<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28283
Description |
Mediator of RNA polymerase II transcription subunit 16 |
Sequence | QAGDPRNQSRGMMDLAYVCEWEKRPKSNHCPSIPLVCAWSCRNLIAFTTDLKNEEEKDTMMVKVLSPVTPMIFIHFHKVPHLLPPPISPTLASLSGSRLLSADADGHVKCWSMTDHLANSWENTVGSMVEGDPIVSLSWLHNGVKLALHVEKSGASSFGDKFSRVKFSPSLTLFGGKPMEGWIAVTISGLVIVSLLKPNGQVLTSTESLCRLRCRVALADIAFTGGGNIVVATSDGSSTSPVQFYKVCVSVVNEKCRIDTEILPSLFMRCTTDPARKDKYPAITHLKFLARDMSEQVLLCASNQMNSIVECWSLRKEGLPVNNIFQQISPVVGDKQPMILKWRILSATNDLDRVSAVALPKLPISLTNTDLKVANDTKFCPGLGLALAFHDGSVHIVHRLSLQTMAMFYGSSTQRPVDEPSIKRQRTAGPSIHFKAMQLSWTSLALVGIDNHGKLSMLRISPSMGHALDMNMSLRHLLFLLEYCMVTGYDWWDILLHVQPNMVQNLVEKLHEEYMRQNAALQQVLSTRIVAMKASLCKLSSCTVARVCDYHAKLFLIAISSTLKSLLRPHFLNTPDKSPGDRLTEICSKITDVDIDKVMINLKTEEFVLEMTTLQSLQQLIQWVGDFVLYLLASLPNQGSPVRPGHSFLRDGASLGMLRELMVVIRIWGLLKPSCLPIYTATSDTQDSMSLLFRLLTKLWLCCRDENHPSEPDETLIDECCLLPSQLLIPSLDWLPISDGIISKLQSKQLVRLQFGKAPGLLGYAGAPPFEVLARAPGQPKIDHLRRLHLGAYPTEECKSCTRCGCVTVLRSPHKATAVKQWEQRWTKNCL |
Length | 831 |
Position | Tail |
Organism | Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia>
Metatheria> Dasyuromorphia> Dasyuridae> Sarcophilus.
|
Aromaticity | 0.06 |
Grand average of hydropathy | 0.014 |
Instability index | 46.33 |
Isoelectric point | 8.60 |
Molecular weight | 92410.90 |
Publications | PubMed=21709235
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364149
|
GO - Cellular Component | mediator complex GO:0016592 IEA:Ensembl
|
GO - Biological Function | thyroid hormone receptor binding GO:0046966 IEA:Ensembl
transcription coactivator activity GO:0003713 IEA:Ensembl
|
GO - Biological Process | positive regulation of transcription initiation from RNA polymerase II promoter GO:0060261 IEA:Ensembl
|
Interaction
Repeat regions
Repeats |
>MDP28283
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 92.07| 30| 189| 285| 328| 1
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91- 134 (46.19/16.40) LA.SLSGSRLL..SADADGHVKCWSMTDhlanswentvgsmvEGDPI
289- 321 (45.88/34.89) LArDMSEQVLLcaSNQMNSIVECWSLRK..............EGLPV
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