<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28260

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMFYFYRKIEIVQFASRTRQLFVRLLALVKWANNAGKVEKCAMISSFLDQQAILFVDTADRLASLARDALVHARLPSFAIPYAIDVLTTGSYPRLPTCIRDKIIPPDPITKTEKQTTLHQLNQILRHRLVTTDLPPQLANLTVANGRVKFRVEGEFEATLTVMGDDPDVPWRLLKLEILVEDKETGDGRALVHSMQISFIHQLVQSRLFADDKPLQDMYNCLHSFCLSLQLEVLHSQTLMLIRERWGDLVQVEKYHAGKCLSLTVWNQQVLGRKTGIASVHKVTIKIDENDVSKPLQIFHDPPLPASDSKLVERAMKIDHLSIEKLLIDSVHARSHQKLQELKSILKGFNANENSFIETALPTLVVPILEPCSRSECLHIFVDLHSGMFQLMLYGLDQATLDDIEKSVNDDMKRIIPWIQQLKFWLGQQRCKQSIKHLPIMCSETLQLSNYSTHPVGNLSKNKLFIKLTRLPQYYIVVEMFEVPSNPTELEYKYHFLSVSSAEGDESPATALLLQQFKTNIEERLLDPKAGKQVRAGVKRKLSGDPNPVEPKKLKQSGEMCAFNKVLAHFVAVCDTNMPFIGLRMELCNMEIPHQGVQVEGDGFSHAIRLLKIPPCKGTSEETQKALDRALLDCTFRLQGRNNRTWVAELVFANCPLSSTSTREQGPTRHVYLTYENLLSEPVGGRKVVEMFLNDWNSIAQLYECVLEFARSLPDIPAHLNIFSEVRVYNYRKLILCYGTTKGSSISIQWNSSHQKFNISLGTVGPNSGCSNCHNTILHQLQEMFNKTPNVVQLLQVLFDTQAPLNAINKLPTVPMLGLTQRTNTAYQCFSILPQSSTHIRLAFRNMYCIDIYCRSRGVVAIRDGAYSLFDNSKIVEGFYPAPGLKTFLNMFVDSNQDARRRSVNEDDNPPSPIGGDMMDSLISQLQPQAPPQQQPFPKQPGSSGAYPLTSPPTSYHNTVNQSPSMMHTQSPGNLHAASSPSGALRAPSPASFVPTPPPSSHGISIGPGASFASPHGTIDPSSPYTMVSPSGRAGNWPGSPQLSGPSPATRMPGMSPANPSLHSPVPDVSHSPRAGTKKGSQAMPTNMPPPRKLPQRSWAASIPTILTHSALNVLLLPSPTPGLVPGLAGSYLCSPLERFLGSVIMRRHLQRIIQQETLQLINSNEPGVIMFKTDALKCRVALSPKTNQTLQLKVTPENAGQWKPDELQVLEKFFETRVAGPPFKANTLIAFTKLLGAPTHILRDCVHIMKLELFPDQATQLKWNVQFCLTIPPSAPPIAPPGTPAVVLKSKMLFFLQLTQKTSVPPQEPVSIIVPIIYDMASGTTQQADIPRQQNSSVAAPMMVSNILKRFAEMNPPRQGECTIFPAVRDLMANLTLPPGGRP
Length1383
PositionTail
OrganismSarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Metatheria> Dasyuromorphia> Dasyuridae> Sarcophilus.
Aromaticity0.07
Grand average of hydropathy-0.199
Instability index52.53
Isoelectric point8.93
Molecular weight153745.96
Publications
PubMed=21709235

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU365082
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP28260
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      94.54|      27|      32|     177|     208|       1
---------------------------------------------------------------------------
  180-  206 (45.63/32.82)	EDKETGDGRALVHSMQISFIHQLVQSR
  210-  236 (48.91/21.62)	DDKPLQDMYNCLHSFCLSLQLEVLHSQ
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     102.18|      33|     508|     254|     304|       2
---------------------------------------------------------------------------
  140-  174 (53.14/21.10)	LTVANGRVKFRVEG...EFEATLTVmgDDPDV..PWRLLK
  262-  299 (49.05/38.54)	LTVWNQQVLGRKTGiasVHKVTIKI..DENDVskPLQIFH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     260.13|      83|     508|     419|     550|       3
---------------------------------------------------------------------------
  445-  530 (132.88/131.99)	LQLSNYSTHPVGNLSKNKLF.ikLTRLPQYYIVVEMF..EVPSNPTELE.......YKYH..FLSVSSAEGDeSPATALLLQQFKTNIEERLLDPKAG
  672-  768 (127.24/52.30)	LTYENLLSEPVGGRKVVEMFlndWNSIAQLYECVLEFarSLPDIPAHLNifsevrvYNYRklILCYGTTKGS.SISIQWNSSHQKFNISLGTVGPNSG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.86|      17|     508|     103|     119|       4
---------------------------------------------------------------------------
  103-  119 (31.58/20.34)	IPPDPITKTEKQTTLHQ
  612-  628 (31.29/20.07)	IPPCKGTSEETQKALDR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     235.58|      36|      36|     972|    1007|       5
---------------------------------------------------------------------------
  911-  940 (35.50/13.05)	.......SPIGGDMMD..SLISqL...QPQ..APPQQQPFPKQP
  941-  970 (24.60/ 6.56)	.....GSSGAYPLTSP...PTS.YhntVNQ..SPSMMHTQS...
  972- 1007 (66.49/31.52)	GNLHAASSPSGALRAP..SPAS.F...VPT..PPPSSHGISIGP
 1043- 1066 (29.93/ 9.73)	......SGPSPATRMPgmSPAN............PSLH..SPVP
 1067- 1094 (38.91/15.08)	DVSH...SPRAGTKKG..SQA......MPTnmPPPRKL.....P
 1095- 1126 (40.15/15.82)	QRSWAASIPTILTHSA..LNVL.L...LPS..PTP...GLVPG.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      82.60|      25|      25|    1292|    1316|       6
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 1292- 1316 (41.99/21.48)	MLFFLQLTQKTSVPPQEPVSIIVPI
 1318- 1342 (40.61/20.53)	YDMASGTTQQADIPRQQNSSVAAPM
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.27|      23|     165|    1018|    1041|       7
---------------------------------------------------------------------------
 1018- 1041 (42.32/22.71)	IDPSSPYTM...VSPSGrAGNW.PGSPQ
 1182- 1208 (33.96/13.94)	LSPKTNQTLqlkVTPEN.AGQWkPDELQ
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28260 with Med14 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) NQDARRRSVNEDDNPPSPIGGDMMDSLISQLQPQAPPQQQPFPKQPGSSGAYPLTSPPTSYHNTVNQSPSMMHTQSPGNLHAASSPSGALRAPSPASFVPTPPPSSHGISIGPGASFASPHGTIDPSSPYTMVSPSGRAGNWPGSPQLSGPSPATRMPGMSPANPSLHSPVPDVSHSPRAGTKKGSQAMPTNMPPPRKLPQRSWA
895
1099










Molecular Recognition Features






MoRF SequenceStartStop




NANANA