<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28233

Description Mediator of RNA polymerase II transcription subunit 15
SequenceEDAMRKAGVAHSKSSKDMESHVFLKAKTRDEYLSLVARLIIHFRDIHNKKSQASVGDPMNALQNLTGTPAAGATGISMAARGPGQSMGGMGSLGAMGQPPPGTSGITPHGMAVVSTATPQITLEITGYNSEDKIRFFSQDSFQPRQLSAPQPCLQAGHSLRWQKLSAYDRIQSYHFYIDIMQKLLRDVDRTNAFIKINRKASLNNIQRIIVIQCSQLQLQQLHHQNQQQVTRPLHPPASPGLSLPVPPPQLPPSCCATAHAGFLRARPAQALQAPPVAQNQPLQLPPQSVPSQAPALSGQMLYTQQQLKLVRAPMVVQQPQVQPQVQPQVQQQTTVQTPQATQMVASGVQVAEDNHTTLGGGSSEPGQLWLRAPQSMPPLPSVSQPSAQLTADSTSGPAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLDKLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLDILTDPSKRCPLKTLQKCEIALEKLKNDMAVPTPPPPPVPPTKQQYLCQPLLDAVLANIRSPVFNHSLYRTFMPPMAAIHGPPITVPAVCTRKRKFEEDERQSIPNVLQGEVARLDSKFLVNLDPSHCSNNGTVHLICKLDDKDLPSVPPLELSVPADYPAQSPLWVDQQWQYDANPFLQSVHRCMTSRLLQLPDKHSVTALLNTWAQSVHQACLSDA
Length713
PositionTail
OrganismLoxodonta africana (African elephant)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Afrotheria> Proboscidea> Elephantidae> Loxodonta.
Aromaticity0.04
Grand average of hydropathy-0.442
Instability index69.63
Isoelectric point9.22
Molecular weight77916.29
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364148

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP28233
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     163.63|      35|      36|     378|     412|       1
---------------------------------------------------------------------------
  278-  307 (35.59/ 8.92)	AQ.NQP.LQLPPQSV..................PSQAPALSGQMLYTQQQ....
  328-  380 (39.55/10.71)	PQVQQQTTVQTPQATqmvasgvqvaednhttlgGGSSEPGQLWLRAPQSM.PPL
  381-  413 (52.23/16.44)	PSVSQPSAQLTADST..................SGPAPSPSSFLPSPSPQ.P..
  508-  537 (36.26/ 9.22)	KTLQKCEIALEKLKN..................DMAVPTPP...PPP...vPPT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      83.16|      23|     144|      92|     124|       2
---------------------------------------------------------------------------
   67-   89 (40.63/25.82)	GTPAAGATGISMAARGPGQSMGG
   97-  119 (42.53/25.70)	GQPPPGTSGITPHGMAVVSTATP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      65.50|      14|      36|     458|     471|       3
---------------------------------------------------------------------------
  458-  471 (24.93/14.53)	LDK....LKQLSKYIEPL
  478-  494 (16.10/ 6.90)	IDKnedrKKDLSK.MKSL
  495-  507 (24.47/14.14)	LDI....LTDPSKRC.PL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     138.79|      32|     144|     423|     456|       4
---------------------------------------------------------------------------
  137-  161 (34.61/13.00)	...FSQDSFQPRQLS.APQPCLQA.GHSLR.....
  240-  270 (54.37/25.67)	P.GLSLPVPPP.QLP..PSCCATAhAGFLRARPAQ
  423-  456 (49.81/30.42)	PqNFSVPSPGPLNTPvNPSSVMSP.AGSSQAEEQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.50|      14|      15|     177|     190|      10
---------------------------------------------------------------------------
  177-  190 (24.26/17.67)	YIDIMQKL.LRDVDR
  194-  208 (19.23/12.64)	FIKINRKAsLNNIQR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28233 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) APMVVQQPQVQPQVQPQVQQQTTVQTPQATQMVASGVQVAEDNHTTLGGGSSEPGQLWLRAPQSMPPLPSVSQPSAQLTADSTSGPAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLDKLKQ
2) RPAQALQAPPVAQNQPLQLPPQSVPSQAPALS
313
267
463
298










Molecular Recognition Features






MoRF SequenceStartStop




NANANA