<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28226

Description Mediator complex subunit 25
SequenceMVPGSEGPARAGGLVADVVFVIEGTANLGPYFEGLRKHYLLPAIDFLTWWSSSETAFGGDYGGTQYSLVVFNTVDCAPESYVQCHAPTSSAYEFVTWLDGIKFMGGGGESCSLIAEGLSTALQLFDDFKKMREQIGQTHRVCLLICNSPPYLLPAVESTTYSGYTTENLVQKMFRRGIHFSIVSPRKLPALRLLFEKAAPPALLEPLQPLTDVSQDPRHMVLVRGLVLPVGGSSAPGPLQPKQPVPLPPAPTSGAALSAAPQQPLPPVPQQYQVPGNLSAAQVAAQNAVEAAKSQKAGLGPRFSPINPLQQAAPGVGPPFSQPTAPPLPPGPPGAPKPPPVSQPSLVSSVAPGSGLAPPAQPGASSMAGSVAPGGVSGPSPAQLGTPALGGQQSVSNKLLAWSGVLEWQEKPKPASVDASTKLTRSLPCQVYVNHGENLKTDQWPQKLIMQLIPQQLLTTLGPLFRNSRMVQFYFTNKDLESLKGLYRIMGNGFAGCVHFPHTAPCEVRVLMLLYSSKKKIFMGLIPYDQSGFVNGIRQVITNHKQVQQQKLEQQRGMGGQQAPPGLGPILEDQARPTQNLLQLRPPQPQPPGAVGASGAAGQPQPQGAAQAPSGAPQGPPGAGTGPPPPGPILRPQNPGANPQLRSLLLNPPPPAPDTGGPLSWERQSGLLSGVGVALCQVSGQTVPLSSSPTGFCRDPLKYWEMQSLPHCPPGQMLLSGGPRGPVPQPGLQPSVMEDDILMDLI
Length746
PositionUnknown
OrganismLoxodonta africana (African elephant)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Afrotheria> Proboscidea> Elephantidae> Loxodonta.
Aromaticity0.06
Grand average of hydropathy-0.189
Instability index55.70
Isoelectric point8.74
Molecular weight78417.12
Publications









Function






Annotated function


GO - Cellular Component
nucleoplasm	GO:0005654	IEA:Ensembl

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP28226
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.38|      16|      16|     608|     623|       1
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  603-  618 (31.30/ 7.87)	QPQPQGAAQAPSGAPQ
  619-  634 (31.08/ 7.75)	GPPGAGTGPPPPGPIL
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     318.81|      60|      60|     217|     276|       2
---------------------------------------------------------------------------
  217-  273 (102.01/32.89)	...........PRHM......VLVRGLVLPVGGSSAP.G....PL.QPK.QPV....................PL.PPAPTSGAALSAAPQQPLPPVPQQYQ
  274-  327 (42.30/ 8.45)	VPG............nlsaaqVAAQNAV.EAAKSQKA.G.....L.GPRfSPI...................nPLqQAAPGVGPPFS....QPTAP.P....
  362-  433 (54.96/13.64)	.PG...........A......SSMAGSVAP.GGVSGP.S....PA.QLG.TPAlggqqsvsnkllawsgvlewQE.KPKPASVDA.STKLTRSLP..CQVYV
  434-  488 (44.72/ 9.44)	NHGenlktdqwPQKL......IM...QLIPQQLLTTL.G....PLfRNS.RMV....................QF.YFT...........NKDLESLKGLYR
  672-  735 (74.82/21.76)	LSG.......vGVAL......CQVSGQTVPL..SSSPtGfcrdPL.KYW.EMQ....................SL.PHCPPGQMLLSGGPRGPVPQPGLQPS
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.50|      11|     111|      39|      49|       3
---------------------------------------------------------------------------
   39-   49 (22.67/12.82)	YLLPAIDFLTW
  151-  161 (20.82/11.23)	YLLPAVESTTY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     100.82|      28|      65|     575|     602|       4
---------------------------------------------------------------------------
  575-  602 (49.45/17.96)	ARPTQNLLQLRPPQPQP..PGAVGASGAAG
  641-  670 (51.37/19.00)	ANPQLRSLLLNPPPPAPdtGGPLSWERQSG
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.15|      12|      43|      57|      69|       8
---------------------------------------------------------------------------
   57-   69 (19.50/15.43)	FGGDyGGTQYSLV
  103-  114 (24.65/13.81)	FMGG.GGESCSLI
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     187.64|      42|     358|     171|     212|       9
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  171-  212 (73.36/41.66)	QKMFRRGIHFSI.....VSPRKLPALRLLFEKAAPPALLEPLQPLTD
  494-  529 (55.00/29.15)	...FAGCVHFPH.....TAPCEVRVLMLLY..SSKKKIFMGLIPY.D
  530-  573 (59.28/32.07)	QSGFVNGIRQVItnhkqVQQQKLEQQRGMGGQQAPPG.LGPI..LED
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28226 with Med25 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) HKQVQQQKLEQQRGMGGQQAPPGLGPILEDQARPTQNLLQLRPPQPQPPGAVGASGAAGQPQPQGAAQAPSGAPQGPPGAGTGPPPPGPILRPQNPGANPQLRSLLLNPPPPAPDTGGPLSWERQ
2) SSAPGPLQPKQPVPLPPAPTSGAALSAAPQQPLPPVPQQYQVPGNLSAAQVAAQNAVEAAKSQKAGLGPRFSPINPLQQAAPGVGPPFSQPTAPPLPPGPPGAPKPPPVSQPSLVSSVAPGSGLAPPAQPGASSMAGSVAPGGVSGPSPAQLGTPALG
544
233
668
390










Molecular Recognition Features






MoRF SequenceStartStop




NANANA