<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28206

Description Mediator of RNA polymerase II transcription subunit 13
SequenceLTGGVRMVYPSAFVLISQNDIPVPQSGTSAGGHITVGQQGLGSVKDPSNCGMPLTPPTSPEQVLIGESGGTQSAVSHLGSQEGGMITMHSPKRSGKIPPKLHNHMVHRVWKECILNRTQSKRSQVSTPTLEEEPANNPATWDFVDPTQRVSCSCSRHKLLRRCAAGPNRPPTISQPGFSAGPSSSSSLPPPASSKHKTTERQEKGDKLQKRPLIPFHHRPSVAEELCMEQDTSGQKLGLAGMDSSLEVSSSRKYDKQMAVPSRNPSKQMNLNPMDSPHSPISPLPPTLSPQPRGQETESLDPPSVPVNPALYGNGLELQQLSTLDDRTVLVGQRLPLMAEVSETALYCGIRPSNPESSDKWWHSYCLPPSDDAEFRPPELQGERCDAKMEVITESTALQRLLAQPNKRFKIWQDKQPQMQPLHFLDPLPLTQPPGDSLGEVNDPYTFEDGDIKYIFTANKKCKQGTEKDSLKKNKSEDGFGTKDVTTPGHSTPVPDGKNAMSIFSSAAKTDVRQDNAAGRAGSSSLTQVTDLAPSLHDLDNIFDNSDDDELGAVSPALRSSKMPTVGTEDRPLGKDGRTAVPYPPTVADLQRMFPTPPSLEQHPAFSPVMNYKDGISSETVTALGMMESPMVSMVSTQLTEFKMEVEDGLGSPKPEEIKDFSYVHRVPAFQPFVGSSMFAPLKMLPSQCLLPLKMPDACLFRPSWAVPPKIEHLPMPPAATFIRDGYNNVPSVGSLADPDYLNTPQMNTPVTLNSAAPASNSGAGVLPSPATPRFSVPTPRTPRTPRTPRGGGTASGQGSVKYDSTDQGSPASTPSTTRPLNSVEPATMQPIPEAHSLYVTLILSDSVMNIFKDRNFDSCCICACNMNIKGADVGLYIPDSSNEDQYRCTCGFSAIMNRKLGYNSGLFLEDELDIFGKNSDIGQAAERRLMLCQPAFLPQLEGARKPQEPPISLLLLLQNQHTQPFASLSFLDYISSNSRQTLPCVSWSYDRVQADNNDYWTECFTALEQGRQYVDNPTGGKVDEALVRSATAHSWPHSNVLDISMLSSQDVVRMLLSLQPFLQDAIQKKRTGRTWENIQHVQGPLTWQQFHKMAGRGTYGSEESPEPLPIPTLLVGCDKDFLTISPFSLPFWERLLLDPYGGHRDVAYIVVCPENEALLEGAKTFFRDLSAVYEMCRLGQHKPICKVLRDGIMRVGKTVAQKLTEELVSEWFSQPWGSEENDNHSRLKLYAQVCRHHLAPYLAALQLDSSLLIPPKYQSPPAAAQGQATPGNAGPLASNSGSAAPPAGSAFNPTTNGSSANPAASSSAPGSSMPPVSSSSSAPGINQINTTSSSGFSGSVGGQNPSSSADRTQGNISCGGDAEPGQSSSQASQDGQESVTERERIGIPTEADSADSQAYPPAVVIYMVDPFTYTSEEDSTSGNFWLLSLMRCYTEMLDNLPEHMRNSFILQIVPCQYMLQTMKDEQVFYIQYLKSMAFSVYCQCRRPLPTQIHIKSLTGFGPAASIEMTLKNPERPSPIQLYSPPFILAPIKDKQTELGETFGEASQKYNVLFVGYCLSHDQRWLLASCTDLHGELLETCIVNIALPNRSRRSKVSARKIGLQKLWEWCVGIVQMTSLPWRVVIGRLGRLGHGELKDWSILLGECSLQTISKQLKDVCRMCGISAADSPSILSACLVAMEPQGSFVVMPDAVTMGSVFGRSTALNMQSAQLSTPQDASCTHILVFPTSSTIQVAPANYPNEDGFSPNNDDMFVDLPFPDDMDNDIGILMTGNLHSSPNSSPVPSPGSPSGIGVGSHFQHSRSQGERLLSREAPEELKQQPLALGYFVSTAKAENLPQWFWSSCPQAQNQCPLFLKASLHHHISVAQTDELLPARNSQRVPHPLDSKTTSDVLRFVLEQYNALSWLTCNPATQDRTSCLPVHFVVLTQLYNAIMNIL
Length1937
PositionMiddle
OrganismLoxodonta africana (African elephant)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Afrotheria> Proboscidea> Elephantidae> Loxodonta.
Aromaticity0.07
Grand average of hydropathy-0.399
Instability index60.79
Isoelectric point5.74
Molecular weight211192.35
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364134

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP28206
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     150.09|      27|      28|    1261|    1287|       1
---------------------------------------------------------------------------
  134-  155 (30.70/10.43)	.P..ANNPATWD.FVDPTQRVS..CSCS..
  170-  191 (37.80/14.80)	PPTISQ....PGfSAGP..SSS..SSLPPP
 1261- 1287 (51.58/23.27)	PPAAAQGQATPG.NAGPLASNS..GSAAPP
 1290- 1316 (30.01/10.01)	...SAFNPTTNGsSANPAASSSapGSSMPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     116.33|      28|      28|     763|     790|       2
---------------------------------------------------------------------------
  734-  764 (37.25/16.66)	GSLADPdylNTPQMNTPVTLNS.AAPASNSGA
  765-  792 (50.91/26.12)	GVLPSP...ATPRFSVPTPRTP.RTPRTPRGG
  793-  819 (28.17/10.37)	GTASGQ...GSVKYDSTDQGSPaSTPSTTR..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.16|      11|      28|    1117|    1127|       3
---------------------------------------------------------------------------
 1117- 1127 (21.68/12.47)	GCDKD..FLTISP
 1142- 1154 (17.49/ 8.58)	GGHRDvaYIVVCP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     464.03|     139|     465|     871|    1090|       4
---------------------------------------------------------------------------
  940- 1086 (227.16/195.65)	QLegaRKPQEPPISLLLLLQNQHTQPFASLSF..LDYISSNSRQTLPCVSWSYDRvqadNNDYWTECFTALEQGRQYVDNPTGGKVDEALVRSATAHSWPHSNVLdISMLSSQDVVRMLLSLQPFLQDAIQKKRTGRTWENIQHVQG..PL
 1711- 1853 (236.87/93.70)	QL...STPQDASCTHILVFPTSSTIQVAPANYpnEDGFSPNNDDMFVDLPFPDDM....DNDIGILMTGNLHSSPNSSPVPSPGSPSGIGVGSHFQHSRSQGERL.LSREAPEELKQQPLALGYFVSTAKAENLPQWFWSSCPQAQNqcPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     210.55|      64|     109|     205|     273|       5
---------------------------------------------------------------------------
  205-  273 (98.80/65.80)	GDKLQKRPLIPFHHRPS.VAEELCMEQDTSGQKLgLAGMDSSlEVSSSRKYDKQMAVPsrnPSKQMNLNP
  313-  377 (111.74/59.64)	GNGLELQQLSTLDDRTVlVGQRLPLMAEVSETAL.YCGIRPS.NPESSDKWWHSYCLP...PSDDAEFRP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     170.22|      52|     465|     871|     927|       6
---------------------------------------------------------------------------
  871-  927 (82.69/54.75)	GAdVGLYIPDSS.NEDQYRCTCGFSAimnrKLGYNSGLFLEDELDIFGKNSDIGQAAE
 1339- 1391 (87.53/45.74)	GS.VGGQNPSSSaDRTQGNISCGGDA....EPGQSSSQASQDGQESVTERERIGIPTE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     390.84|      99|     109|     510|     615|       7
---------------------------------------------------------------------------
  419-  500 (95.02/41.75)	.......................MQP.LHFLDPLpLTQPPGDSLGEVNdPyTFE.DGDIKYIFTAN.KKC.K.QGteKDSLKKN.KSEDGFGTKDVTTPG...HS..TPVPDG.KNA
  510-  615 (156.11/88.25)	TdvrqdnAAGRAGSSSLTQV.TDLAPSLHDLDNI.FDNSDDDELGAVS.P.ALR.SSKMPTVGTED.RPLGK.DG..RTAVPYP.PTVADLQRMFPTPPSLEQHPaFSPVMNY.KDG
  622-  726 (139.72/66.94)	T......ALGMMESPMVSMVsTQLTEFKMEVEDG.LGSPKPEEIKDFS.Y.VHRvPAFQPFVGSSMfAPLKMlPS..QCLLPLKmPDACLFRPSWAVPPKIEHLP.MPPAATFiRDG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.08|      23|      26|    1467|    1492|       8
---------------------------------------------------------------------------
 1470- 1492 (45.78/30.83)	YIQYLKSM..AFSVYCQCR...RPLPTQ
 1494- 1521 (28.29/ 9.70)	HIKSLTGFgpAASIEMTLKnpeRPSPIQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.69|      25|      27|    1585|    1611|       9
---------------------------------------------------------------------------
 1585- 1611 (39.91/31.26)	I...ALPNRSRRSKVSarKIGLQKLWEWCV
 1614- 1641 (39.78/24.51)	VqmtSLPWRVVIGRLG..RLGHGELKDWSI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28206 with Med13 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) CAAGPNRPPTISQPGFSAGPSSSSSLPPPASSKHKTTERQEKGDKLQKRPLIPFHHRPSVAEELCMEQDTSGQKLGLAGMDSSLEVSSSRKYDKQMAVPSRNPSKQMNLNPMDSPHSPISPLPPTLSPQPRGQETESLDPPSVPVNPALYG
2) GILMTGNLHSSPNSSPVPSPGSPSGIGVGSHFQHSRSQGERLLSREAPE
3) GTEKDSLKKNKSEDGFGTKDVTTPGHSTPVPDGKNAMSIFSSAAKTDVRQDNAAGRAGSSSLTQVTDLAPSLHDLDNIFDNSDDDELGAVSPALRSSKMPTVGTEDRPLGKDGRTAVP
4) PKYQSPPAAAQGQATPGNAGPLASNSGSAAPPAGSAFNPTTNGSSANPAASSSAPGSSMPPVSSSSSAPGINQINTTSSSGFSGSVGGQNPSSSADRTQGNISCGGDAEPGQSSSQASQDGQESVTERERIGIPTEADS
5) PQSGTSAGGHITVGQQGLGSVKDPSNCGMPLTPPTSPEQVLIGESGGTQSAVSHLGSQEGGMITMHSPKRSGKIPPKLH
6) VGSLADPDYLNTPQMNTPVTLNSAAPASNSGAGVLPSPATPRFSVPTPRTPRTPRTPRGGGTASGQGSVKYDSTDQGSPASTPSTTRPLNSVEPATMQ
163
1767
465
1256
24
733
313
1815
582
1394
102
830










Molecular Recognition Features






MoRF SequenceStartStop




NANANA