<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28234

Description Uncharacterized protein
SequenceMAAFGLLSYEQRPLKRPRLGPPDVYPQDPKQKEDELTAVNVKQGFNNQPAFTGDEHGSARNIVINPSKIGAYFSSILAEKLKLNTFQDTGKKKPQVNAKDNYWLVTARSQSVIHSWFSDLAGNKPLAILAKKVPILSKKEDVFAYLAKYSVPMVRATWLIKMTCAYYSAISEAKIKKRQATDPNLEWTQISTRYLREQLAKISDFYHMASSTGDGPAPVPPDVEQAMRQWEYNEKLAFHMFQEGMLEKHEYLTWILDVLEKIRPMDDDLLKLLLPLMLQYSDEFVQSAYLSRRLAYFCARRLSLLLSDSPNLLTAHSPHVMIGPNTSSIGAPSPGPPGPGMSPVQLAFSDFLSCAQHGPLVYGLSCMLQTVTLCCPSALVWNYSTNENKSANPGSPLDLLQVAPSSLPMPGGNTAFNQQVRARIYEVERQIKQRGRAVEVRWSFDKCQESTAGVTISRVLHTLEVLDRHCFDRTDSSNSMETLYHKIFWPNQNKDNQEVAPNDEAVVTLLCEWAVSCKRSGKHRAMAVAKLLEKRQAEIEAERCGESEVLDEKESISSASLAGSSLPVFQNVLLRFLDTQAPSLSDPNSECEKVEFVNLVLLFCEFIRHDVFSHDAYMCTLISRGDLSVTASTRPRSPAGENVDEHYSKDHDAKMEIFSPMPGESCENANPALGRRMSVNGEKLMKREKPRELIFPSNYGLLRHLQYATHFPVPLDESSSHECNQRTILLYGVGKEREEARHQLKKITKDILKTLNKKSTAETGGVDEGQKARKNKQEAFPTLETVFTKLQLLSYFDQHQVTSQISNNVLEQITSFASGTSYHLPLAHHVQLIFDLMEPALNINGLIDFAIQLLNELSVVEAELLLKSSSLAGSYTTGLCVCIVAVLRRYHSCLILNPDQTAQVFEGLCGVVKHVVNPSECSSPERCILAYLYDLYVSCSHLRSKFGDLFSSACSKVKQTIYNNVMPANSNLRWDPDFMMDFIANPSARSINYSMLGKILSDNAASRYSFVCNTLMNVCMGHQDAGRINDIANFSSELTACCTVLSSEWLGVLKALCCSSNHVWGFNDVLCTVDVSDLSFHDSLATFIAILIARQCFSLEDVVQHVALPSLLAAACGDADAEPGARMTCRLLLHLFRAPQACLLPQASGKPFPGIRSSCDRHLLAAAHNSIEVGAVFAVLKAIMMLGDAKIGNNNVSSLKNDDFTVRGLRRDGNADDIWTASQNSKSCGKSISIETANLREYARHVLRTICQQEWVGEHCLKEPERLCTDKELILDPVLSNIQAQKLLQLICYPHGIKECTEGDNLQRQHIKRILQNLEQWTLRQSWLELQLMIKQCLKDPGSGSVAEMNNLLDNIAKATIEVFQQSADLNNNSSSSGMGLFTPNSIGSTDASSTRQNGIKTFLSSSERRGVWLVAPLIARLPTSVQGRVLKAAGEELEKGQHLGSSSKKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLQNQVNQILSNWREERYQDDIKARQMMHEALQLRLNLVGGMFDTVQRSTQWTTDWALLLLQIITSGTVDMHTNNELFTTVLDMLGVLINGTLASDLSTASPGGSEENKRAYMNLVKKLKKELGDKRSESIDKVRQLLPLPKQTCDVITCEPMGSLIDTKGNKIAGFDSIDKKQARGLQVSAKQKVSPWDLFEGQKNPAPLSWAWFGTVRVDRKVIKYEEQHHLLLYHTHPMPKPRSYYLEPLPLPPEEEEEEPTSPVSQEPDRKSAELSDQGKTAMDEEKKTKGRKRKTKSSSRVDEYPQSNMYRVPPNYSPISSQMMHHPQSTLWGYNLMGQPQQPSFFLQNQSLTPGGSRLDPAGAFVPTNTKQALSNMLQRRSGAMLQPPSLHAITSQQQLIQMKLLQQQQQQRLLRQAQTRPFQQVCPAPDFQGQPGDQTALFAAQARPSPQLPQYPGLQLAQTMPQGYTMYGTQMPLQQAPQQQAGSVVLSPSYNSRTYPAAHSNPALMERLRQMQQPPSGYVQQQATPYLQSLTGSQRLNHQTLQQSPLVSGGVDAVLTSAHPNLPSVPLPQDPMRPRQAQVRQQQRLLQVWARAMRAPQQPPQPQQSSQPQGQTLGLQAMQPQQPLFPRQGLQQTQQQQQTAALVRQLQKQLSSNQPQQGVTPYGHPSHF
Length2156
PositionKinase
OrganismLoxodonta africana (African elephant)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Afrotheria> Proboscidea> Elephantidae> Loxodonta.
Aromaticity0.07
Grand average of hydropathy-0.413
Instability index56.87
Isoelectric point8.27
Molecular weight240851.95
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP28234
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     167.31|      25|      25|    1894|    1918|       1
---------------------------------------------------------------------------
 1894- 1910 (24.57/ 7.65)	............QQR....LLRQA.Q.....TRPFQ..QVC
 1911- 1937 (34.73/13.89)	PAPDF.QGQ.pgDQT....ALFAA.Q.....ARPSP..QLP
 2011- 2036 (24.38/ 7.54)	ATPYL.QSL.tgSQR....LNHQTlQ.....QSPL....VS
 2059- 2087 (28.59/10.12)	PMRPR.QAQvrqQQR....LL.QV.W.....ARAMRapQQP
 2088- 2113 (31.80/12.09)	PQPQQ.SSQ.pqGQT....LGLQA.M......QPQQ..PLF
 2114- 2148 (23.25/ 6.84)	PRQGLqQTQ...QQQqtaaLVRQL.QkqlssNQPQQ..GVT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     178.69|      47|     152|     875|     921|       2
---------------------------------------------------------------------------
  848-  892 (50.30/24.38)	......DFAIQLLNELSVVEAELLLKSSSlagsYTTGL..CVCIVAV..LRR..............YHS
  893-  938 (46.39/21.97)	CLILNPDQTAQVFEGLCGVVKHVVNPSEC.......................sspercilaylydlYVS
  939-  961 (22.72/ 7.37)	CSHLRS.KFGDLFSSACSKVKQTI.............................................
 1042- 1083 (59.28/29.93)	CTVLSSEWLG.VLKALCC........SSN....HVWGFndVLCTVDVsdLSF..............HDS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     186.40|      68|     152|    1186|    1269|       4
---------------------------------------------------------------------------
 1192- 1269 (101.37/91.99)	GNNNVSSLKN..DDF...TVRGLRRDGnadDIwtaSQNSKSCG......KSI.SIETANLREYArhvLRT.ICQQEWVGEHcLKEP..ERLCT
 1342- 1424 (85.03/43.31)	GSGSVAEMNNllDNIakaTIEVFQQSA...DL...NNNSSSSGmglftpNSIgSTDASSTRQNG...IKTfLSSSERRGVW.LVAPliARLPT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     105.71|      34|     155|      45|      88|       7
---------------------------------------------------------------------------
   45-   88 (45.70/57.04)	FNNQPAFTGDehGSArniVINPSKIGA.....YfssilAEKLKLNTFQD
  205-  243 (60.01/40.58)	FYHMASSTGD..GPA...PVPPDVEQAmrqweY.....NEKLAFHMFQE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     170.95|      52|     192|    1624|    1679|      11
---------------------------------------------------------------------------
 1624- 1679 (87.31/51.24)	QLLPLPKQTCDVITCE...PMGSLIDTKGnkiaGFDSIDKKQARG..LQVSAKQKVSPWDL
 1818- 1874 (83.65/41.93)	NLMGQPQQPSFFLQNQsltPGGSRLDPAG....AFVPTNTKQALSnmLQRRSGAMLQPPSL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28234 with Med12 domain of Kingdom Metazoa
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