<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28289

Description Uncharacterized protein
SequenceMTCAYYSAISEAKIKKRQATDPNMEWTQISTRYLREQLAKIADFYHLASAPGNGSMVMPQDVEQALKQWEYNEKLAFYMFQEGMLERHEYLTWILDVLEKIRPVDDDLLKLLLPLMLQYSEEFVQSAYLSRRLAYFCARRLSLLLNDSPNLLAAHSPHMMIGPNNPGLSASSPAAPGPVMSPVQLSGSDLLSCPQHRPLVYGLSCMLQTVTLCCPSALVWNYSTNENKSVNPGSPLDLLQVAPSSLPMPGGNSAFNQQVRAKIYEVEQQIKRRGRAVEVRWSFDKCQESTAGVTISRVLHTLEVLDRHCFDRSDSSNSMETLYHKIFWATQNKDNQEVAPNDEAVVTLLCEWAVSCKRSGKHRAMAVAKLLEKRQAEIEAERCGESEVLDEKESLSSASLAGSSLPVFQNVLLRFLDTQAPSLSDPNSEYEKIEFVNLVLLFCEFIRHDVFSHDAYMCTLISRGDLSLSATTRPRSPPGENLDEHYSKDNDVKLEIFSPMPGESCENANSSLDRRISVNSEKMVKREKQRELIFPSNYDLLRHLQYATHFPIPLDESSSHECNQRTILLYGVGKERDEARHQLKKITRDILKILNKKSTPECGVEDEGQKARKSKQETFPTLETVFTKLQLLSYFDQHQVTSQISSNVLEQITSFASGTSYHLPLAHHIQLIFDLMEPALNINGLIDFAIQLLNELSVVEAELLLKSSSLAGSYTTGLCVCIVAVLRRYHACLILNPDQTAQVFEGLCGVVKHVVNPSECSSPERCILAYLYDLYVSCSHLRSKFGDLFSSACSKVKQTIYSNVQPSNSNLLWDPEFMLDFIENPSAHNVNYSMLGKILSDNAANRYSFVCNALMNVCMGHQDAERINDIANLCAELTACCTVLSSEWLGVLKALCCSSNHVWGFNDLLCSVDVSDLSFHDSLATFIAILIARQCFSLEDVVQHVALPSLLAAACGDPDAEPGARMTCRLLLHLFRTPQVCLLPQATGDAEIGSNSNANALKSEDFTMRGLLDDMNDEDIWSASQSMKPCGKVVSIETASLSEYARYVLRTICQQEWVGEHCLKEPERLCTDKDLILDPVLSHKQAQKLLQLICYPHGIKECTEGDDVQRQHIKRILQNLDQWTLRQSWLELQLMIKQCMKEPGSGSVAEMNCLLDNIAKTTIEVFQQSADLNNNSSNSGIGLFNPNAIGNGDTSNTRQNGKKAFLSSSERRGVWLVAPLIAKLPTSVQGRVLKAAGEELEKGQHLGSSSKKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLQNQVNQILSNWREERYQDDIKARQMMHEALQLRLNLVGGMFDTVQRSTQWTTDWALLLLQIITSGTVDMQTNNELFTTVLDMLGVLINGTLASDLSSSSQGGAEENKRAYMNLVKKLKKELGDKRSESIDKVRQLLPLPKQTCDVITCEPMGSLIDTKGNKIAGFDSIDKKQGLQVSTKQKVSPWDLFEGHKNPAPLSWAWFGTVRVDRKVIKYEEQHHLLLYHTHPTPKPRSYYLEPLPLPPEEEDEEPATPVSQEPERKSAELSDQGKTTADEEKKTKGRKRKTKSNSRVDEYPQNNIYRVPPNYSPISSQMMHHPQSALWGYNIMGQPQQPGFFLQNQSLAPGGSRLDPTGSFVPTNTKQALSNMLQRRSGTMMQPPSIHAITSQQQLIQMKLMQQQQQQQQQQQRLLRQQAQTRPFQQDFCNSAVPLQDGFDNIMGQPLDQAAIFPPQVRPSSQLPQYSGLQQAQAMPHGYTMYSTQMPLQPQQQAGGVVLSPGYNPRTYPATHSNPALMERLRQMQQQPPSGYIQQQAAAAAAYLQPLPGSQRLTHQPLQQSPLVGGGLDAVLTTAPHPNLNSVPLPQDQMRQRQQQIRQQRLLQLQQQQQQQPQQQQQQQQPQQQQQQQQQPQQQQQQQQQQQQPQGQQTLGLQPMQPQQPLFPRQGLQQTQQQQQTAALVRQLQKQLSSNQPQQGVTPYGHPSHF
Length1994
PositionKinase
OrganismSarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Metatheria> Dasyuromorphia> Dasyuridae> Sarcophilus.
Aromaticity0.06
Grand average of hydropathy-0.489
Instability index61.49
Isoelectric point6.32
Molecular weight224279.18
Publications
PubMed=21709235

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP28289
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|     508.33|      66|      66|    1620|    1685|       1
---------------------------------------------------------------------------
 1521- 1605 (41.15/11.41)	.......PKPRSYYLEPLPLP........PEEEDEEP.....AT...P......VSQ.EPERKSA.....ELSDqgkttadeekktkgrkrktksnsrvdeypqnniyrvPPNYSPISSQ.....
 1620- 1685 (113.37/44.70)	MG....QPQQPGFFLQNQSLA........PGGSRLDP.....TGSFVPTNTKQALSN.MLQRRSG.....TMMQ....................................PPSIHAITSQQQLIQ
 1689- 1753 (81.19/29.87)	MQ....QQQQQQ..QQQQRLL........RQQAQTRPfqqdfCNSAVPL..QDGFDNiMGQPLDQ.....AAIF....................................PPQVR...PSSQLPQ
 1769- 1807 (60.88/20.51)	MY....STQMP...LQPQQQA.........GGVVLSP.......GYNPRTYPATHSN.....................................................PA..........LME
 1812- 1877 (71.98/25.62)	M.....QQQPPSGYIQQQAAAaaaylqplPGSQRL...............THQPLQQ.SPLVGGGldavlTTAP....................................HPNLNSVPLPQD..Q
 1878- 1934 (95.03/36.25)	MR....QRQQQ...IRQQRLL............QLQQ.....QQQQQPQQQQQ..QQ.QPQQQQQ.....QQQQ....................................PQQQQQQQQQQQQPQ
 1939- 1983 (44.73/13.06)	LGlqpmQPQQPLF..PRQGLQ........Q.TQQQQQ.....TAALVRQLQKQLSSN.QPQQ...............................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     722.05|     181|     188|     698|     885|       2
---------------------------------------------------------------------------
  395-  660 (213.14/138.53)	LSSASLAGSSLPVFQNVLLRFLDT.QAPS..LSDPNSEYEKIEfvnlvlLFCEFIRHDVFSH....D...AYMCTLISRGDLSLSaTT...RP.RSPPGENLDEHYSKdndVKLEIFSPmpgescenanssldrrisvnsekmvkrekqrelIFPSNYDLLRHLQY....ATHFpipLDESSSHECNQRT..IllygvGK.ERDEARHQLKkitrdilkilnkkstpecgvedegqkarkskqetfptletvFTKLQLLSYFDQHQVTSQ.IS..SNVLEQITSFASGTS
  705-  885 (314.68/223.81)	LKSSSLAGSYTTGLCVCIVAVLRRYHACL..ILNPDQTAQVFE......GLCGVVKHVVNPS....ECSSPERCILAYLYDLYVS.CS...HL.RSKFGDLFSSACSK...VKQTIYSN.................................VQPSNSNLLWDPEF....MLDF...IENPSAHNVNYSM..L.....GKILSDNAANRYS.........................................FVCNALMNVCMGHQDAER.INDIANLCAELTACCTVLS
  905- 1072 (194.24/127.87)	.........FNDLLCSVDVSDL.SFHDSLatFIAILIARQCF.......SLEDVVQHVALPSllaaACGDPDAEPGARM.....T.CRlllHLfRTPQVCLLPQATGD...AE..IGSN....................................SNANALKSEDFtmrgLLDD...MNDEDIWSASQSMkpC.....GKVVSIETASLSE.........................................YARYVLRTICQQEWVGEHcLKEPERLCTD.........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      90.74|      26|      85|    1110|    1137|       3
---------------------------------------------------------------------------
 1110- 1135 (47.72/29.41)	RQHIKRILQNLDQWTLRQSWLELQLM
 1329- 1354 (43.02/20.48)	VGGMFDTVQRSTQWTTDWALLLLQII
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     251.75|      98|     179|    1200|    1303|       4
---------------------------------------------------------------------------
 1200- 1259 (71.22/50.86)	............................................................................................................NGKKAFLSS....SERRGVWLVAPL.IAKLPT.SVQGRVLKaaGEELEK..........GQHLGSSSKKERDRQKQ
 1260- 1303 (36.09/27.87)	KSMSLLSQQPFLSLVLT...CLKGQD..EQREGLLTSLQNQVnqilSNW.......................................................................................................................................
 1363- 1426 (53.94/31.40)	.................................................reeryqddikarqmmhealqlrlnlvggmfdtvqrstqwttdwallllqiitsgtvdmqTNNELFTTV....LDMLGVLINGTL.ASDLSS.SSQG......GAEENKraymnlvkklKKELGDKRSESIDKVRQ
 1433- 1512 (90.49/60.99)	QTCDVITCEPMGSLIDTkgnKIAGFDsiDKKQGLQVSTKQKV....SPW....................................................................dlfeGHKNP....APLsWAWFGTvRVDRKVIK.....YEE..........QHHL.............
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.24|      22|     251|     248|     272|       5
---------------------------------------------------------------------------
  248-  272 (34.07/31.00)	MPG.....GNSAFNQQVRAkiyEVEQQIKR
  500-  526 (32.17/19.88)	MPGescenANSSLDRRISV...NSEKMVKR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28289 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) PGFFLQNQSLAPGGSRLDPTGSFVPTNTKQALSNMLQRRSGTMMQPPSIHAI
2) PQQQAGGVVLSPGYNPRTYPATHSNPALMERLRQMQQQPPSGYIQQQAAAAAAYLQPLPGSQRLTHQPLQQSPLVGGGLDAVLTTAPHPNLNSVPLPQDQMRQRQQQIRQQRLLQLQQQQQQQPQQQQQQQQPQQQQQQQQQPQQQQQQQQQQQQPQGQQTLGLQPMQPQQPLFPRQGLQQTQQQQ
3) RSYYLEPLPLPPEEEDEEPATPVSQEPERKSAELSDQGKTTADEEKKTKGRKRKTKSNSRVDEYPQNNIYRVPPNYSPISSQMMHHPQSALWGYNIMGQP
1626
1778
1524
1677
1963
1623










Molecular Recognition Features






MoRF SequenceStartStop




1) RSYYLEPLPLP
1524
1534