<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28210

Description Mediator of RNA polymerase II transcription subunit 13
SequenceADLTGIKWKRYVWQGPTSAPILFPVTEEDPILSSFSRCLKADVLGVWRRDQRPGRRELWIFWWGEDPNFADLIHHDLSEEEDGVWENGLSYECRTLLFKAVHNLLERCLMNRNFVRIGKWFVKPYEKDEKPINKSEHLSCSFTFFLHGDSNVCTSVEINQHQPVYLLSEEHITIAQQSNSPFQVILSPFGLNGTLTGQAFKMSDSATKKLIGEWKQFYPISSCLKEMCEEKQEDMDWEDDSLAAVEVLVAGVRMIYPACFVLVPQSDIPILSSVGSSHCSASCLGVHQVPASTRDPAMSSVTLTPPTSPEEVQTVDPQSAQKWVKFSSVSDGFNSDNTSHHGGKIPRKLANHVVDRVWQECNMNRAQNKRKYSASSGGLCEEETADKVASWDFVEATQRTNCSCSRHKSLKPRNPGQQGQAPSLGQQQQVLPKHKTNEKQEKSEKPQKRPLTPFHHRVSISDDVGMDTDSASQRLVISAPDSQVRFSNIRTNDVAKTPQMHGTEIANSPQPPPLSPHPCDVVDEGVTKTPSTPQSQHFYQMPTPDPLVPSKPMEDRIDSLSQSFPAQFQEAVEPTVYVGTAVNLEEDEANIAWKYYKVPKKKDVEFLPPQLPSDKFKDDPVGPFGQESVTSVTELMVQCKKPLKVSHELVQQYQIKNQYLSAIASDAEQEPKIDPYAFVEGDEEFLFPDKKDRQNSEREAGKKHKVEDGTSSVTVLSHEEDAMSLFSPSIKQDAPRPTSHARPPSTSLIYDSDLAVSYTDLDNLFNSDEDELTPGSKKSVNGSDDKSSCKESKAGNLDPLSCISTADLHKMYPTPPSLEQHIMGFSPMNMNNKEYGSMDTTPGGTVLEGNHSNIGAQFKIEVDEGFCSPKPSEIKDFSYVYKPENCQVLVGCSMFAPLKTLPSQCLPPIKLPEECVYRQSWTVGKLELLHSGPAMPFIKEGDGSTMDQEYGPAYTPQTHASFGMPPSSAPPSNGGAGILPSPSTPRFPTPRTPRTPRTPRGAGGPASAQGSVKYENSDLYSPASTPSTCRPLNSVEPATVPSIPEAHSLYVNLILSESVMNLFKDCNFDSCCICVCNTNIKGADVGVYIPDPTQEAQYRCTCGFSAVMNRKFGNNSGLFLEDELDIIGRNTECGKEAEKRFEALRATSAEHVNGGLKESEKLPDELILLLQDQCTNLFSPFGAADQDPFPKIGVISNWVRVEERDCCNDCYLALEHGRQFMDNMSGGKVDEALVKSSCLHPWSKRNNVSMQCSQDILRMLLSLQPVLQDAIQKKRTVRPWGVQGPLTWQQFHKIAGRGSYGTDESPEPLPIPTFLLGYDYDFLVLSPFALPYWERLMLEPYGSQRDIAYVVLCPENEALLNGAKSFFRDLTAIYESCRLGQHRPISRLLTDGIMRVGSTASKKLSENLVAEWFSQATEGNNEAFSKLKLYAQVCRYDLGPYLASQPLDSSLLSQPNLVVPTSQSLITPPQMTNTGNANTPSTTLASAASNTMTLTSGGAMSSSVATANSTLATSSSSSSNLNSGVSSNKLPSFPPFGSMNSSAAGSMSTQTATVQNGQLGGQQSSALQTPGISGESSLLSTQPHPDVSESTMDRDKVGIPTDGDSHAITYPPAIVVYIIDPFTYENKDESTNSSNVWTLGLLRCFLEMVQTLPPHIKSTVSVQIVPCQYLLQPVKHEDRQIYTQHLKSLAFSAFTQCRKPLPTSTNVKTLTGFGPGLAMETALKSPDRPECIRLYTPPFILAPVKDKQTELGETFGEAGQKYNVLFVGYCLSHDQRWILASCTDLYGELLETCVINIDVPNRYLFFPNVSSIKKINVYKYKCIKNICTYTVYWIPVTQWLSGYMEERYWSCLLSRRNLQSLSKRLKDMCRMCGISAADSPSILSACLVAMEPQGSFVIMPDSVSTGSVFGRSTTLNMQTSQLNTPQDTSCTHILVFPTSASVQVASATYTTENLDLAFNPNNDGSDGMGIFDLLDTPDDLDPDIINILPASPTGSPVHSPGSHYPHGGDTGKGQGTDRLLSTESHDEVTNILQQPLALGYFVSTAKAGPLPDWFWSACPQAQYQCPLFLKASLHLHVPSVQSDELLHSKHSHPLDSNQTSDVLRFVLEQYNALSWLTCDPAIQDRRSCLPIHFVVLNQLYNFIMNML
Length2147
PositionMiddle
OrganismLoxodonta africana (African elephant)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Afrotheria> Proboscidea> Elephantidae> Loxodonta.
Aromaticity0.08
Grand average of hydropathy-0.406
Instability index50.45
Isoelectric point5.40
Molecular weight237084.72
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP28210
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|    1581.15|     466|     500|     450|     948|       1
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  306-  745 (605.19/415.71)	............................PTSPEEVQTVDPQSAQKWVKFSSVsDGFNSDNTS..HHGGKIPRKL...ANHVVDrvWQECNMNraqNKR..KYSASSGGLCEEETADKVASWDFVEATQRTnCS..CSRHKSL....KPRN............................PGQ.....QGQAPSLG......QQQQVL..PKHKTNEKQEKSEKPQ.krP.LTPFHHRVSiSDDVGMDTDSASQR....L...VISAPDSQVRFSNIRTNDVAKTPQMHGTEIANSPQpPPLSPHPCDVVDEgvTKTPSTPQSqhfyqMPTPDP.LVPSKPMEDRIDS...LSQSFPAQFQEA.VEPTVYVGTAVNLEEDEANIawkYYKVPKKK.....DVEFlpPQLPSDKFKDDPvGPFGQESVTSVTElMVQCKKPLK........VSHELVqqyqikNQYLsaiaSDAEQEPkiDPYAFVEGDE.EFLF.PDKKDRQNSEREAG...KKHKVED...GTSSVTVLSHEEDAMSLFSPSIKQDAPRPTSHARPPS
  746- 1243 (735.29/440.58)	TSLIYDSDLAVSYTDLDNLFnsdEDELTPGSKKSVNGSDDKSSCKESKAGNL.DPLSCISTADLHKMYPTPPSL...EQHIMG..FSPMNMN...NKEYGSMDTTPGGTVLEGNHSNIGAQFKIEVDEGF.CSPKPSEIKDFSYVYKPENCQV..LVGCSMFAPLKTLPSQCLPPIKLPEECV...YRQSWTVG......KLELLHsgPAMPFIKEGDGSTMDQeygPaYTPQTH.....ASFGMPPSSAPPSnggaG...ILPSP.STPRFPTPRTPRTPRTPR..GAGGPASAQ.GSVKYENSDLYSP..ASTPSTCRP.....LNSVEPaTVPSIPEAHSLYVnliLSESVMNLFKDCnFDSCCICVCNTNIKGADVGV...YIPDPTQEaqyrcTCGF..SAVMNRKFGNNS.GLFLEDELDIIGR.NTECGKEAEkrfealraTSAEHV......NGGL....KESEKLP..DELILLLQDQcTNLFsPFGAADQDPFPKIGvisNWVRVEErdcCNDCYLALEHGRQFMDNMSGGKVDEALVKSSCLHPWS
 1248- 1480 (240.68/127.40)	VSMQCSQDILRMLLSLQPVL...QDAIQ..KKRTVRPWGVQGPLTWQQFHKI.AGRGSYGTDESPEPLPIPTFLlgyDYDFLV..LSPFALP...YWERLMLE..P.....YGSQRDIAYVVLCPENEAL.LNGAKSFFRDLTAIY..ESCRLgqHRPISRLLTDGIMRVGSTASKKLSENLVaewFSQA.TEGnneafsKLKL.............................YAQVC.RYDLG..PYLASQP....LdssLLSQPNLVVPTS....QSLITPPQMTNTGNANTP......................................................................................................................................................................................................................................................................
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     263.80|      81|    1638|     215|     301|       2
---------------------------------------------------------------------------
  215-  301 (131.13/84.46)	KQFYPISSCLKEMCeeKQEDMDWEDDSLAAVEVLVAgvrMIYPACFVLVPQSdIPILSSVGSS...HCSASCLGVHQVPASTRD...PAMSSV
 1856- 1942 (132.67/70.51)	RNLQSLSKRLKDMC..RMCGISAADSPSILSACLVA...MEPQGSFVIMPDS.VSTGSVFGRSttlNMQTSQLNTPQDTSCTHIlvfPTSASV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     175.26|      50|     506|    1528|    1614|       3
---------------------------------------------------------------------------
 1564- 1613 (87.51/76.39)	SSALQTPGISGESSLLSTQPHPDVSESTMDRDKVGIPTDGDSHAITYPPA
 2072- 2121 (87.75/31.21)	SLHLHVPSVQSDELLHSKHSHPLDSNQTSDVLRFVLEQYNALSWLTCDPA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      94.34|      30|      36|    1481|    1510|       4
---------------------------------------------------------------------------
 1481- 1510 (49.74/33.43)	STTLAS.AASNTM.TLTSGGAMSSSVATANST
 1518- 1549 (44.60/29.04)	SSNLNSgVSSNKLpSFPPFGSMNSSAAGSMST
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     262.50|      79|    1546|      75|     158|       6
---------------------------------------------------------------------------
   75-  158 (131.61/116.14)	HDLSEEEDGVWENGLsYECrtllFKAVHNLLERCLMNRNFVRIG..KWFVKPYEKDEKPINKSEHLSCSFTFFLHGDSNVCTSVEI
 1627- 1707 (130.89/100.23)	KDESTNSSNVWTLGL.LRC....FLEMVQTLPPHIKSTVSVQIVpcQYLLQPVKHEDRQIYTQHLKSLAFSAFTQCRKPLPTSTNV
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28210 with Med13 domain of Kingdom Metazoa
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