Description | Mediator of RNA polymerase II transcription subunit 11 |
Sequence | MTDVKDTRKPDQVFTSADRIRQLNEIDKDVAKLIHSAGLAIQALTNARSGESPSDNSLASHQARFKEATSQYFALLSSIDVRLRRQVYALEEASILAPETASRAENLPGASSGGVAGASSNPLDVSWLNSRKDTVGKDKEAELWAAAREFVERISNPASVSSGAKTESEQEKMEVD |
Length | 176 |
Position | Head |
Organism | Aspergillus niger (strain ATCC 1015 / CBS 113.46 / FGSC A1144 / LSHB Ac4 / NCTC 3858a / NRRL 328 / USDA 3528.7) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus> Aspergillus subgen. Circumdati. |
Aromaticity | 0.05 |
Grand average of hydropathy | -0.540 |
Instability index | 38.21 |
Isoelectric point | 5.19 |
Molecular weight | 19034.81 |
Publications | PubMed=21543515 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364147 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP28300 No repeats found No repeats found |
MoRF Sequence | Start | Stop |
1) EKMEV 2) KDKEAELWAAAREFVERISNPASVS 3) NSRKDTV | 171 137 129 | 175 161 135 |
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