<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28228

Description Cyclin dependent kinase 19
SequenceLLRELKHPNVIALQKVFLSHSDRKVWLLFDYAEHDLWHIIKFHRASKANKKPMQLPRSMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPFHHDQLDRIFSVMGFPADKDWEDIRKMPEYPTLQKDFRRTTYANSSLIKYMEKHKVKPDSKVFLLLQRLLTMDPTKRITSEQALQDPYFQEDPLPTLDVFAGCQIPYPKREFLNEDEPEEKGEKKNQQQQQNQHQQPTAPPQQAAAPPPAPPQQQNSTQTNGLQHSQDAGLNQVPPNKKPRLGPSGANSGGPVMPSDYQHSSSRLNYQSSVQGSSQSQSTLGYSSSAQQSAQYHSSHQTHRY
Length420
PositionKinase
OrganismLoxodonta africana (African elephant)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Afrotheria> Proboscidea> Elephantidae> Loxodonta.
Aromaticity0.09
Grand average of hydropathy-0.709
Instability index57.93
Isoelectric point8.96
Molecular weight48091.97
Publications









Function






Annotated function


GO - Cellular Component
GO - Biological Function
ATP binding	GO:0005524	IEA:InterPro
protein kinase activity	GO:0004672	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP28228
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     115.45|      36|      41|     284|     322|       1
---------------------------------------------------------------------------
  284-  322 (59.38/36.93)	PYPKREflnEDEPEEKGEKKNQQQQQNQ...HQQPTAPPQQA
  327-  365 (56.07/27.98)	PAPPQQ...QNSTQTNGLQHSQDAGLNQvppNKKPRLGPSGA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     119.22|      36|      40|     119|     158|       2
---------------------------------------------------------------------------
   83-  109 (31.61/20.87)	.........DLKPANILVMGEGPE.....RGRVKIADMgFA
  112-  151 (59.27/57.12)	FNSPLKPLADLDPVVVTFWYRAPELllgaRHYTKAIDI.WA
  152-  173 (28.35/16.47)	IGCIFAELLTSEPI...FHCRQEDI................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.18|      15|      17|     378|     394|       3
---------------------------------------------------------------------------
  380-  394 (27.55/18.61)	SSRLNYQSSVQGSSQ
  396-  410 (26.64/10.56)	QSTLGYSSSAQQSAQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.18|      27|      40|     209|     241|       4
---------------------------------------------------------------------------
  209-  241 (37.01/33.13)	PTlqkdfRRTTYANSSLIKYMEKHKVkPDSKVF
  252-  278 (48.17/26.30)	PT.....KRITSEQALQDPYFQEDPL.PTLDVF
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28228 with CDK8 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) YPKREFLNEDEPEEKGEKKNQQQQQNQHQQPTAPPQQAAAPPPAPPQQQNSTQTNGLQHSQDAGLNQVPPNKKPRLGPSGANSGGPVMPSDYQHSSSRLNYQSSVQGSSQSQSTLGYSSSAQQSAQYHSSHQTHRY
285
420










Molecular Recognition Features






MoRF SequenceStartStop




1) TLGYS
398
402