<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28244

Description Mediator complex subunit 12
SequenceMAAFGILSYEHRPLKRPRLGPPDVYPQDPKQKEDELTALNVKQGFNNQPAVSGDEHGSAKNVNFNPAKISSNFSSIIAEKLRCNTLPDTGRRKPQVNQKDNFWLVTARSQSAINTWFTDLAGTKPLTQLAKKVPIFSKKEEVFGYLAKYTVPVMRAAWLIKMTCAYYAAITETKVKKRHVIDPFMEWTQIITKYLWEQLQKMAEYYRPGPAGSGSCASTIGPLPHDVEVAIRQWDYNEKLAMFMFQDGMLDRHEFLTWVLECFEKIRPGEDELLKLLLPLLLRYSGEFVQSAYLSRRLAYFCTRRLALQLDGVSSHSSHVMSAQSTSTLPTTPAPQPPTTSTPSTPFSDLLMCPQHRPLVFGLSCILQTILLCCPSALVWHYSLTDSRIKTGSPLDHLPIAPSNLPMPEGNSAFTQQVRAKLREIEQQIKERGQAVEVRWSFDKCQEATAGFTIGRVLHTLEVLDSHSFERSDFSNSLDSLCNRIFGLGPSKDGHEISSDDDAVVSLLCEWAVSCKRSGRHRAMVVAKLLEKRQAEIEAERCGESEAADEKGSIASGSLSAPSAPIFQDVLLQFLDTQAPMLTDPRSESERVEFFNLVLLFCELIRHDVFSHNMYTCTLISRGDLAFGAPGPRPPSPFDDPADDSERKETEGSSSSKLEDPGLSESMDIDPSSSVLFEDMEKPDFSLFSPTMPCEGKGSPSPEKPDVEKEVKSQPKEKIEGTLGVLYDQPRHVQYATHFPIPQEESCSHECNQRLVVLFGVGKQRDDARHAIKKITKDILKVLNRKGTAETDQLAPIVPLNPGDLTFLGGEDGQKRRRNRPEAFPTAEDIFAKFQHLSHYDQHQVTAQVSRNVLEQITSFALGMSYHLPLVQHVQFIFDLMEYSLSISGLIDFAIQLLNELSVVEAELLLKSSDLVGSYTTSLCLCIVAVLRHYHACLILNQDQMAQVFEGLCGVVKHGMNRSDGSSAERCILAYLYDLYTSCSHLKSKFGELFSDFCSKVKNTIYCNVEPSESNMRWAPEFMIDTLENPAAHTFTYTGLGKSLSENPANRYSFVCNALMHVCVGHHDPDRVNDIAILCAELTGYCKSLSAEWLGVLKALCCSSNNGTCGFNDLLCNVDVSDLSFHDSLATFVAILIARQCLLLEDLIRCAAIPSLLNAACSEQDSEPGARLTCRILLHLFKTPQLNPCQSDGNKPTVGIRSSCDRHLLAASQNRIVDGAVFAVLKAVFVLGDAELKGSGFTVTGGEELPEEEGGGSGGRRQGGRNISVETASLDVYAKYVLRSICQQEWVGERCLKSLCEDSNDLQDPVLSSAQAQRLMQLICYPHRLLDNEDGENPQRQRIKRILQNLDQWTMRQSSLDLRCFCGQTCKEEMNSLLENIAKATIEVFQQSAETGSSSGSTASNMPSSSKTKPVLSSLERSGVWLVAPLIAKLPTSVQGHVLKAAGEELEKGQHLGSSSRKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLYSQVHQIVNNWRDDQYLDDCKPKQLMHEALKLRLNLVGGMFDTVQRSTQQTTEWGLLLEIIISGTVDMQSNNLCYSPRLPVAVSSMPGSVASPEISCPSYFISLNPCPIFLCLQKELGERQSDSLEKVRQLLPLPKQTRDVITCEPQGSLIDTKGNKIAGFDSIFKKEQGLQVSTKQKISPWDLFEGLKPSAPLSWGWFGTVRVDRRVARGEEQQRLLLYHTHLRPRPRAYYLEPLPLPPEDEEPPAPTLLEPEKKAPDPPKTDKPGTAPPSTEERKKKSTKGKKRSQPATKTEDYGMAPGRSGPYGVAVPPDLLHHPASGSISHLSYRQGSIGLYTQNQPLPAGGPRVDPYRPVRLPMQKLPTRPTYPGVLPTTMTSVMGLDPSSYKTSVYRQQQPAVPQGQRLRQQLQAKIQSQGMLGQSSVHQMTPSSSYGLQTSQGYTPYVSHVGLQQHTGPAGTMVPPSYSSQPYQSTHPPTNPTLVDPTRHLQQRPSGYVHQQAPTYGHGLTTQRFSHQTLQQTPMIGTMAPLSAQGVQAGVRSASILPPAGKALGFRLGSKSPRRRRGIVCSQVVIKTNGGSVHSVPSRQQQQQTAPAGLQPQAQGQLPRLGMEPVNWVGDRVELDRGGRQGESSVLHVLFPPQFQRQGLQQTQQQQQTAALVRQLQQQLSNTQPQPNTNIFGRF
Length2184
PositionKinase
OrganismLoxodonta africana (African elephant)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Afrotheria> Proboscidea> Elephantidae> Loxodonta.
Aromaticity0.07
Grand average of hydropathy-0.401
Instability index53.63
Isoelectric point7.27
Molecular weight242163.83
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:Ensembl

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
chromatin binding	GO:0003682	IEA:Ensembl
protein C-terminus binding	GO:0008022	IEA:Ensembl
protein domain specific binding	GO:0019904	IEA:Ensembl
RNA polymerase II cis-regulatory region sequence-specific DNA binding	GO:0000978	IEA:Ensembl
thyroid hormone receptor binding	GO:0046966	IEA:Ensembl
transcription coactivator activity	GO:0003713	IEA:Ensembl

GO - Biological Process
axis elongation involved in somitogenesis	GO:0090245	IEA:Ensembl
canonical Wnt signaling pathway	GO:0060070	IEA:Ensembl
embryonic brain development	GO:1990403	IEA:Ensembl
embryonic neurocranium morphogenesis	GO:0048702	IEA:Ensembl
endoderm development	GO:0007492	IEA:Ensembl
heart development	GO:0007507	IEA:Ensembl
neural tube closure	GO:0001843	IEA:Ensembl
oligodendrocyte development	GO:0014003	IEA:Ensembl
positive regulation of transcription initiation from RNA polymerase II promoter	GO:0060261	IEA:Ensembl
post-anal tail morphogenesis	GO:0036342	IEA:Ensembl
Schwann cell development	GO:0014044	IEA:Ensembl
spinal cord development	GO:0021510	IEA:Ensembl
stem cell population maintenance	GO:0019827	IEA:Ensembl
Wnt signaling pathway, planar cell polarity pathway	GO:0060071	IEA:Ensembl









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP28244
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             8|     422.30|      54|      56|    1814|    1867|       1
---------------------------------------------------------------------------
 1593- 1641 (41.92/16.42)	......................................AS.PEIS...CPSYfislNPCP.IFLCLQKE...LG..ER.QSD....................SLEKVRqlLPL..........PK..................QTR
 1664- 1741 (45.14/18.33)	D.........S........IFK............K..EQG.LQVStkqKISP....WDLF.EGL.KPSAPLSWGwfGTvRVDrrvargeeqqrlllyhthlrP.RPRA..YYL..........EP.................LPLP
 1742- 1804 (36.66/13.30)	P.........EdeeppaptLLEpekkapdppktdK..PGT.APPS...TEER....KKKS.TKGKKRSQP......AT.KTE....................DYGMA....................................PGR
 1814- 1867 (98.51/49.99)	P.........D........LLH............H..PAS.GSIS...HLSY....RQGS.IGLYTQNQPLPAG..GP.RVD....................PYRPVR..LPM..........QK.................LPTR
 1871- 1940 (51.44/22.07)	P.........G........VL................PTTmTSVM...GLDP....SSYK.TSVYRQQQPAVPQ..GQ.RLR....................QQLQAK..IQS..........QGmlgqssvhqmtpsssygLQTS
 1941- 1993 (49.80/21.09)	QgytpyvshvG........LQQ............HtgPA..GTMV...PPSY.......S.SQPYQSTHP.PTN..PT.LVD....................PTR...................H.................LQQR
 2003- 2064 (52.95/22.97)	P.........T........YGH............G..LTT.QRFS...HQTL....QQTPmIGTMA...PLSAQ..GV.QAG....................VRSASI..LPPagkalgfrlgSK.................SPRR
 2071- 2113 (45.89/18.77)	S.........Q........VVI............K..TNG.GSVH...SVPS....RQ.......QQQQTAPAG.lQP.QAQ....................GQLP.R..LGM..........E......................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      82.26|      17|      20|    1047|    1063|       2
---------------------------------------------------------------------------
 1029- 1044 (26.04/15.46)	NP..AA.HTFTYTGLGKSL
 1047- 1063 (32.43/21.22)	NP..ANRYSFVCNALMHVC
 1068- 1086 (23.79/13.43)	DPdrVNDIAILCAELTGYC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     444.75|     142|     231|     219|     381|       4
---------------------------------------------------------------------------
  219-  381 (226.65/180.86)	TIGPLPHDVEV....AIRQWDYNEKLamfmfqDGMLDRHEFLTWVLECFEkIRPGEDELLKLLLPLLL..RYSGE...FVQSAYLSRRLAYFCTRRLalqldGVSSHSSHVMSAQSTS.TLPTTPAPQPPTTSTPSTPfSDLLMCPQ...HRPLVFGLscilqtILLCCPsaLVWH
  453-  607 (218.10/129.79)	TIGRVLHTLEVldshSFERSDFSNSL......DSLCNRIFGLGPSKDGHE.ISSDDDAVVSLLCEWAVscKRSGRhraMVVAKLLEKRQAEIEAERC.....GESEAADEKGSIASGSlSAPSAPIFQDVLLQFLDTQ.APMLTDPRsesERVEFFNL......VLLFCE..LIRH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      77.92|      24|      58|    1376|    1399|       5
---------------------------------------------------------------------------
 1376- 1399 (38.04/21.96)	SLLENIAKATIEVFQQSAETGSSS
 1437- 1460 (39.88/23.36)	SVQGHVLKAAGEELEKGQHLGSSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.38|      13|      16|     864|     879|       7
---------------------------------------------------------------------------
  864-  876 (24.86/22.11)	MSYHLPLVQHVQF
  881-  893 (22.52/ 8.68)	MEYSLSISGLIDF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.72|      15|      17|    1238|    1252|      11
---------------------------------------------------------------------------
 1238- 1252 (27.32/16.69)	GSGFTVTGGEELPEE
 1256- 1270 (27.39/16.76)	GSGGRRQGGRNISVE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.25|      16|      71|    1338|    1353|      12
---------------------------------------------------------------------------
 1318- 1341 (18.53/ 9.54)	RLmqlicypHRLLDNEDgENPQRQ
 1342- 1357 (29.72/20.47)	RI.......KRILQNLD.QWTMRQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.26|      15|      19|    2143|    2161|      20
---------------------------------------------------------------------------
 2143- 2158 (23.82/16.50)	QFQRQgLQQTQQQQQT
 2164- 2178 (28.44/ 8.57)	QLQQQ.LSNTQPQPNT
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28244 with Med12 domain of Kingdom Metazoa
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