRLGAPSLDLIFSLIELGLRMPSEFNTVALLRQDLSRIENKSALAAPSPLSDNLSTAFNDADSSFQEKLDQILFSGGGMDESTMDSIFNSLTAALANENGHLKLSANDICRYLAYLRSFHPKRFDARLVRWVCGVLKSPSRIAMVRILPPLIGVGCVTIHAFVMLVKKLLQSERVASVVPKVTDLQLDLLELLVSQESSGSRYTDMVTYRYYLAQQEFIDKHPEECLNIIRAAVPLINMRQTESASESNLADLTKCAMVLLQTLLTQKPERMVQCCTQKLVGQDPASTMILQKALDALLGFNSQGLFATMSEAERVIGMNNDFSLPICQLKLQLLFNAEAGNGVDNGIVDVMFKAAMADARSKRSHWYGLVSLMNQDAVRQIRERAEKGFFSIPILEEPIGDPTVADKSNSIETARLYLAIIEKLAYSIPETGVPSVAPMLVEKMELLLQKFITMQPNPSAPAESCQIAQARSNFERSLAFWFSALLRLVVLHRSAFNTSALTPKPIGLQEQARMLISIFCITLARLPDRVIRLYPSANYFPHPVQSEGYRPCPGILLQTHALDVAAALIDTFPDEARQQCARFLKEKCPPFLQFQNDSRFLYLLGPVMDTSTLNSSQPASLPSPAAGGSTPTPTGNLAGGPPNSQQNLSSASGLPAGLSEGVNCIASHLRLQYRGRVLGAYPVRPWELLEDAAPIVGMNDTAVSLKYFDARRVRA
Length1414
PositionKinase
OrganismAspergillus niger (strain ATCC 1015 / CBS 113.46 / FGSC A1144 / LSHB Ac4 / NCTC 3858a / NRRL 328 / USDA 3528.7)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus> Aspergillus subgen. Circumdati.
Aromaticity0.07
Grand average of hydropathy-0.161
Instability index47.95
Isoelectric point9.06
Molecular weight155697.04
Publications
PubMed=21543515

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
ECO:0000256	ARBA:ARBA00002895
ECO:0000256	ARBA:ARBA00003744
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats
>MDP28309
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.31|      12|      30|      61|      72|       1
---------------------------------------------------------------------------
   61-   72 (21.94/11.64)	ANASDSQDREPP
   92-  103 (21.37/11.13)	APGSGGEARSTP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.48|      23|      67|    1003|    1025|       2
---------------------------------------------------------------------------
 1003- 1025 (41.73/31.10)	GLFATMS.EAERVIGMNND...FSLPI
 1067- 1093 (30.75/20.79)	GLVSLMNqDAVRQIRERAEkgfFSIPI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     120.65|      41|      68|     854|     895|       5
---------------------------------------------------------------------------
  854-  895 (61.47/41.12)	CVT.IHAFVMLVkKLLQSERVA.SVVPKVTDLQLDLLELLVSQE
  924-  966 (59.18/35.24)	CLNiIRAAVPLI.NMRQTESASeSNLADLTKCAMVLLQTLLTQK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     269.41|      89|     455|     269|     371|       8
---------------------------------------------------------------------------
  269-  371 (127.97/123.00)	RQSHSTIATPSSFKPPPrvTLTDNKREAwLRDlANPSVPlRRLSRTIPHGirGKvlLDQCLGKGIPVPRAIWLARCVG.....ANEI.......RAFKRKGTSGTLalgleTKWV
  730-  830 (141.44/91.10)	RQDLSRIENKSALAAPS..PLSDNLSTA.FND.ADSSFQ.EKLDQILFSG..GG..MDESTMDSIFNSLTAALANENGhlklsANDIcrylaylRSFHPKRFDARL.....VRWV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     126.59|      42|      67|    1113|    1157|       9
---------------------------------------------------------------------------
 1113- 1157 (66.30/43.87)	ARLYLAIIEKLAYSipeTGVPSVAPM.LVEKMELLLQKF.ITMQPNP
 1183- 1226 (60.29/32.67)	ALLRLVVLHRSAFN...TSALTPKPIgLQEQARMLISIFcITLARLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      64.23|      20|     316|     156|     176|      10
---------------------------------------------------------------------------
  109-  131 (27.52/14.23)	KPNP....................L.A.WRGRPVwsfQALISETT
  132-  172 (16.39/ 9.73)	GAVEakeddttsqgknpasppplpLvP.WKHTPQ...EASRSNSA
  224-  241 (20.32/ 8.42)	KQG........................hYDRTQV...SQNESNTA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28309 with Med12 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GERVADFSPWTGNHPEDTLNDHTAKQGHYDRTQVSQNESNTARPSLYAQL
2) LNSSQPASLPSPAAGGSTPTPTGNLAGGPPNSQQNLSSAS
3) MIPHSSAGVQPWGRSLRALNNGSGRVDASQALVQSDPQLEKLSMSMPQPLPRQPAVIDLTANASDSQDREPPAKRLKLDAPPGSCPPEGSPAPGSGGEARSTPGTASSKPNPLAWRGRPVWS
4) QALISETTGAVEAKEDDTTSQGKNPASPPPLPLVPWKHTPQEASRSNSAKANVASTKEVQTTPYRIVVPPVAPK
200
1312
1
124
249
1351
122
197










Molecular Recognition Features






MoRF SequenceStartStop




1) PAKRLKLD
72
79