<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28264

Description Mediator of RNA polymerase II transcription subunit 15
SequenceSRGVRRRSDQPRRPRVWGARGENGYNFICKLRQGLGTLTVRLSEEAMRKAGVAHSKSSKDMESHVFLKAKTRDEYLSLVARLIIHFRDIHNKKSQASVSDPMNALQNLTGGPPTGATGIGMASRGPGQSLGGISGLAGVGQSMALSGQPPPGTSAMPPHGMSVVSATTQPTQLQLQQVALQQQQQQQQQFQAQQSAMQQQQQQFQVAGQQQEQQLQVAVQQQQQDLLKFHHQSQQQVRRQRKQSNPIAFSKLQQQQQLRIAQLQLQHQQQQAMQPQPPPQQQPPSQAPPASQAMQQQLQQLHHPQQHQPPPQQPQQVAQQQQPQLPPQAPPPQPLVPQAQSIPGQMMLTPQQLKVMQVRAQMVVQQAQQAQQQQQQQQQQQQQQQQVAAAQAAQVNQTSMTMMSSPSPVQQAQTPQAMPPPPQPSPQPGQPSSQPNSNVSSGPAPSPSSFLPSPSPQPSQSPASARTPQTFSVPSPGPLNTPVNPSSVLSPASSSQAEEQQYLEKLKQLSKYIEPLRRMINKIDKNEERKKDLSKMKSLLDILTDPSKRCPLKTLQKCEIALEKLKNDMAVPTPPPPPVPPTKQQYLCQPLLDAVLANIRSPVFNHSLYRTFVPAMEAIHGPPITAPVISPRKRKYEDDEKQTIPNVLQGEVARLNPKFLVNLNPSHCSNNGTVHLICKLVIHLLPPPPP
Length690
PositionTail
OrganismSarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Metatheria> Dasyuromorphia> Dasyuridae> Sarcophilus.
Aromaticity0.03
Grand average of hydropathy-0.802
Instability index87.06
Isoelectric point10.16
Molecular weight76109.72
Publications
PubMed=21709235

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364148
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP28264
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      93.58|      26|      29|     278|     305|       1
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  183-  208 (40.89/ 7.32)	QQQQQQQFQAQQS..AMQQQQQQFQVAG
  278-  305 (52.69/15.57)	PPQQQPPSQAPPAsqAMQQQLQQLHHPQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     160.90|      27|      30|     220|     246|       2
---------------------------------------------------------------------------
  220-  246 (43.36/ 9.15)	Q.............QQQ...QDLLKFHHQSQQQVRRQRKQSNP
  292-  334 (37.93/ 6.79)	QamqqqlqqlhhpqQHQpppQQPQQVAQQQQPQLPPQAPPPQP
  349-  375 (38.61/ 7.08)	T.............PQQ...LKVMQVRAQMVVQQAQQAQQQQQ
  411-  436 (41.01/ 8.12)	Q.............AQT...PQAMPPPPQPSPQPGQPSSQPN.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.63|      23|      27|     126|     148|       8
---------------------------------------------------------------------------
  126-  148 (41.59/22.28)	PGQSL...GGISGLAGVGQSMALSGQ
  151-  176 (33.05/16.14)	PGTSAmppHGMSVVSATTQPTQLQLQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.98|      18|      28|     498|     518|      10
---------------------------------------------------------------------------
  510-  538 (13.86/19.57)	SKYIePLRRminkidkneERKKdLSKMKS
  547-  567 (27.12/14.63)	SKRC.PLKT......lqkCEIA.LEKLKN
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28264 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GVGQSMALSGQPPPGTSAMPPHGMSVVSATT
2) HNKKSQASVSDPMNALQNLTGGPPTGATGIGMASRGPGQSLGGISGL
3) LQLQHQQQQAMQPQPPPQQQPPSQAPPASQAMQQQLQQLHHPQQHQPPPQQPQQVAQQQQPQLPPQAPPPQPLVPQAQSIPGQMMLTPQQLKVMQVRAQMVVQQAQQAQQQQQQQQQQQQQQQQVAAAQAAQVNQTSMTMMSSPSPVQQAQTPQAMPPPPQPSPQPGQPSSQPNSNVSSGPAPSPSSFLPSPSPQPSQSPASARTPQTFSVPSPGPLNTPVNPSSVLSPASSSQAEEQQYLEKLKQ
4) QQQQQDLLKFHHQSQQQVRRQRKQSNPIAFSKLQ
138
90
263
220
168
136
508
253










Molecular Recognition Features






MoRF SequenceStartStop




NANANA