<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28238

Description Mediator complex subunit 12
SequenceMAAFGILSYEHRPLKRPRLGPPDVYPQDPKQKEDELTALNVKQGFNNQPAVSGDEHGSAKNVNFNPAKISSNFSSIIAEKLRCNTLPDTGRRKPQVNQKDNFWLVTARSQSAINTWFTDLAGTKPLTQLAKKVPIFSKKEEVFGYLAKYTVPVMRAAWLIKMTCAYYAAITETKVKKRHVIDPFMEWTQIITKYLWEQLQKMAEYYRPGPAGSGSCASTIGPLPHDVEVAIRQWDYNEKLAMFMFQDGMLDRHEFLTWVLECFEKIRPGEDELLKLLLPLLLRYSGEFVQSAYLSRRLAYFCTRRLALQLDGVSSHSSHVMSAQSTSTLPTTPAPQPPTTSTPSTPFSDLLMCPQHRPLVFGLSCILQTILLCCPSALVWHYSLTDSRIKTGSPLDHLPIAPSNLPMPEGNSAFTQQVRAKLREIEQQIKERGQAVEVRWSFDKCQEATAGFTIGRVLHTLEVLDSHSFERSDFSNSLDSLCNRIFGLGPSKDGHEISSDDDAVVSLLCEWAVSCKRSGRHRAMVVAKLLEKRQAEIEAERCGESEAADEKGSIASGSLSAPSAPIFQDVLLQFLDTQAPMLTDPRSESERVEFFNLVLLFCELIRHDVFSHNMYTCTLISRGDLAFGAPGPRPPSPFDDPADDSERKETEGSSSSKLEDPGLSESMDIDPSSSVLFEDMEKPDFSLFSPTMPCEGKGSPSPEKPDVEKEVKSQPKEKIEGTLGVLYDQPRHVQYATHFPIPQEESCSHECNQRLVVLFGVGKQRDDARHAIKKITKDILKVLNRKGTAETDQLAPIVPLNPGDLTFLGGEDGQKRRRNRPEAFPTAEDIFAKFQHLSHYDQHQVTAQVSRNVLEQITSFALGMSYHLPLVQHVQFIFDLMEYSLSISGLIDFAIQLLNELSVVEAELLLKSSDLVGSYTTSLCLCIVAVLRHYHACLILNQDQMAQVFEGLCGVVKHGMNRSDGSSAERCILAYLYDLYTSCSHLKSKFGELFSDFCSKVKNTIYCNVEPSESNMRWAPEFMIDTLENPAAHTFTYTGLGKSLSENPANRYSFVCNALMHVCVGHHDPDRVNDIAILCAELTGYCKSLSAEWLGVLKALCCSSNNGTCGFNDLLCNVDVSDLSFHDSLATFVAILIARQCLLLEDLIRCAAIPSLLNAACSEQDSEPGARLTCRILLHLFKTPQLNPCQSDGNKPTVGIRSSCDRHLLAASQNRIVDGAVFAVLKAVFVLGDAELKGSGFTVEGTEELPEEEGGGSGGRRQGGRNISVETASLDVYAKYVLRSICQQEWVGERCLKSLCEDSNDLQDPVLSSAQAQRLMQLICYPHRLLDNEDGENPQRQRIKRILQNLDQWTMRHGELEKDKVLEDTAPKREMNSLLENIAKATIEVFQQSAETGSSSGSTASNMPSSSKTKPVLSSLERSGVWLVAPLIAKLPTSVQGHVLKAAGEELEKGQHLGSSSRKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLYSQVHQIVNNWRDDQYLDDCKPKQLMHEALKLRLNLVGGMFDTVQRSTQQTTEWGLLLEIIISGTVDMQSNNIPPAPTPGAWSTGIGVGSVASPEISCPSYFISLNPCPIFLCLQKELGERQSDSLEKVRQLLPLPKQTRDVITCEPQGSLIDTKGNKIAGFDSIFKKEACSIVSTKQKISPWDLFEGLKPSAPLSWGWFGTVRVDRRVARGEEQQRLLLYHTHLRPRPRAYYLEPLPLPPEDEEPPAPTLLEPEKKAPDPPKTDKPGTAPPSTEERKKKSTKGKKRSQPATKTEDYGMAPGRSGPYGVAVPPDLLHHPASGSISHLSYRQGSIGLYTQNQPLPAGGPRVDPYRPVRLPMQKLPTRPTYPGVLPTTMTSVMGLDPSSYKTSVYRQQQPAVPQGQRLRQQLQAKIQSQGMLGQSSVHQMTPSSSYGLQTSQGYTPYVSHVGLQQHTGPAGTMVPPSYSSQPYQSTHPPTNPTLVDPTRHLQQRPSGYVHQQAPTYGHGLTTQRFSHQTLQQTPMIGTMAPLSAQGVQAGVRSASILPEQQQQQQQQQQQQQQQQQQQQQQQYHIRQQQQQQILRSPRRRRGIVCSQVVIKTNGGSVHSHVNQKKKKQQTRRHRQQQQTAPPQPQPQSSPRFQRQGLQQTQQQQQTAALVRQLQQQLSNTQPQPNTNIFGRF
Length2183
PositionKinase
OrganismLoxodonta africana (African elephant)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Afrotheria> Proboscidea> Elephantidae> Loxodonta.
Aromaticity0.07
Grand average of hydropathy-0.473
Instability index56.27
Isoelectric point7.60
Molecular weight243132.37
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP28238
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     108.00|      17|      17|    2051|    2067|       1
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 1898- 1913 (20.75/ 6.47)	.QQQPAVPQGQRLRQQL
 2050- 2066 (33.46/15.39)	EQQQQQQQQQQQQQQQQ
 2067- 2082 (31.97/14.34)	QQQQQQQYH.IRQQQQQ
 2152- 2167 (21.81/ 7.21)	QQQQQTAALVRQLQQQ.
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.45|      16|      17|     639|     655|       3
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  639-  655 (23.97/23.92)	DDPAdDSERKETEGSSS
  659-  674 (29.48/22.90)	EDPG.LSESMDIDPSSS
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     169.75|      41|      58|    1360|    1400|       5
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 1360- 1400 (65.82/44.47)	LEKDKVLEDTAP..KREMNSLL...........ENIAKATIEVFQQSAETGSSS
 1420- 1461 (57.59/37.83)	LERSGVWL.VAPliAKLPTSVQ...........GHVLKAAGEELEKGQHLGSSS
 1514- 1558 (46.34/28.76)	WRDDQYLDDCKP..KQLMHEALklrlnlvggmfDTVQRST....QQTTEWG...
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     388.36|     124|     230|     219|     403|       6
---------------------------------------------------------------------------
  219-  355 (201.39/125.46)	TIGPLPHDVEV....AIRQWDYNEKLamfmfqDGMLDRHEFLTWVLECFEkIRPGEDELLKLLLPLLL..RYSGE...FVQSAYLSRRLAYFCTRRLalqldGVSSHSSHVMSAQSTS.TLPTTPAPQPPTTSTPSTPfSDLLMCPQ
  453-  586 (186.97/144.44)	TIGRVLHTLEVldshSFERSDFSNSL......DSLCNRIFGLGPSKDGHE.ISSDDDAVVSLLCEWAVscKRSGRhraMVVAKLLEKRQAEIEAERC.....GESEAADEKGSIASGSlSAPSAPIFQDVLLQFLDTQ.APMLTDPR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.57|      16|      17|     860|     876|       7
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  860-  876 (26.03/23.27)	FALgMSYHLPLVQHVQF
  878-  893 (28.55/19.26)	FDL.MEYSLSISGLIDF
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     476.40|     138|     148|     993|    1140|       8
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  929- 1079 (204.73/161.32)	AVLRHYhaCLILNQDQMAqVFEGLCGVVKHGM.NRSD.GSSAERCILAYLYDLYTSCSHLKSKFgeLFSDF..CSKVKNTI..YCNVEPSESNMRWAPEFMIDTLENPAAHTFTYTGlgkslsENPANRYSFVCNalMHVCVGHHdpDRVNDIAILC
 1080- 1223 (220.96/148.78)	AELTGY..CKSLSAEWLG.VLKALCCSSNNGTCGFNDLLCNVDVSDLSFHDSLATFVAILIARQclLLEDLirCAAIPSLLnaACSEQDSEPGARLTCRILLHLFKTPQLNPCQSDG......NKPTVGIRSSCD..RHLLAASQ..NRIVDGAVFA
 1234- 1288 (50.71/24.30)	AELKG....SGFTVE..G.T.EELPEEEGGGSGGRRQGGRNISVETASL.DVYAKYVLRSICQQ.............................................................................................
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     290.40|      54|     124|    1802|    1855|       9
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 1751- 1778 (26.79/ 6.54)	..........................................................AP....T..LLEPEKKAPDPPKTDKPGTAPPSTE
 1779- 1830 (66.13/27.02)	ERKKKSTK.................................GKKRSQP.atktedygMAP....G..RSGPYGVAVPPDLLHHPASGSISHL
 1831- 1886 (71.06/29.59)	SYRQGSIGLYT....................Q...NQPLPAGGPRVDPyrpvrlpmqKLP....T..RPTYPGV.LPTTM......TSVMGL
 1890- 1952 (54.99/21.22)	SYK...TSVYRqqqpavpqgqrlrqqlqakiQ...SQGM.LGQSSVHQ.........MTP........SSSYGLQTSQG..YTP...YVSHV
 1953- 1984 (39.47/13.14)	GLQQ....................................HTGP.AGT.........MVP....PsySSQPYQSTHPPT...NPT.......
 2006- 2049 (31.96/ 9.23)	TY..GH.GLTT....................QrfsHQTLQQ.TPMIGT.........MAPlsaqG.vQAGVRSASILP..............
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---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.10|      16|      19|    1653|    1670|      10
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 1653- 1670 (19.33/19.25)	SLIDTKgNKIAGFDsIFK
 1675- 1690 (29.77/17.40)	SIVSTK.QKISPWD.LFE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      97.05|      29|     125|    1481|    1510|      12
---------------------------------------------------------------------------
 1463- 1488 (36.89/20.56)	KERDRQKQKSMSLLSQQ........pFLSLVLTC
 1490- 1510 (27.14/11.89)	KGQDEQREGLLTSLYSQVHQI.............
 1619- 1648 (33.03/13.26)	KELGERQSDSLE....KVRQLlplpkQTRDVITC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.36|      19|      70|     614|     635|      13
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  614-  635 (33.21/22.87)	MYTCTLISRGDlafGAPGPRPP
  687-  705 (38.15/18.90)	LFSPTMPCEGK...GSPSPEKP
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.89|      16|      23|    2114|    2129|      14
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 2114- 2129 (28.05/14.32)	QKKKKQQTRRHRQQQQ
 2134- 2149 (29.84/15.78)	QPQPQSSPRFQRQGLQ
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---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.42|      23|      23|    1296|    1318|      15
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 1296- 1318 (37.53/20.11)	LKSLCEDSNDLQDPVLSSAQAQR
 1320- 1342 (41.89/23.33)	MQLICYPHRLLDNEDGENPQRQR
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28238 with Med12 domain of Kingdom Metazoa
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