<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28306

Description Mediator of RNA polymerase II transcription subunit 8
SequenceMSSLNQDQIKTLEQSRQRLIQLTHSLASLITSLNQSDPLPSWTSLQSQATIISNNLLTISDHLSDNRDLLSNIVAYPDASYPSRVPANNVALEQVLRTKLDPRVEDWVARGRRAGAPTTSSDAGAGALGQYQTSSGQRLLSDDAIAELWDWAPVAANEEARKRNWGGNYTLEEREMGIENVVTGLSRVLEDDDEEDESDSEEGEGEADEMEVVGARRRSGAGAGLEFDIAAANTGSGANAGAGAKVVAPVVPLDEILRFMTTGAVPGQR
Length269
PositionHead
OrganismAspergillus niger (strain ATCC 1015 / CBS 113.46 / FGSC A1144 / LSHB Ac4 / NCTC 3858a / NRRL 328 / USDA 3528.7)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus> Aspergillus subgen. Circumdati.
Aromaticity0.04
Grand average of hydropathy-0.461
Instability index49.41
Isoelectric point4.44
Molecular weight28873.35
Publications
PubMed=21543515

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP28306
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.89|      14|     114|     114|     127|       1
---------------------------------------------------------------------------
  114-  127 (27.12/15.14)	AGAPTTS.SDAGAGA
  230-  244 (21.77/10.85)	AAANTGSgANAGAGA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      34.48|      10|      15|     203|     212|       3
---------------------------------------------------------------------------
  203-  212 (17.26/10.65)	GEGEADEMEV
  220-  229 (17.22/10.61)	GAGAGLEFDI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28306 with Med8 domain of Kingdom Fungi
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