<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28211

Description Mediator of RNA polymerase II transcription subunit 16
SequenceGIMDLAYVCEWEKWPRSTLCPSVPLACAWSCRNLIAFTTDLRNDDQDLTRMIHILDTEHPWEVHSIDSEHREAITCLEWDQSGSRLLSADADGQIKCWGMADHLANSWESPVGSLVEGDPIVALSWLHNGVKLALHVEKSGASSFGEKFSRVKFSPSLTLFGGKPMEGWIAVTVSGLVTVSLLKPSGQVLTSTESLCRLRGRVALADIAFTGGGNIVVATADGSSASPVQFYKVCVSVVSEKCRIDTEILPSLFMRCTTDLNRKDRFPAITHLKFLARDMSEQVNMCLLGLPEQTTTRWVLKQHGFIISVLGQQQASSIGDKQPMILKWRILSATNDLDRVSAVALPKLPISLTNTDLKVASDTQFYPGLGLALAFHDGSVHIVHRLSLQTMAVFYSSAAPRSVDEPAIKRPRTTGPAVHFKAMQLSWTSLALVGIDNHGKLNMLRISPSLGHTLEVSLALRHLLFLLEYCMVTGYDWWDILLHVQPGMVQSLVEKLHEEYTRQSAALQQVLSTRILAMKASLCKLSPNTVTRVCDYHAKLFLIAISSTLRSLLRPHFLNTPDKSPGDRLTEICSKITDVDIDKVMINLKTEEFVLDTNTLQALQQLLQWVGDFVLYLLASLPNQGSPLRPGHSFLRDGTSLGILRELMVVIRIWGLLKPSCLPVYTATSDTQDSMSLLFRLLTKLWICCRDEGPTSEPDEALVDECCLLPSQLLIPSLDWLPVSDGLISRLQPKQPLRLHFRAPTLPGSAAASQLDAPRPGGAPGQPKIDHLRRLHLGAYPTEECKACTRCGCVTMLKSPNKTTAVKQWEQRWIKNCLCGGLWRRMRLAYP
Length832
PositionTail
OrganismLoxodonta africana (African elephant)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Afrotheria> Proboscidea> Elephantidae> Loxodonta.
Aromaticity0.07
Grand average of hydropathy0.009
Instability index47.73
Isoelectric point8.08
Molecular weight92284.08
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP28211
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     486.82|     135|     300|     124|     270|       1
---------------------------------------------------------------------------
  124-  270 (202.23/157.15)	LSWlhngVKLALhvekSGASSFGeKFSRVKFSPSL..TLFG..GKPME......GWI......AVTVSGLVTVSL.L...KP...SGQVLTSTESLCR..LRGRVALADIAFTgggNIVVATADGSSASPVQFY..........KVC.....VSVVSEKCRIDTEILPSLF....MRCTTDLNRKDRFPAI
  285-  412 (99.98/56.65)	.................................NM..CLLGlpEQTTT......RWVlkqhgfIISVLGQQQASS.IgdkQPmilKWRILSATNDLDR..VSA.VALPKLP......ISLTNTDLKVASDTQFYpglglalafhDGS.....VHIVH...RLSLQTMAVFYssaaPRSVDEPAIKRP....
  426-  573 (184.61/115.65)	LSW....TSLAL....VGIDNHG.KLNMLRISPSLghTLEV..SLALRhllfllEYC......MVTGYDWWDILLhV...QP....GMVQSLVEKLHEeyTRQSAALQQVLST...RILAMKASLCKLSPNTVT..........RVCdyhakLFLIAISSTLRS.LLRPHF....LN.TPDKSPGDRLTEI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28211 with Med16 domain of Kingdom Metazoa
Unable to open file!