<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28213

Description Cyclin dependent kinase 19
SequenceMDYDFKAKLRGAGAGEDLFEYEGCKVGRGTYGHVYKARRKDGKDEKEYALKQIEGTGISMSACREIALLRELKHPNVIALQKVFLSHSDRKVWLLFDYAEHDLWHIIKFHRASKANKKPMQLPRSMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPFHHDQLDRIFSVMGFPADKDWEDIRKMPEYPTLQKDFRRTTYANSSLIKYMEKHKVKPDSKVFLLLQRLLTMDPTKRITSEQALQDPYFQEDPLPTLDVFAGCQIPYPKREFLNEDEPEEKGEKNQQQQQNQHQQPTAPPQQAAAPPPAPPQQQNSTQTNGTAGGAGAGAGGAGPGLQHSQDAGLNQVPPNKKPRLGPSGANSGGPVMPSDYQHSSSRLNYQSSVQGSSQSQSTLGYSSSAQQSAQYHSSHQTHRY
Length501
PositionKinase
OrganismLoxodonta africana (African elephant)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Afrotheria> Proboscidea> Elephantidae> Loxodonta.
Aromaticity0.09
Grand average of hydropathy-0.691
Instability index52.90
Isoelectric point8.78
Molecular weight56425.15
Publications









Function






Annotated function


GO - Cellular Component
GO - Biological Function
ATP binding	GO:0005524	IEA:UniProtKB-UniRule
protein kinase activity	GO:0004672	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP28213
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.97|      18|      22|     373|     394|       1
---------------------------------------------------------------------------
  373-  390 (35.39/29.95)	QQQNQHQ.QPTAPPQQAAA
  397-  415 (28.58/11.33)	QQQNSTQtNGTAGGAGAGA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.93|      15|      21|     459|     477|       2
---------------------------------------------------------------------------
  463-  477 (26.31/19.56)	RLNYQSSVQGSSQSQ
  479-  493 (27.62/10.80)	TLGYSSSAQQSAQYH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.21|      16|      21|     318|     337|       3
---------------------------------------------------------------------------
  318-  333 (27.90/10.75)	DPTKRITSEQALQDPY
  337-  352 (29.30/16.10)	DPLPTLDVFAGCQIPY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.82|      23|      25|      15|      39|       4
---------------------------------------------------------------------------
   15-   39 (34.32/31.31)	GEDLFEYEGCKVgRGTyGHVYKARR
   42-   64 (40.49/25.41)	GKDEKEYALKQI.EGT.GISMSACR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     119.22|      36|      40|     186|     225|       6
---------------------------------------------------------------------------
  150-  176 (31.61/16.09)	.........DLKPANILVMGEGPE.....RGRVKIADMgFA
  179-  218 (59.27/44.56)	FNSPLKPLADLDPVVVTFWYRAPELllgaRHYTKAIDI.WA
  219-  240 (28.35/12.63)	IGCIFAELLTSEPI...FHCRQEDI................
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28213 with CDK8 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) YPKREFLNEDEPEEKGEKNQQQQQNQHQQPTAPPQQAAAPPPAPPQQQNSTQTNGTAGGAGAGAGGAGPGLQHSQDAGLNQVPPNKKPRLGPSGANSGGPVMPSDYQHSSSRLNYQSSVQGSSQSQSTLGYSSSAQQSAQYHSSHQTHRY
352
501










Molecular Recognition Features






MoRF SequenceStartStop




1) KKPRL
2) TLGYSSSA
437
479
441
486