<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28224

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMDVSGQETDWRSAAFRQKLVSQIEDAMRKAGVAHSKSSKDMESHVFLKAKTRDEYLSLVARLIIHFRDIHSSPGFSGVNDPMNALQNLTGTPAAGATGISMAARGPGQSMGGMGSLGAMGQPPPGTSGITPHGMAVVSTATPQTQLQLQQVALQQQQQQFQQQQAALQQQQQQFQAQQSAMQQQFQAAVQQQQQQLQQQQQQQQQQHLILHHQNQQQQQQQQQLQRMAQLQLQQQQQQQALQAPPMQQSPMQQPQPPSAQALPQQLQQMHHPQHHQPPPPPPQQPPVAQNQPLQLPPQSVPSQAPALSGQMLYTQQQLKLVRAPMVVQQPQVQPQVQPQVQQQTTVQTPQATQMVASGVQMITAAMAQGGMQVRARFPPSTAVSAAPPGALPTGGQPPAQSAQAVWTVLTKQAPGGPLHPKSMPPLPSVSQPSAQLTADSTSGPAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLDKLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLDILTDPSKRCPLKTLQKCEIALEKLKNDMAVPTPPPPPVPPTKQQYLCQPLLDAVLANIRSPVFNHSLYRTFMPPMAAIHGPPITVPAVCTRKRKFEEDERQSIPNVLQGEVARLDSKFLVNLDPSHCSNNGTVHLICKLDDKDLPSVPPLELSVPADYPAQSPLWVDQQWQYDANPFLQSVHRCMTSRLLQLPDKHSVTALLNTWAQSVHQACLSDA
Length759
PositionTail
OrganismLoxodonta africana (African elephant)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Afrotheria> Proboscidea> Elephantidae> Loxodonta.
Aromaticity0.04
Grand average of hydropathy-0.613
Instability index80.11
Isoelectric point9.26
Molecular weight83089.55
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364148

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
nucleoplasm	GO:0005654	IEA:Ensembl

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP28224
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     152.81|      31|      33|     143|     173|       1
---------------------------------------------------------------------------
  143-  173 (61.92/16.29)	QTQLQLQQV.A.LQQQQQQF...QQQQAALQQ...QQQQ
  219-  250 (42.35/ 8.64)	QQQQQLQRM.AqLQLQQQQ.....QQQA.LQAppmQQSP
  251-  285 (48.53/11.06)	MQQPQPPSAqA.LPQQLQQMhhpQHHQPPPPP...PQQP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     185.17|      57|      96|     286|     349|       3
---------------------------------------------------------------------------
  321-  362 (67.92/21.66)	V...RAPMVVQQPQVQPQV....QPQVQ...QQTTVQT...........................................PQA..TQMVASGVQMI..
  363-  407 (62.78/14.25)	....TAAM....AQGGMQV....RARF...........P..........................PstaVSAAPPGALP..T...GGQPPAQSAQAVWT
  408-  500 (54.48/11.98)	VltkQAPGGPLHPKSMPPLpsvsQPSAQltaDSTSGPAPspssflpspspqpsqspvtartpqnfS...VPSPGPLNTPvnPSSvMS..PAGSSQA.EE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      82.71|      23|      27|      77|      99|       4
---------------------------------------------------------------------------
   77-   99 (41.62/19.55)	GVNDPMNALQNLT..GTPAAGATGI
  105-  129 (41.09/19.21)	GPGQSMGGMGSLGamGQPPPGTSGI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.00|      14|      28|     504|     519|       7
---------------------------------------------------------------------------
  504-  518 (20.73/17.51)	LDKLKQLSKYIePLR
  541-  554 (26.28/11.95)	LDILTDPSKRC.PLK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      78.90|      23|     393|     292|     317|       8
---------------------------------------------------------------------------
  292-  317 (36.00/20.81)	PlQLPP..QSVPSQAPALSGqmLYTQQQ
  687-  711 (42.89/16.43)	P.SVPPleLSVPADYPAQSP..LWVDQQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28224 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) APMVVQQPQVQPQVQPQVQQQTTVQTPQATQMVASGVQMITAAMAQGGMQVRARFPPSTAVSAAPPGALPTGGQPPAQSAQAVWTVLTKQAPGGPLHPKSMPPLPSVSQPSAQLTADSTSGPAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLDKLKQ
2) PGFSGVNDPMNALQNLTGTPAAGATGISMAARGPGQSMGGMGSLGAMGQPPPGTSGITPHGMAVVSTAT
3) QAALQQQQQQFQAQQSAMQQQFQAAVQQQQQQLQQ
4) QQQQQQQALQAPPMQQSPMQQPQPPSAQALPQQLQQMHHPQHHQPPPPPPQQPPVAQNQPLQLPPQSVPSQAPALSGQMLYT
323
73
164
233
509
141
198
314










Molecular Recognition Features






MoRF SequenceStartStop




NANANA