<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28263

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMSGVRAVRISIESACEKQVQEVGLDGTETSLQPLSMSQNLARLAQRIDFSQGSGSEEEEAPGADRDSQDWAGTSGGADGAEQDDEEGLVKFQPSLWPWDSVRNNLRSSLTEMCVLYDVLSIIRDKKFMTLDPVSQDSLPPKQNPQTLQLISKKKSLAGAAQILLKGADRLTKSVTENQENKRQRDFNSELLRLRQHWKLRKVGDKILGDLSYRSAGSLFPHHGTFEVIKNTDIDLDKKIPEDYCPLDVQIPSDLEGSAYIKVSIQKQASDIGDLGTVNLFRRPMPKSKPGSPHWQTKLEAAQNVLLCKEIFAQLSREAVQIKSQIPHIVVKNQIISQPFPSLQLSISLCHSSNDKKSQKSSEKQSAEDHLYVLEHNLHQLIREFHKQTLSSTMMPHPASAPFGHKRMRLSGPQAFDKNEINSLQSSEGLLEKIIKQAKHIFLRSRRTAQTIDTLASRIEDPQIQAHWSNINDVYESSVKVLITSQGYEQICKSIQLQLNIGVEQIRVVHRDGRVITLSHQEQELQDFLLSQMSQHQVHAVQQLAKVMGWQVLSFSNHAGLGPVESIGNASAITVASPSGDYAISVRNGPESGSKVMVQFPRSQCKDLPKSDVLQDGKWNHLRGPFKEVQWNKMEGRNFVYKMELLMSALTPCS
Length653
PositionHead
OrganismSarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Metatheria> Dasyuromorphia> Dasyuridae> Sarcophilus.
Aromaticity0.06
Grand average of hydropathy-0.512
Instability index56.98
Isoelectric point7.67
Molecular weight73097.09
Publications
PubMed=21709235

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:Ensembl

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro
stem cell population maintenance	GO:0019827	IEA:Ensembl









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP28263
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     236.10|      46|     109|     283|     328|       2
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  220-  258 (34.96/16.84)	.........PHH...GT.FEVIKNtdIDL........DKKIPEDYCPLDV..QIPSDLEgSA
  283-  328 (79.11/46.92)	PMPKSKPGSPHW...QTKLEAAQN..VLL........CKEIFAQLSREAV..QIKSQIP.HI
  352-  383 (30.42/13.75)	SNDKKSQKSSEK...QS...AEDH..LYV........LEHNLHQLIRE..............
  395-  440 (57.51/32.21)	PHPASAPFG.HK...RMRLSGPQ...AFD........KNEINSLQSSEGLleKIIKQAK.HI
  457-  506 (34.10/16.26)	RIEDPQI.QAHWsniNDVYESSVK..VLItsqgyeqiCKSIQLQLNIGVE..QIR.......
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28263 with Med17 domain of Kingdom Metazoa
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