<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28297

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAPVQLENHQLVPPGGSGSGGPASAPAPPPPGAAVAAAAAAAASPGYRLSTLIEFLLHRAYSELMVLTDLLPRKSDVERKIEIVQFASRTRQLFVRLLALVKWANNAGKVEKCAMISSFLDQQAILFVDTADRLASLARDALVHARLPSFAIPYAIDVLTTGSYPRLPTCIRDKIIPPDPITKIEKQATLHQLNQILRHRLVTTDLPPQLANLTVANGRVKFRVEGEFEATLTVMGDDPDVPWRLLKLEILVEDKETGDGRALVHSMQINFIHQLVQSRLFADEKPLQDMYNCLHSFCLSLQLEVLHSQTLMLIRERWGDLVQVERYHAGKCLSLSVWNQQVLGRKTGTASVHKVTIKIDENDASKPLQIFHDPPLPASDSKLVERAMKIDHLSIEKLLIDSVHARAHQKLQELKAILRGVNANENSSIETALPALVVPILEPCGNSECLHIFVDLHSGMFQLMLYGLDQATLDDMEKSVNDDMKRIIPWIQQLKFWLGQQRCKQSIKHLPTITSETLQLSNYSTHPIGNLSKNKLFVRLTRLPQYYIVVEMLEVPNKPTQLSYKYYFLSVNAVDRDDSPLMALLLQQFKENLQESVYRTKNGKQPRTSTKRKLSDDLCPVEPKKTKRSGEMRAFNKVLAHFVAMCDTNMPFVGLRLELSNLEIPHQGVQMEGDGFSHAIRLLKIPPCKGINEETQKALDRSLLDCTFRLQGRNNRTWVAELVFANCPLNGTSTREQGPSRHVYLTYENLLSEPVGGRKVVEMFLNDWNSIARLYECVLEFARSLPDIPSHLNIFSEVRVYNYRKLILCYGTTKGSSISIQWNSIHQKFHISLGTVGPNSGCSNCHNTILHQLQEMFNKTPNVVQLLQVLFDTQAPLNAINKLPTVPMLGLTQRTNTAYQCFSILPQSSTHIRLAFRNMYCIDIYCRSRGVVAIRDGAYSLFDNSKLVEGFYPAPGLKTFLNMFVDSNQDARRRSVNEDDNPPSPIGGDMMDSLISQLQPPPQQQPFPKQPGSSGAYPLTSPPTSYHSTVNQSPSMMHTQSPGNLHAASSPSGALRAPSPASFVPTPPPSSHGISIGPGASFASPHGTLDPSSPYTMVSPSGRAGNWPGSPQVSGPSPATRMPGMSPANPSLHSPVPDASHSPRAGTSSQTMPTNMPPPRKLPQRSWAASIPTILTHSALNILLLPSPTPGLVPGLAGSYLCSPLERFLGSVIMRRHLQRIIQQETLQLINSNEPGVIMFKTDALKCRVALSPKTNQTLQLKVTPENAGQWKPDELQVLEKFFETRVAGPPFKANTLIAFTKLLGAPTHILRDCVHIMKLELFPDQATQLKWNVQFCLTIPPSAPPIAPPGTPAVVLKSKMLFFLQLTQKTSVPPQEPVSIIVPIIYDMASGTTQQADIPRQQNSSVAAPMMVSNILKRFAEMNPPRQGECTIFAAVRDLMANLTLPPGGRP
Length1452
PositionTail
OrganismBos taurus (Bovine)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Artiodactyla> Ruminantia> Pecora> Bovidae> Bovinae> Bos.
Aromaticity0.06
Grand average of hydropathy-0.201
Instability index51.58
Isoelectric point9.02
Molecular weight160699.72
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
core mediator complex	GO:0070847	IBA:GO_Central
mediator complex	GO:0016592	IBA:GO_Central

GO - Biological Function
transcription coactivator activity	GO:0003713	IEA:Ensembl
transcription coregulator activity	GO:0003712	IBA:GO_Central

GO - Biological Process
positive regulation of transcription initiation from RNA polymerase II promoter	GO:0060261	IEA:Ensembl
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central
stem cell population maintenance	GO:0019827	IEA:Ensembl









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP28297
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     204.04|      32|      32|    1099|    1130|       1
---------------------------------------------------------------------------
   14-   45 (24.57/ 6.39)	.........PGG.SGSGGPasAPAPPPP.GAAVAaaaaaaaS..P
 1033- 1062 (40.84/16.11)	SPSMMHTQSPGNlHAASSP..SGALRAP...SPA.......S...
 1099- 1130 (65.81/31.04)	SPSGRAGNWPGS.PQVSGP..SPATRMP.GMSPA.......N..P
 1134- 1163 (37.50/14.12)	SPVPDASH...S.PR.AGT..SSQT.MPtNMPPP.......RklP
 1185- 1210 (35.31/12.81)	LPSPTPGLVPGL.AGSYLC..SPLERFL.G...............
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      94.64|      30|      32|     244|     273|       3
---------------------------------------------------------------------------
  244-  273 (48.89/30.91)	RLLKLEILVEDKETGDGRALVH....SMQINFIH
  274-  307 (45.75/28.47)	QLVQSRLFADEKPLQDMYNCLHsfclSLQLEVLH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.06|      24|      24|    1361|    1384|       4
---------------------------------------------------------------------------
 1360- 1383 (39.65/22.24)	KMLFFL..QLTQKTSVPPQEPVSIIV
 1384- 1409 (34.41/18.19)	PIIYDMasGTTQQADIPRQQNSSVAA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.13|      25|      32|     509|     537|       5
---------------------------------------------------------------------------
  509-  537 (38.09/33.15)	HLPT..ITSETLQLSNYSTHpignLSKNKLF
  542-  568 (41.04/24.42)	RLPQyyIVVEMLEVPNKPTQ....LSYKYYF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     104.27|      32|      32|      64|      95|       7
---------------------------------------------------------------------------
   64-   95 (51.36/41.99)	LMVLTDLLPRKSDVERKIEIVQFASRTRQLFV
   97-  128 (52.92/43.53)	LLALVKWANNAGKVEKCAMISSFLDQQAILFV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.60|      14|      37|    1245|    1259|       9
---------------------------------------------------------------------------
 1245- 1259 (21.47/16.52)	LKCRVALSP.KTNqTL
 1283- 1297 (22.14/11.66)	FETRVAGPPfKAN.TL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     379.21|     125|     508|     327|     455|      12
---------------------------------------------------------------------------
  327-  455 (206.09/143.90)	YHAGKCLSLSV.WN...QQ......VLGRKTGTASVHKVTI.KIDENDASKP.....LQIFHD...........PPLPASDskLVERA.MKIDHLSIekLLIDSVHAR.AHQKLQ..ELKAILRGVNANENSSIETALPALVVPILEPC.GNSECLHIFVD
  810-  966 (173.13/110.31)	YGTTKGSSISIqWNsihQKfhislgTVGPNSGCSNCHNTILhQLQEMFNKTPnvvqlLQVLFDtqaplnainklPTVPMLG..LTQRTnTAYQCFSI..LPQSSTHIRlAFRNMYciDIYCRSRGVVAIRDGAYSLFDNSKLVEGFYPApGLKTFLNMFVD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.05|      25|     402|     570|     594|      13
---------------------------------------------------------------------------
  570-  594 (41.88/29.86)	SVNAVDRDDSPLMALLLQQFKENLQ
  975-  999 (45.17/32.94)	SVNEDDNPPSPIGGDMMDSLISQLQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.45|      13|      25|     599|     611|      14
---------------------------------------------------------------------------
  599-  611 (22.36/12.67)	RTKNGKQPRTSTK
  625-  637 (22.08/12.43)	KTKRSGEMRAFNK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.21|      14|      27|     166|     179|      16
---------------------------------------------------------------------------
  166-  179 (26.56/14.57)	RLPTCIRDKII....PPD
  192-  209 (19.65/ 8.92)	QLNQILRHRLVttdlPPQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.63|      16|     270|    1063|    1079|      17
---------------------------------------------------------------------------
 1063- 1079 (29.98/20.53)	FVPTPPPSSHGISiGPG
 1336- 1351 (34.65/19.39)	FCLTIPPSAPPIA.PPG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28297 with Med14 domain of Kingdom Metazoa
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