<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28232

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMDLAYVCEWEKWPRSTLCPSVPLACAWSCRNLIAFTTDLRNDDQDLTRMIHILDTEHPWEVHSIDSEHREAITCLEWDQSGSRLLSADADGQIKCWGMADHLANSWESPVGSLVEGDPIVALSWLHNGVKLALHVEKSGASSFGEKFSRVKFSPSLTLFGGKPMEGWIAVTVSGLVTVSLLKPSGQVLTSTESLCRLRGRVALADIAFTGGGNIVVATADGSSASPVQFYKVCVSVVSEKCRIDTEILPSLFMRCTTDLNRKDRFPAITHLKFLARDMSEQHLTNLITASSIVPSFLSCPRFCRALVSVVSLFAPVLVSVGDKQPMILKWRILSATNDLDRVSAVALPKLPISLTNTDLKVASDTQFYPGLGLALAFHDGSVHIVHRLSLQTMAVFYSSAAPRSVDEPAIKRPRTTGPAVHFKAMQLSWTSLALVGIDNHGKLNMLRISPSLGHTLEVSLALRHLLFLLEYCMVTGYDWWDILLHVQPGMVQSLVEKLHEEYTRQSAALQQVVLSTRILAMKASLCKLSPNTVTRVCDYHAKLFLIAISSTLRSLLRPHFLNTPDKSPGDRLTEICSKITDVDIDKVMINLKTEEFVLDTNTLQALQQLLQWVGDFVLYLLASLPNQGSPLRPGHSFLRDGTSLGILRELMVVIRIWGLLKPSCLPVYTATSDTQDSMSLLFRLLTKLWICCRDEGPTSEPDEALVDECCLLPSQLLIPSLDWLPVSDGLISRLQPKQPLRLHFRAPTLPGSAAASQLDAPRPARAPGQPKIDHLRRLHLGAYPTEECKACTRCGCVTMLKSPNKTTAVKQWEQRWIKNCLCGGLWRRMRLAYP
Length834
PositionTail
OrganismLoxodonta africana (African elephant)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Afrotheria> Proboscidea> Elephantidae> Loxodonta.
Aromaticity0.07
Grand average of hydropathy0.058
Instability index47.08
Isoelectric point8.28
Molecular weight92473.46
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:Ensembl

GO - Biological Function
thyroid hormone receptor binding	GO:0046966	IEA:Ensembl
transcription coactivator activity	GO:0003713	IEA:Ensembl

GO - Biological Process
positive regulation of transcription initiation from RNA polymerase II promoter	GO:0060261	IEA:Ensembl









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP28232
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     153.80|      58|     240|     302|     365|       1
---------------------------------------------------------------------------
  302-  340 (54.76/30.79)	.....................................................................................................................................................................................................FCRALVSVV.SLFA.......PVLVSVGDKQ.PMILKWRILSATNDLD
  347-  365 (10.04/ 6.74)	LPKLPISLTNTDLKVASDT..................................................................................................................................................................................................................................
  544-  583 (47.28/25.30)	...................qfypglglalafhdgsvhivhrlslqtmavfyssaaprsvdepaikrprttgpavhfkamqlswtslalvgidnhgklnmlrispslghtlevslalrhllflleycmvtgydwwdillhvqpgmvqslveklheeytrqsaalqqvvlstrilamkaslcklspntvtrvcdyhaklFLIAISSTLrSLLR.......PHFLNTPDKS.PGDRLTEICSKITDVD
  584-  685 (41.72/18.29)	IDKVMINLKTEEFVLDTNT.......................................................................................................................................lqalqqllqwvgdfvlyllaslpnqgsplrpghsflrdgtslgILRELMVVI.RIWGllkpsclPVYTATSDTQdSMSLLFRLL.......
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     224.91|      74|     351|     369|     450|       2
---------------------------------------------------------------------------
  369-  450 (114.82/95.35)	PGLGLaLAFHDGsvhIVHRLS.LQTMAVFY......SSAAPRSVDEPaikRP.RTTG.PAV.HFKAMQL.SWTSLALVGIDNHGKLNMLRiSP
  719-  803 (110.09/69.15)	PSLDW.LPVSDG...LISRLQpKQPLRLHFraptlpGSAAASQLDAP...RPaRAPGqPKIdHLRRLHLgAYPTEECKACTRCGCVTMLK.SP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     102.31|      27|     135|      10|      36|       3
---------------------------------------------------------------------------
   10-   36 (53.26/28.43)	EKWPRSTLCPSVPLACAWSCRNLIAFT
  145-  171 (49.05/25.64)	EKFSRVKFSPSLTLFGGKPMEGWIAVT
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28232 with Med16 domain of Kingdom Metazoa
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