<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28193

Description Mediator of RNA polymerase II transcription subunit 1
SequenceMKAQGEAEESEKLNKMSSLLERLHAKFNQNRPWSETIKLVRQVMEKRVVMSSGGHQHLVSCLETLQKALKVTSLPAMTDRLESIARQNGLGSHLSASGTECYITSDMFYVEVQLDPAGQLCDVKVAHHGENPVSCPELVQQLREKNFDEFSKHLKGLVNLYNLPGDNKLKTKMYLALQSLEQDLSKMAIMYWKATNASPLDKILHGSVGYLTPRSGGHLMNLKYYASPSDLLDDKTTSPIILHENIVPRSLGMNASVTIEGTSAMYKLPIAPLIMGSHPVDNKWTPSFSSITSANSVDLPACFFLKFPQPIPVSRAFVQKLQNCTGIPLFEAQPTYVPLYELITQFELSKDPDPIPLNHNMRFYAALPGQQHCYFLNKDAPLPDGRSLQGTLVSKITFQHPGRVPLILNLIRHQVAYNTLIGSCVKRTILKEDCPGLLQFEVCPLSESRFSVSFQHPVNDSLVCVVMDVQDSTHVSCKLYKGLSDALICTDDFIAKVVQRCMSIPVTMRAIRRKAETIQADTPALSLIAETVEDMVKKNLPPASSPGYGMTTGNNPMSGTTTPTNTFPGGPITTLFNMSMSIKDRHESVGHGEDFSKVSQNPILTSLLQITGNGGSTIGSSPTPPHHTPPPVSSMAGNTKNHPMLMNLLKDNPAQDFSTLYGSSPLERQNSSSGSPRMEMCSGSNKTKKKKSSRLPPDKPKHQTEDDFQRELFSMDVDSQNPIFDVNMTADALDTPHITPAPSQCSTPPTTYPQPIPHPQPSIQRMVRLSSSDSIGPDVTDILSDIAEEASKLPSTSDDCPPIGTPVRDSSSSGHSQSALFDPDVFQTNNNENPYTDPADLIADAAGSPSSDSPTNHFFPDGVDFNPDLLNSQSQSGFGEEYFDESSQSGDNDDFKGFASQALNTLGVPMLGGDNGETKFKGNSQADTVDFSIITVAGKALGPADIMEHHSGSQSPLLTTGDLGKEKTQKRVKEGNGTSNSSLSGPGLDSKPGKRSRTPSNDSKSKDKPPKRKKADTEGKSPSHSSSNRPFTPPTSTGGSKSPGSSGRSQTPPGVATPPIPKITIQIPKGTVMVSKSSSHSQYTSSGSVSSSGSKSHHSHSSSSSSSSASTSGKMKSSKSEGSSSSKLSSSMYSSQGSSGSSQSKNSSQSGGKPGSSPITKHGLSSGSSSTKMKPQGKPSSLMNPSLSKPNISPSHSRPPGASDKLASPMKPVPGTPPSSKAKSPISSGSGGSHISGTSSSSGMKSSGLGSSGSLSQKTPPSSNSCTASSSSFSSSGSSMSSSQNQHGSSKGKSPSRNKKPSLTAVIDKLKHGVVTSGPGGEDQMDGQMGVSTNSSHPMSSKHNMSGGEFQGKREKSDKDKSKVSTSGGSVDSSKKTSESKNVGSTGVAKIIISKHDGGSPSIKAKVTLQKPGESSGEGLRPQMASSKNYGSPLISGSTPKHERGSPSHSKSPAYTPQNLDSESESGSSIAEKSYQNSPSSDDGIRPLPEYSTEKHKKHKKEKKKDKDRDKKKSHSIKPENWSKSPISSDQSLSLTSNTILSADRPSRLSPDFMIGEEDDDLMDVALIGN
Length1570
PositionMiddle
OrganismLoxodonta africana (African elephant)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Afrotheria> Proboscidea> Elephantidae> Loxodonta.
Aromaticity0.04
Grand average of hydropathy-0.657
Instability index54.70
Isoelectric point8.84
Molecular weight167207.94
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:Ensembl
nucleolus	GO:0005730	IEA:Ensembl
nucleoplasm	GO:0005654	IEA:Ensembl

GO - Biological Function
DNA binding	GO:0003677	IEA:Ensembl
estrogen receptor binding	GO:0030331	IEA:Ensembl
LBD domain binding	GO:0050693	IEA:Ensembl
nuclear receptor coactivator activity	GO:0030374	IEA:Ensembl
peroxisome proliferator activated receptor binding	GO:0042975	IEA:Ensembl
promoter-specific chromatin binding	GO:1990841	IEA:Ensembl
protein-containing complex binding	GO:0044877	IEA:Ensembl
retinoic acid receptor binding	GO:0042974	IEA:Ensembl
thyroid hormone receptor binding	GO:0046966	IEA:Ensembl
transcription corepressor activity	GO:0003714	IEA:Ensembl
vitamin D receptor binding	GO:0042809	IEA:Ensembl

GO - Biological Process
androgen biosynthetic process	GO:0006702	IEA:Ensembl
angiogenesis	GO:0001525	IEA:Ensembl
animal organ regeneration	GO:0031100	IEA:Ensembl
brain development	GO:0007420	IEA:Ensembl
cell morphogenesis	GO:0000902	IEA:Ensembl
cellular response to epidermal growth factor stimulus	GO:0071364	IEA:Ensembl
cellular response to hepatocyte growth factor stimulus	GO:0035729	IEA:Ensembl
cellular response to thyroid hormone stimulus	GO:0097067	IEA:Ensembl
embryonic heart tube development	GO:0035050	IEA:Ensembl
embryonic hemopoiesis	GO:0035162	IEA:Ensembl
embryonic hindlimb morphogenesis	GO:0035116	IEA:Ensembl
embryonic placenta development	GO:0001892	IEA:Ensembl
enucleate erythrocyte development	GO:0048822	IEA:Ensembl
epithelial cell proliferation involved in mammary gland duct elongation	GO:0060750	IEA:Ensembl
fat cell differentiation	GO:0045444	IEA:Ensembl
intracellular steroid hormone receptor signaling pathway	GO:0030518	IEA:Ensembl
keratinocyte differentiation	GO:0030216	IEA:Ensembl
lactation	GO:0007595	IEA:Ensembl
lens development in camera-type eye	GO:0002088	IEA:Ensembl
liver development	GO:0001889	IEA:Ensembl
mammary gland branching involved in pregnancy	GO:0060745	IEA:Ensembl
mammary gland branching involved in thelarche	GO:0060744	IEA:Ensembl
megakaryocyte development	GO:0035855	IEA:Ensembl
monocyte differentiation	GO:0030224	IEA:Ensembl
mRNA transcription by RNA polymerase II	GO:0042789	IEA:Ensembl
negative regulation of apoptotic process	GO:0043066	IEA:Ensembl
negative regulation of keratinocyte proliferation	GO:0010839	IEA:Ensembl
negative regulation of neuron differentiation	GO:0045665	IEA:Ensembl
negative regulation of transcription by RNA polymerase II	GO:0000122	IEA:Ensembl
peroxisome proliferator activated receptor signaling pathway	GO:0035357	IEA:Ensembl
positive regulation of erythrocyte differentiation	GO:0045648	IEA:Ensembl
positive regulation of G0 to G1 transition	GO:0070318	IEA:Ensembl
positive regulation of gene expression	GO:0010628	IEA:Ensembl
positive regulation of hepatocyte proliferation	GO:2000347	IEA:Ensembl
positive regulation of interferon-gamma-mediated signaling pathway	GO:0060335	IEA:Ensembl
positive regulation of intracellular estrogen receptor signaling pathway	GO:0033148	IEA:Ensembl
positive regulation of keratinocyte differentiation	GO:0045618	IEA:Ensembl
positive regulation of transcription initiation from RNA polymerase II promoter	GO:0060261	IEA:Ensembl
protein import into nucleus	GO:0006606	IEA:Ensembl
regulation of vitamin D receptor signaling pathway	GO:0070562	IEA:Ensembl
retinal pigment epithelium development	GO:0003406	IEA:Ensembl
thyroid hormone generation	GO:0006590	IEA:Ensembl
thyroid hormone mediated signaling pathway	GO:0002154	IEA:Ensembl
ventricular trabecula myocardium morphogenesis	GO:0003222	IEA:Ensembl









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP28193
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|     323.10|      46|      51|    1075|    1120|       1
---------------------------------------------------------------------------
  791-  826 (37.11/ 6.16)	.......SKLPSTS...DDCPP...I..GT.PVRDSSSSGH..S.......QSALFD..PD..VF...
  827-  872 (39.75/ 7.17)	.......QTNNNENPYTDPADLIADA..AG.SPSSDSPTNHffP.......DGVDFN..PD..LLN.S
  967- 1015 (45.19/ 9.25)	KT.....QKRVKEGNGTSNSSLSGPGldSKpGKRSRTPSND..S.......KSKDKP..PK..RKK.A
 1020- 1068 (43.71/ 8.68)	KS....pSHSSSNRPFTP..PTSTGG..SK.SPGSSGRSQT..P.......PGVATPpiPKitIQI.P
 1069- 1118 (72.44/19.64)	KG.tvmvSKSSSHSQYTSSGSVSSSG..SK.SHHSHSSSSS..S.......SSASTS..GK..MKS.S
 1119- 1177 (43.73/ 8.69)	KSegsssSKLSS.SMYSSQGSSGSSQ..SKnSSQSGGKPGS..SpitkhglSSGSSS..TK..MKPqG
 1428- 1462 (41.17/ 7.71)	.............KNY...GSPLISG..ST.PKHERGSPSH..S.......KSPAYT..PQ..NLD.S
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|     290.89|      39|      40|    1216|    1254|       2
---------------------------------------------------------------------------
  615-  653 (39.55/10.43)	G....STIGSSPT......pphhTPP.......PVSSMAGNtkNHPML.....MNLLKDNP
 1216- 1245 (45.78/13.28)	.......................TPPSSKAK.SPISSGSGG..SHISG.....TSSSSGMK
 1246- 1287 (51.07/15.71)	S....SGLGSSGS......lsqkTPPSSNS..CTASSSSFS..SSGSS.....MSSSQNQH
 1288- 1340 (32.70/ 7.29)	G....SSKGKSPS...rnkkpslTAVIDKLKhGVVTSGPGG.eDQMDGqmgvsTNSSHPMS
 1341- 1379 (34.66/ 8.19)	SkhnmSGGEFQGK..........REKSDKDK.SKVST.SGG..SVDSS.....KKTSE...
 1380- 1425 (36.28/ 8.93)	S....KNVGSTGVakiiiskhdgGSPSIKAK.VTLQK.PGE..S..SG.....EGLRPQMA
 1508- 1546 (50.85/15.61)	D....RDKKKSHS..........IKPENWSK.SPISSDQSL..SLTSN.....TILSADRP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.26|      17|      20|     541|     558|       3
---------------------------------------------------------------------------
  541-  558 (29.44/17.68)	PPASSPGYGMTTGNNpMS
  563-  579 (31.83/14.19)	PTNTFPGGPITTLFN.MS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      59.91|      13|      21|     890|     902|       4
---------------------------------------------------------------------------
  890-  902 (25.72/15.10)	GDNDD..FKGFA.SQA
  913-  926 (17.81/ 7.95)	GDNGEtkFKG.N.SQA
  942-  955 (16.39/ 6.66)	GPADI..MEHHSgSQS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     221.99|      49|      50|     324|     373|       5
---------------------------------------------------------------------------
  272-  322 (41.78/19.88)	........PLiMGSHPVdnkWTPSFSSITsansvdlpaCFFL.KFPQPIPVSRA...F...VQKL...Q..
  324-  373 (89.70/57.28)	CTGI....PL.FEAQPT...YVPLYELIT.........QFELSKDPDPIPLNHNM.RF...YAALPGQQhC
  375-  424 (49.65/25.48)	..FLnkdaPL.PDGRSL...QGTLVSKIT.........FQH....PGRVPLILNLiRHqvaYNTLIGS..C
  434-  462 (40.86/19.26)	CPGL....LQ.FEV.......CPLSE..S.........RFSVSFQH...PVNDSL................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     102.84|      38|      50|     150|     199|       6
---------------------------------------------------------------------------
  165-  213 (52.04/53.42)	GDNKLKTKMYLALQSLEQDlskmaimywKATnaSP...............LDKILHGSVG.YLTP
  216-  269 (50.81/32.75)	GGHLMNLKYYASPSDLLDD.........KTT..SPiilhenivprslgmnASVTIEGTSAmYKLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     100.04|      29|      52|     696|     726|       8
---------------------------------------------------------------------------
  696-  726 (49.63/32.85)	PP...DKPKHQTEDDFQRELFSMDVDSQNPifDV
  748-  779 (50.41/27.19)	PPttyPQPIPHPQPSIQRMVRLSSSDSIGP..DV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28193 with Med1 domain of Kingdom Metazoa
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