<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28203

Description Mediator of RNA polymerase II transcription subunit 13
SequenceFLQADLTGIKWKRYVWQGPTSAPILFPVTEEDPILSSFSRCLKADVLGVWRRDQRPGRRELWIFWWGEDPNFADLIHHDLSEEEDGVWENGLSYECRTLLFKAVHNLLERCLMNRNFVRIGKWFVKPYEKDEKPINKSEHLSCSFTFFLHGDSNVCTSVEINQHQPVYLLSEEHITIAQQSNSPFQVILSPFGLNGTLTGQAFKMSDSATKKLIGEWKQFYPISSCLKEMCEEKQEDMDWEDDSLAAVEVLVAGVRMIYPACFVLVPQSDIPILSSVGSSHCSASCLGVHQVPASTRDPAMSSVTLTPPTSPEEVQTVDPQSAQKWVKFSSVSDGFNSDNTSHHGGKIPRKLANHVVDRVWQECNMNRAQNKRKYSASSGGLCEEETADKVASWDFVEATQRTNCSCSRHKSLKPRNPGQQGQAPSLGQQQQVLPKHKTNEKQEKSEKPQKRPLTPFHHRVSISDDVGMDTDSASQRLVISAPDSQVRFSNIRTNDVAKTPQMHGTEIANSPQPPPLSPHPCDVVDEGVTKTPSTPQSQHFYQMPTPDPLVPSKPMEDRIDSLSQSFPAQFQEAVEPTVYVGTAVNLEEDEANIAWKYYKVPKKKDVEFLPPQLPSDKFKDDPVGPFGQESVTSVTELMVQCKKPLKVSHELVQQYQIKNQYLSAIASDAEQEPKIDPYAFVEGDEEFLFPDKKDRQNSEREAGKKHKVEDGTSSVTVLSHEEDAMSLFSPSIKLTYVDAPRPTSHARPPSTSLIYDSDLAVSYTDLDNLFNSDEDELTPGSKKSVNGSDDKSSCKESKAGNLDPLSCISTADLHKMYPTPPSLEQHIMGFSPMNMNNKEYGSMDTTPGGTVLEGNHSNIGAQFKIEVDEGFCSPKPSEIKDFSYVYKPENCQVLVGCSMFAPLKTLPSQCLPPIKLPEECVYRQSWTVGKLELLHSGPAMPFIKEGDGSTMDQEYGPAYTPQTHASFGMPPSSAPPSNGGAGILPSPSTPRFPTPRTPRTPRTPRGAGGPASAQGSVKYENSDLYSPASTPSTCRPLNSVEPATVPSIPEAHSLYVNLILSESVMNLFKDCNFDSCCICVCNTNIKGADVGVYIPDPTQEAQYRCTCGFSAVMNRKFGNNSGLFLEDELDIIGRNTECGKEAEKRFEALRATSAEHVNGGLKESEKLPDELILLLQDQCTNLFSPFGAADQDPFPKIGVISNWVRVEERDCCNDCYLALEHGRQFMDNMSGGKVDEALVKSSCLHPWSKRNIVDVSMQCSQDILRMLLSLQPVLQDAIQKKRTVRPWGVQGPLTWQQFHKIAGRGSYGTDESPEPLPIPTFLLGYDYDFLVLSPFALPYWERLMLEPYGSQRDIAYVVLCPENEALLNGAKSFFRDLTAIYESCRLGQHRPISRLLTDGIMRVGSTASKKLSENLVAEWFSQATEGNNEAFSKLKLYAQVCRYDLGPYLASQPLDSSLLSQPNLVVPTSQSLITPPQMTNTGNANTPSTTLASAASNTMTLTSGGAMSSSVATANSTLATSSSSSSNLNSGVSSNKLPSFPPFGSMNSSAAGSMSTQTATVQNGQLGGQQSSALQTPGISGESSLLSTQPHPDVSERISTMDRDKVGIPTDGDSHAITYPPAIVVYIIDPFTYENKDESTNSSNVWTLGLLRCFLEMVQTLPPHIKSTVSVQIVPCQYLLQPVKHEDRQIYTQHLKSLAFSAFTQCRKPLPTSTNVKTLTGFGPGLAMETALKSPDRPECIRLYTPPFILAPVKDKQTELGETFGEAGQKYNVLFVGYCLSHDQRWILASCTDLYGELLETCVINIDVPNRLHRQKRERFLNSVFSLFSYCIEAVCVPLKPYLSIQNIMQRLSVLIPTDWSCLLSRRNLQSLSKRLKDMCRMCGISAADSPSILSACLVAMEPQGSFVIMPDSVSTGSVFGRSTTLNMQTSQLNTPQDTSCTHILVFPTSASVQVASATYTTENLDLAFNPNNDGSDGMGIFDLLDTPDDLDPDIINILPASPTGSPVHSPGSHYPHGGDTGKGQGTDRLLSTESHDEVTNILQQPLALGYFVSTAKAGPLPDWFWSACPQAQYQCPLFLKASLHLHVPSVQSDELLHSKHSHPLDSNQTSDVLRFVLEQYNALSWLTCDPAIQDRRSCLPIHFVVLNQLYNFIMNML
Length2159
PositionMiddle
OrganismLoxodonta africana (African elephant)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Afrotheria> Proboscidea> Elephantidae> Loxodonta.
Aromaticity0.08
Grand average of hydropathy-0.387
Instability index50.13
Isoelectric point5.39
Molecular weight238277.27
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:Ensembl
nucleoplasm	GO:0005654	IEA:Ensembl

GO - Biological Function
thyroid hormone receptor binding	GO:0046966	IEA:Ensembl
transcription coactivator activity	GO:0003713	IEA:Ensembl

GO - Biological Process
cholesterol homeostasis	GO:0042632	IEA:Ensembl
negative regulation of DNA-binding transcription factor activity	GO:0043433	IEA:Ensembl
positive regulation of transcription initiation from RNA polymerase II promoter	GO:0060261	IEA:Ensembl
triglyceride homeostasis	GO:0070328	IEA:Ensembl









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP28203
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     231.10|     107|     203|     308|     423|       1
---------------------------------------------------------------------------
  308-  363 (45.29/34.21)	...........................................................................................................................................................PPTSPEEVQTVDpQSAQkwvKFSSV..SDGFNSDNTShhGGKIPRKLANHVVDRVWQE
  364-  423 (64.74/39.54)	CNMNRAQNKRKYSASSGGLcEEETADkVAsWDFVEATQRTNCSC..SRHKSLKPR.NP.GQQGQ.....................................................................................................................................................
  515-  566 (58.53/25.06)	................................................................apslgqqqqvlpkhktnekqeksekpqkrpltpfhhrvsisddvgmdtdsasqrlvisapdsqvrfsnirtndvaktpqmhgteianspqpPPLSPHPCDVVD.EGVT...KTPSTpqSQHFYQMPTP..DPLVPSKPMEDRIDSLSQS
  569-  629 (62.55/26.72)	AQFQEAVEPTVYVGTAVNL.EEDEAN.IA.WKYYKVPKKKDVEFlpPQLPSDKFKdDPvGPFGQ.....................................................................................................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     130.22|      38|     203|    1711|    1748|       2
---------------------------------------------------------------------------
 1711- 1748 (66.93/43.71)	LPTSTNVKTLTGFGPGLAMETA.LKSPDRPECIRLYTPP
 1911- 1949 (63.29/40.84)	MPDSVSTGSVFGRSTTLNMQTSqLNTPQDTSCTHILVFP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     143.51|      46|     423|    1410|    1461|       3
---------------------------------------------------------------------------
 1410- 1461 (61.49/58.45)	KKLSENLVAEWFSQATEGNNEAFSKlKLyAQVCRYdLGPYLASQPldsSLLS
 1851- 1896 (82.03/51.75)	QRLSVLIPTDWSCLLSRRNLQSLSK.RL.KDMCRM.CGISAADSP...SILS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     106.58|      31|     209|     813|     893|       5
---------------------------------------------------------------------------
  820-  850 (57.58/77.40)	TPPSLEQHIMGFSP.MNMNNKEYGSMDTTPGG
 1475- 1506 (49.01/ 6.96)	TPPQMTNTGNANTPsTTLASAASNTMTLTSGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     155.10|      45|     503|     453|     513|      12
---------------------------------------------------------------------------
  455-  505 (72.25/54.88)	TPFHHrvsisDDVGMDTDSASQR....LVISAPdSQVRFSNIRTNDVAKTPQMHG
  961- 1009 (82.85/33.96)	TPQTH.....ASFGMPPSSAPPSnggaGILPSP.STPRFPTPRTPRTPRTPRGAG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      96.42|      30|     502|    1017|    1048|      16
---------------------------------------------------------------------------
 1017- 1048 (48.63/33.22)	SVKYENSDLYSPASTPSTCRplNSVEPATVPS
 1511- 1540 (47.80/26.13)	SVATANSTLATSSSSSSNLN..SGVSSNKLPS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28203 with Med13 domain of Kingdom Metazoa
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