<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28227

Description Mediator of RNA polymerase II transcription subunit 15
SequenceQQQQQQQQHLILHHQNQQQIQQQQQQQLQRMAQLQLQQQQQQQALQAPPMQQSPMQQPQPPSAQALPQQLQQMHHPQHHQPPPPPPQQPPVAQNQPLQLPPQSVPSQAPALSGQMLYTQQQLKLVRAPMVVQQPQVQPQVQPQVQQQTTVQTPQATQMVASGVQMITAAMAQGGMQVRARFPPSTAVSAAPPGALPTGGQPPAQVFTISTLHPCXXXXXXXXXXPPQSMPPLPSVSQPSAQLTADSTSVGQSSGPAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLDKLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLDILTDPSKRCPLKTLQKCEIALEKLKNDMAVPTPPPPPVPPTKQQYLCQPLLDAVLANIRSPVFNHSLYRTFMPPMAAIHGPPITVPAVCTRKRKFEEDERQSIPNVLQGEVARLDSKFLVNLDPSHCSNNGTVHLICKLDDKDLPSVPPLELSVPADYPAQSPLWVDQQWQYDANPFLQSVHRCMTSRLLQLPDKHSVTALLNTWAQSVHQACLSDA
Length570
PositionTail
OrganismLoxodonta africana (African elephant)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Afrotheria> Proboscidea> Elephantidae> Loxodonta.
Aromaticity0.03
Grand average of hydropathy-0.613
Instability index88.41
Isoelectric point8.99
Molecular weight61645.72
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364148

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP28227
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.76|      17|      17|      17|      33|       1
---------------------------------------------------------------------------
   17-   33 (33.63/ 8.32)	QQQIQQQQQQQLQRMAQ
   86-  102 (31.13/ 7.10)	PQQPPVAQNQPLQLPPQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     169.55|      33|      34|     225|     257|       2
---------------------------------------------------------------------------
   48-   72 (39.71/ 8.07)	...PPMQQS.PMQQPQP.PSAQ......ALPQQLQQ
  125-  151 (38.03/ 7.35)	VR.APMV.......VQQ.PQVQPQVQPQVQQQTTVQ
  225-  255 (50.50/12.69)	...PPQSMP.PLPSVSQ.PSAQLTADSTSVGQSSGP
  256-  290 (41.31/ 8.75)	APsPSSFLPsPSPQPSQsPVTARTPQNFSV.PSPGP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.40|      23|      28|     345|     371|       5
---------------------------------------------------------------------------
  336-  363 (35.23/18.67)	DKNEdrkkdLSKMKSLLDILTDPSKRCP
  368-  392 (39.17/13.94)	QKCE...iaLEKLKNDMAVPTPPPPPVP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.02|      22|     232|     181|     205|       6
---------------------------------------------------------------------------
  153-  181 (29.03/10.41)	PQATQMVASGVqmitAAMAQGG...MQVrarF
  182-  206 (36.00/22.14)	PPSTAVSAAPP....GALPTGGqppAQV...F
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.69|      17|     191|     103|     124|       9
---------------------------------------------------------------------------
  103-  121 (27.11/20.75)	SVPSQAPALSGqmLYTQQQ
  506-  522 (34.58/12.84)	SVPADYPAQSP..LWVDQQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28227 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) APMVVQQPQVQPQVQPQVQQQTTVQTPQATQMVASGVQMITAAMAQGGMQVRARFPPSTAVSAAPPGALPTGGQPPAQVFTISTLH
2) CXXXXXXXXXXPPQSMPPLPSVSQPSAQLTADSTSVGQSSGPAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLDKLKQ
3) QQQQQQQQHLILHHQNQQQIQQQQQQQLQRMAQLQLQQQQQQQALQAPPMQQSPMQQPQPPSAQALPQQLQQMHHPQHHQPPPPPPQQPPVAQNQPLQLPPQSVPSQAPALSG
127
214
1
212
320
113










Molecular Recognition Features






MoRF SequenceStartStop




NANANA