<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28257

Description Mediator complex subunit 12
SequenceSGPSASFSLPPQISSNFSSIIAEKLRCNTLPDTGRRKPQVNQKDNFWLVTARSQSAIHAWFTDLAGTKPLTHLAKKVPIFGKKEEVFGYLAKYTVPVMRAAWLIKMTCAYYAAITETKVKKKHVIDPFMEWTQIITKYLWEQLQKMAEFYRPGPGSCVSASGSLPHEVETALRQWDYNEKLAMFMFQDGMLDRHEFLTWVLECFEKIRPGEDELLKLLLPLLLRYSGEFVQSAYLSRRLAYFCTRRLALQLDGVSGHPGHVLATQPGGTLPPTPAPQPPAGSQPSTPFGELLQCPQHRPLVFGLSCILQSILLCCPSALVWHYSLTDSRIKTGSPLDHLPIAPSNLPMPGGNSAFTQQVRAKLREIEQQIKERGQAVEVRWSFDKCQETTAGFTIGRVLHTLEVLDSHSFERSDFSNSLDSLCNRIFGLGPSKDGHEISPDDDAVVALLCEWAVSCKRSGRHRAMVVAKLLEKRQAEIEAERCGETEAVDEKGSISSGSLSAPTAPIFQDVLLQFLDTQAPMLTDPRSESERVEFFNLVLLFCELIRHDVFSHNIYTCTLISRGDLAFGAPGPRPPSPFDDPPDDPERKDTEGSSSSKLEDPGLSESMDIDPGSSTLFEDMEKPDFPMFSPTMHCEGKGSPSPEKPDGEKEMKPLLKEKVEGTLGILYEQPRHVQYATHFPIPQEESCSHECNQRLVVLFGVGKQRDDARHAIKKITKDILKVLNRKGTAETGPPLGCVPPHDCLSLLLPGGEDGQKRRRSRPEAFPTAEDIFSKFQHLSHYDQHQVTAQVSRNVLEQITSFALGMSYHLPLVQHVQFIFDLMEYSLSISGLIDFAIQLLNELSVVEAELLLKSSDLVGSYTTSLCLCIVAVLRHYHACLILNQDQMAQVFEGLCGVVKHGMNRSDGSSAERCILAYLYDLYTSCSHLKSKFGELFSDFCSKVKNTIYCNVEPSESNMRWAPEFMIDTLENPAAHTFTYYTGLGKSLSENPANRYSFVCNALMHVCVGHHDPDRVNDIAILCAELTGYCKALSAEWLGVLKALCCSSNNGTCGFNDLLCNVDVSDLSFHDSLATFVAILIARQCLLLEDLIRCAAIPSLLNAACSEQDSEPGARLTCRILLHLFKTPQLNPCQADGNKPAVGIRSSCDRHLLAASQNRIVDGAVFAVLKAVFVLGDAELKGSGFTLAGGADELPEEEGGGGRRPGGRSFSVETASLDVYAKYVLRSICQQEWVGERCLKSLCEDSNDLQDPVLSSAQAQRLMQLICYPHRLLDNEDGDNPQRQRIKRILQNLDQWTMRQSSLELQLMIKQTPNNEMNSLLENIAKATIEVFQQSAETGAAAGGPATTVPPSNNKAKPVLSSLERSGVWLVAPLIAKLPTSVQGHGLKAAGEELEKGQHLGSSSRKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLYSQVHQIVNNWRDDQYLDNCKPKQLMHEALKLRLNLVGGMFDTVQRSTQQTTEWAVLLLEIIISGTVDMQSNNELFTTVLDMLSVLINGTLAADMSSISQGSMEENKRAYMNLVKKLRKELGERQSDSLEKVRQLLPLPKQTRDVITCEPQGSLIDTKGNKIAGFDSIFKKESGQGLQVSTKQKISPWDLFEGLKPSAPLSWGWFGTVRVDRRVARGEEQQRLLLYHTHLRPRPRSYYLEPLPLPPEDEEPPAPVLLEPDKKAPEPPKPDKTGPAPPSTEERKKKPPKSKKRPQAANKTEDYGLGPGRSGSYVPVPTDLLHHAPGSSISRFGYPQTPVTLYTQNQPLPAGGPRLDTTYRPVRMPVPKLQTRPSYSGVLPSPITGVISIDPSYKTPVYRQQQPPVPQGQLLRQQLQAKLSQGMLGQPPVRQMTPNSSYGSLQASQGYTPYGSHIGLQQHTGPAGTMVPPSYSSQPYQSPHPAANPTLVDPARHLQQRPSGYVHQQAPGYGHGLPTTQRFAHQSLQQTSMMGTMTPLSAQGVPAGVRPSPILPEQQQQQQQQQQQQQQQQQQQQQQQQYHIRQQQQQQQILRQQQQQQQQQQQQQQQQQQQQQQ
Length2057
PositionKinase
OrganismSarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Metatheria> Dasyuromorphia> Dasyuridae> Sarcophilus.
Aromaticity0.07
Grand average of hydropathy-0.439
Instability index57.91
Isoelectric point6.70
Molecular weight228791.82
Publications
PubMed=21709235

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:Ensembl

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
chromatin binding	GO:0003682	IEA:Ensembl
protein C-terminus binding	GO:0008022	IEA:Ensembl
protein domain specific binding	GO:0019904	IEA:Ensembl
RNA polymerase II cis-regulatory region sequence-specific DNA binding	GO:0000978	IEA:Ensembl
thyroid hormone receptor binding	GO:0046966	IEA:Ensembl
transcription coactivator activity	GO:0003713	IEA:Ensembl

GO - Biological Process
axis elongation involved in somitogenesis	GO:0090245	IEA:Ensembl
canonical Wnt signaling pathway	GO:0060070	IEA:Ensembl
embryonic brain development	GO:1990403	IEA:Ensembl
embryonic neurocranium morphogenesis	GO:0048702	IEA:Ensembl
endoderm development	GO:0007492	IEA:Ensembl
heart development	GO:0007507	IEA:Ensembl
neural tube closure	GO:0001843	IEA:Ensembl
oligodendrocyte development	GO:0014003	IEA:Ensembl
positive regulation of transcription initiation from RNA polymerase II promoter	GO:0060261	IEA:Ensembl
post-anal tail morphogenesis	GO:0036342	IEA:Ensembl
Schwann cell development	GO:0014044	IEA:Ensembl
spinal cord development	GO:0021510	IEA:Ensembl
stem cell population maintenance	GO:0019827	IEA:Ensembl
Wnt signaling pathway, planar cell polarity pathway	GO:0060071	IEA:Ensembl









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP28257
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     201.21|      35|      39|    1983|    2018|       1
---------------------------------------------------------------------------
 1821- 1861 (33.08/ 8.84)	.....GVLPSPITgvisidpsyktPVYRQQQPPVPQGQL...LRQQLQA
 1863- 1890 (28.92/ 9.90)	..LSQGMLGQP.............PVRQMTPNSSYGSLQ...ASQG...
 1903- 1939 (45.53/12.96)	HTGPAGTMVPPSY...........SSQPYQSPHPAANP.tlvDPARHLQ
 1983- 2015 (58.96/19.50)	QGVPAGVRPSPIL...........PEQQQQQQQQQQQQQ...QQQQQ..
 2034- 2056 (34.71/ 9.63)	............L...........RQQQQQQQQQQQQQQ...QQQQQQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     127.46|      40|     155|       2|      47|       2
---------------------------------------------------------------------------
    2-   47 (64.50/53.10)	GP....SASFSLPPQISSNFSSI.IAEKLRCNTLPDtGrrkpqVNQKDNF..W
  153-  199 (62.96/36.58)	GPgscvSASGSLPHEVETALRQWdYNEKLAMFMFQD.G.....MLDRHEFltW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     106.53|      31|      44|     868|     909|       3
---------------------------------------------------------------------------
  868-  899 (52.92/53.17)	CIVAVLRH.YHACLILnQDQMAQVFEGLCGVVK
  913-  944 (53.61/27.27)	CILAYLYDlYTSCSHL.KSKFGELFSDFCSKVK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     181.36|      44|      45|    1690|    1733|       4
---------------------------------------------------------------------------
 1690- 1733 (83.85/36.25)	PPEDEEPPAPVLLEPDKKAPEPPKP.DKTGPAPPSTEERKKKP.PK
 1737- 1775 (49.95/18.62)	RPQAANKTEDYGLGPGRSGSYVPVPtDLLHHAPGSSISR.......
 1779- 1812 (47.55/17.37)	......PQTPVTLYTQNQ....PLP..AGGPRLDTTYRPVRMPvPK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     306.89|      96|     139|     587|     689|       5
---------------------------------------------------------------------------
  587-  689 (154.59/95.98)	ERKDT.EGSSSSKLEDPGLSESMDIDPGSSTLFEDMEKPD.FP....MFSPTMHCegkgSPSPEKPDGEKEMKPLLKEKVEGTLGILYEQP..RHVQYAthFPIpQEESCS
  725-  828 (152.29/78.09)	NRKGTaETGPPLGCVPPHDCLSLLLPGGEDGQKRRRSRPEaFPtaedIFSKFQHL....SHYDQHQVTAQVSRNVLEQITSFALGMSYHLPlvQHVQFI..FDL.MEYSLS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.08|      15|      23|    1494|    1516|       6
---------------------------------------------------------------------------
 1488- 1502 (24.81/ 6.10)	TVQRSTQQTTEWAVL
 1511- 1525 (25.27/20.69)	TVDMQSNNELFTTVL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.48|      11|     108|    1245|    1255|       7
---------------------------------------------------------------------------
 1245- 1255 (20.52/12.51)	SNDLQDPVLSS
 1351- 1361 (19.96/11.94)	SNNKAKPVLSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     105.59|      32|     148|     398|     443|       9
---------------------------------------------------------------------------
  217-  249 (50.29/25.38)	LLLPLLLRYSGEFVQSAYlSRRLAYFCTRRLAL
  398-  429 (55.31/39.53)	VLHTLEVLDSHSFERSDF.SNSLDSLCNRIFGL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.21|      18|      21|    1596|    1616|      10
---------------------------------------------------------------------------
 1596- 1615 (23.31/30.80)	QGSLIDTKgNKIAGFDsIFK
 1620- 1637 (33.90/22.10)	QGLQVSTK.QKISPWD.LFE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     140.27|      32|      49|    1025|    1056|      15
---------------------------------------------------------------------------
  981- 1011 (43.67/24.76)	.TGLGKSLS.ENPANRYSFV.CNAL....MHVCvGHHD
 1025- 1056 (58.06/35.34)	LTGYCKALSAEWLGVLKALC.CSSN....NGTC.GFND
 1072- 1108 (38.54/20.98)	LATFVAILIARQCLLLEDLIrCAAIpsllNAAC.SEQD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.12|      18|     570|    1383|    1400|      16
---------------------------------------------------------------------------
 1383- 1400 (32.32/22.58)	GHGL....KAAGEELEKGQHLG
 1954- 1975 (28.80/19.12)	GHGLpttqRFAHQSLQQTSMMG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28257 with Med12 domain of Kingdom Metazoa
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