<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28251

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMDVSGQETDWRSAAFRQKLVSQIEDAMRKAGVAHSKSSKDMESHVFLKAKTRDEYLSLVARLIIHFRDIHNKKSQASVSDPMNALQSLTGGPTPGAAGIGMPPRGPGQSLGGMGGLGAMGQPLPLSGQPPPGTSGMAPHGMAVVSTATPQTQLQLQQVALQQQQQQQQQQFQQQQAALQQQQQQQQQQQQQQQFQAQQNAMQQQFQAVVQQQQLQQQQQQQHLIKLHHQSQQQQMQQQQQLQRMAQLQLQQQQQQQQQQQALQAQPPMQQPPMQQPQPPPSQALPQQLSQMHHPQHHQPPPQAQQSPVAQNQPPQLQPQSQNQPLVSQAQALSGPMLYAAQQPLKFVRPPMVVQQPQVQPQVQQVQPQVQPQAAVQTAQSAQMVAPGVQMIAEALAQGGMHVRARFPPTSTMSAGPSSSISLGGQPTAQVSQSSLTMLSSPSPGQQVQTPQSMPPPPQPSPQPGSQPNSNVSSGPAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLDKLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLDILTDPSKRCPLKTLQKCEIALEKLKNDMAVPTPPPPPVLPTKQQDLCQPLLDAVLANIRSPVFNHSLYRTFVPAMMAIHGPPIVSPVVCSRKRRFEEDERQSIPNVLQGEVARLDPKFLVNLDPSHCSNNGTVHLICKLDDKDLPSVPPLELSVPADYPAQSPMWVDRQWQYDANPFLQSVHRCMTSRLLQLPDKHSVTALLNTWAQSIHQACLSAA
Length790
PositionTail
OrganismRattus norvegicus (Rat)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Glires> Rodentia> Myomorpha> Muroidea> Muridae> Murinae> Rattus.
Aromaticity0.03
Grand average of hydropathy-0.693
Instability index87.74
Isoelectric point9.39
Molecular weight86795.54
Publications
PubMed=15057822
PubMed=15632090
PubMed=22673903

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
nucleoplasm	GO:0005654	IEA:Ensembl

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro
stem cell population maintenance	GO:0019827	ISO:RGD









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP28251
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     361.02|      63|      64|     136|     198|       1
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  136-  193 (100.99/20.15)	.........M............APHGMAVVSTATPQTQLQL.Q.QVALQQQQQQQQQQFQQQQAALQQQQQQQQQQQQQQQ
  194-  240 (62.55/ 9.02)	FQAQQ..naM.............................QQ.QfQAVVQQQQLQQQQQ.QQHLIKLHHQSQQQQMQQQQQ.
  280-  323 (63.06/ 9.17)	.............................PSQALPQ...QL.S.QM...HHPQHHQPPPQAQQSPVAQNQPPQLQPQSQNQ
  327-  390 (61.11/ 8.60)	SQAQAlsgpMlyaaqqplkfvrPP..MVV...QQPQVQPQV.Q.QV.........QPQV.QPQAAVQTAQSAQMVAPGVQM
  391-  453 (73.30/12.13)	IAE.....aL............AQGGMHVRARFPPTSTMSAgP.SSSISLGGQPTAQVSQSSLTMLSSPSPGQQVQTPQSM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.63|      16|      19|     479|     495|       2
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  479-  495 (30.76/10.04)	PSSFlPSPSPQPSQSPV
  500-  515 (30.87/ 7.42)	PQNF.SVPSPGPLNTPV
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---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.16|      16|      22|     241|     258|       4
---------------------------------------------------------------------------
  241-  258 (24.41/11.68)	LQrmAQLQLQQQQQQQQQ
  262-  277 (33.75/11.94)	LQ..AQPPMQQPPMQQPQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.25|      20|      22|     616|     635|       5
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  616-  635 (34.52/14.18)	QQDLCQPLLDAVLA....NIRSPV
  637-  660 (29.73/11.27)	NHSLYRTFVPAMMAihgpPIVSPV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.54|      24|      26|     562|     586|       6
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  562-  585 (41.50/22.77)	KKDLSKMKSLLDILTDPSKRC.PLK
  591-  615 (38.03/16.13)	EIALEKLKNDMAVPTPPPPPVlPTK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.79|      11|      26|     748|     758|       8
---------------------------------------------------------------------------
  748-  758 (23.12/17.32)	NPFLQSVHR.CM
  776-  787 (18.67/12.32)	NTWAQSIHQaCL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.08|      18|      22|     684|     701|       9
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  684-  701 (32.84/19.06)	VARLDPKFLVNLDPSHCS
  709-  726 (32.24/18.58)	ICKLDDKDLPSVPPLELS
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28251 with Med15 domain of Kingdom Metazoa
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