<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28249
Description |
Mediator of RNA polymerase II transcription subunit 15 |
Sequence | MRKAGVAHSKSSKDMESHVFLKAKTRDEYLSLVARLIIHFRDIHNKKSQASVSDPMNALQSLTGGPAAGAAGIGMPPRGPGQSLGGMGSLGAMGQPMSLSGQPPPGTSGMAPHSMAVVSTATPQTQLQLQQVALQQQQQQQQFQQQQQAALQQQQQQQQQQQFQAQQSAMQQQFQAVVQQQQQLQQQQQQQQHLIKLHHQNQQQIQQQQQQLQRIAQLQLQQQQQQQQQQQQQQQQALQAQPPIQQPPMQQPQPPPSQALPQQLQQMHHTQHHQPPPQPQQPPVAQNQPSQLPPQSQTQPLVSQAQALPGQMLYTQPPLKFVRAPMVVQQPPVQPQVQQQQTAVQTAQAAQMVAPGVQVSQSSLPMLSSPSPGQQVQTPQSMPPPPQPSPQPGQPSSQPNSNVSSGPAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLDKLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLDILTDPSKRCPLKTLQKCEIALEKLKNDMAVPTPPPPPVPPTKQQYLCQPLLDAVLANIRSPVFNHSLYRTFVPAMTAIHGPPITAPVVCTRKRRLEDDERQSIPSVLQGEVARLDPKFLVNLDPSHCSNNGTVHLICKLDDKDLPSVPPLELSVPADYPAQSPLWIDRQWQYDANPFLQSVHRCMTSRLLQLPDKHSVTALLNTWAQSVHQACLSAA |
Length | 722 |
Position | Tail |
Organism | Homo sapiens (Human) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia>
Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini> Hominidae>
Homo.
|
Aromaticity | 0.03 |
Grand average of hydropathy | -0.735 |
Instability index | 90.06 |
Isoelectric point | 9.50 |
Molecular weight | 79599.43 |
Publications | PubMed=10591208
PubMed=11181995
PubMed=18669648
PubMed=19413330
PubMed=21269460
PubMed=23186163
PubMed=24275569
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364148
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
nucleoplasm GO:0005654 IDA:HPA
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP28249
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
6| 367.88| 43| 43| 151| 193| 1
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151- 193 (80.40/17.64) LQQQ...Q..QQQQQ...QQFQAQQSAMQQQFQAVVQQQQQLQQQQQQQQH
197- 237 (68.37/13.37) LHHQ...N..QQQIQ...QQQQQLQRIAQLQLQQ..QQQQQQQQQQQQQQA
238- 273 (58.36/ 9.81) LQAQ...PpiQQPPM...QQPQPPPS...QAL......PQQLQQMHHTQHH
274- 317 (55.26/ 8.70) ..QP...P..PQPQQppvAQNQPSQLPPQSQTQPLVSQAQALPGQMLYTQP
322- 363 (52.33/ 7.66) VRAPmvvQ..QPPVQ...PQVQQQQTAVQTA.QA...AQMVAPGVQVSQSS
364- 398 (53.15/ 7.95) LPML...S..SPSPG...QQVQTPQS.MPPPPQPSPQPGQPSSQ.......
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 84.87| 17| 19| 60| 76| 2
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60- 76 (32.62/16.01) QSLTGGPAAGAAGIGMP
82- 96 (29.38/13.65) QSLGGMGSLGA..MGQP
97- 110 (22.87/ 8.93) MSLSGQPPPGTSGM...
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 61.77| 17| 21| 408| 427| 3
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408- 425 (31.07/11.40) APSPSSFlPSPSPQPSQS
429- 445 (30.70/11.14) ARTPQNF.SVPSPGPLNT
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 74.40| 23| 28| 497| 523| 4
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488- 515 (35.23/21.13) DKNEdrkkdLSKMKSLLDILTDPSKRCP
520- 544 (39.17/15.84) QKCE...iaLEKLKNDMAVPTPPPPPVP
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|
Associated diseases