Description | Mediator of RNA polymerase II transcription subunit 1 |
Sequence | MKAQGEAEESEKLNKMSSLLERLHAKFNQNRPWSETIKLVRQVMEKRVVMSSGGHQHLVSCLETLQKALKVTSLPAMTDRLESIARQNGLGSHLSASGTECYITSDMFYVEVQLDPAGQLCDVKVAHHGENPVSCPELVQQLREKNFDEFSKHLKGLVNLYNLPGDNKLKTKMYLALQSLEQDLSKMAIMYWKATNASPLDKILHGSVGYLTPRSGGHLMNLKYYASPSDLLDDKTTSPIILHENIVPRSLGMNASVTIEGTSAMYKLPIAPLIMGSHPVDNKWTPSFSSITSANSVDLPACFFLKFPQPIPVSRAFVQKLQNCTGIPLFEAQPTYVPLYELITQFELSKDPDPIPLNHNMRFYAALPGQQHCYFLNKDAPLPDGRSLQGTLVSKITFQHPGRVPLILNLIRHQVAYNTLIGSCVKRTILKEDCPGLLQFEVCPLSESRFSVSFQHPVNDSLVCVVMDVQDSTHVSCKLYKGLSDALICTDDFIAKVVQRCMSIPVTMRAIRRKAETIQADTPALSLIAETVEDMVKKNLPPASSPGYGMTTGNNPMSGTTTPTNTFPGGPITTLFNMSMSIKDRHESVGHGEDFSKVSQNPILTSLLQITGNGGSTIGSSPTPPHHTPPPVSSMAGNTKNHPMLMNLLKDNPAQDFSTLYGSSPLERQNSSSGSPRMEMCSGSNKTKKKKSSRLPPDKPKHQTEDDFQRELFSMDVDSQNPIFDVNMTADALDTPHITPAPSQCSTPPTTYPQPIPHPQPSIQRMVRLSSSDSIGPDVTDILSDIAEEASKLPSTSDDCPPIGTPVRDSSSSGHSQSALFDPDVFQTNNNENPYTDPADLIADAAGSPSSDSPTNHFFPDGVDFNPDLLNSQSQSGFGEEYFDESSQSGDNDDFKGFASQALNTLGVPMLGGDNGETKFKGNSQADTVDFSIITVAGKALGPADIMEHHSGSQSPLLTTGDLGKEKTQKRVKEGNGTSNSSLSGPGLDSKPGKRSRTPSNDSKSKDKPPKRKKADTEGKSPSHSSSNRPFTPPTSTGGSKSPGSSGRSQTPPGVATPPIPKITIQIPKGTVMVSKSSSHSQYTSSGSVSSSGSKSHHSHSSSSSSSSASTSGKMKSSKSEGSSSSKLSSSMYSSQGSSGSSQSKNSSQSGGKPGSSPITKHGLSSGSSSTKMKPQGKPSSLMNPSLSKPNISPSHSRPPGASDKLASPMKPVPGTPPSSKAKSPISSGSGGSHISGTSSSSGMKSSGLGSSGSLSQKTPPSSNSCTASSSSFSSSGSSMSSSQNQHGSSKGKSPSRNKKPSLTAVIDKLKHGVVTSGPGGEDQMDGQMGVSTNSSHPMSSKHNMSGGEFQGKREKSDKDKSKVSTSGGSVDSSKKTSESKNVGSTGVAKIIISKHDGGSPSIKAKVTLQKPGESSGEGLRPQMASSKNYGSPLISGSTPKHERGSPSHSKSPAYTPQNLDSESESGSSIAEKSYQNSPSSDDGIRPLPEYSTEKHKKHKKEKKKDKDRDKKKSHSIKPENWSKSPISSDQSLSLTSNTILSADRPSRLSPDFMIGEEDDDLMDVALIGN |
Length | 1570 |
Position | Middle |
Organism | Loxodonta africana (African elephant) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Afrotheria> Proboscidea> Elephantidae> Loxodonta. |
Aromaticity | 0.04 |
Grand average of hydropathy | -0.657 |
Instability index | 54.70 |
Isoelectric point | 8.84 |
Molecular weight | 167207.94 |
Publications |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364059 |
GO - Cellular Component | mediator complex GO:0016592 IEA:Ensembl nucleolus GO:0005730 IEA:Ensembl nucleoplasm GO:0005654 IEA:Ensembl |
GO - Biological Function | DNA binding GO:0003677 IEA:Ensembl estrogen receptor binding GO:0030331 IEA:Ensembl LBD domain binding GO:0050693 IEA:Ensembl nuclear receptor coactivator activity GO:0030374 IEA:Ensembl peroxisome proliferator activated receptor binding GO:0042975 IEA:Ensembl promoter-specific chromatin binding GO:1990841 IEA:Ensembl protein-containing complex binding GO:0044877 IEA:Ensembl retinoic acid receptor binding GO:0042974 IEA:Ensembl thyroid hormone receptor binding GO:0046966 IEA:Ensembl transcription corepressor activity GO:0003714 IEA:Ensembl vitamin D receptor binding GO:0042809 IEA:Ensembl |
GO - Biological Process | androgen biosynthetic process GO:0006702 IEA:Ensembl angiogenesis GO:0001525 IEA:Ensembl animal organ regeneration GO:0031100 IEA:Ensembl brain development GO:0007420 IEA:Ensembl cell morphogenesis GO:0000902 IEA:Ensembl cellular response to epidermal growth factor stimulus GO:0071364 IEA:Ensembl cellular response to hepatocyte growth factor stimulus GO:0035729 IEA:Ensembl cellular response to thyroid hormone stimulus GO:0097067 IEA:Ensembl embryonic heart tube development GO:0035050 IEA:Ensembl embryonic hemopoiesis GO:0035162 IEA:Ensembl embryonic hindlimb morphogenesis GO:0035116 IEA:Ensembl embryonic placenta development GO:0001892 IEA:Ensembl enucleate erythrocyte development GO:0048822 IEA:Ensembl epithelial cell proliferation involved in mammary gland duct elongation GO:0060750 IEA:Ensembl fat cell differentiation GO:0045444 IEA:Ensembl intracellular steroid hormone receptor signaling pathway GO:0030518 IEA:Ensembl keratinocyte differentiation GO:0030216 IEA:Ensembl lactation GO:0007595 IEA:Ensembl lens development in camera-type eye GO:0002088 IEA:Ensembl liver development GO:0001889 IEA:Ensembl mammary gland branching involved in pregnancy GO:0060745 IEA:Ensembl mammary gland branching involved in thelarche GO:0060744 IEA:Ensembl megakaryocyte development GO:0035855 IEA:Ensembl monocyte differentiation GO:0030224 IEA:Ensembl mRNA transcription by RNA polymerase II GO:0042789 IEA:Ensembl negative regulation of apoptotic process GO:0043066 IEA:Ensembl negative regulation of keratinocyte proliferation GO:0010839 IEA:Ensembl negative regulation of neuron differentiation GO:0045665 IEA:Ensembl negative regulation of transcription by RNA polymerase II GO:0000122 IEA:Ensembl peroxisome proliferator activated receptor signaling pathway GO:0035357 IEA:Ensembl positive regulation of erythrocyte differentiation GO:0045648 IEA:Ensembl positive regulation of G0 to G1 transition GO:0070318 IEA:Ensembl positive regulation of gene expression GO:0010628 IEA:Ensembl positive regulation of hepatocyte proliferation GO:2000347 IEA:Ensembl positive regulation of interferon-gamma-mediated signaling pathway GO:0060335 IEA:Ensembl positive regulation of intracellular estrogen receptor signaling pathway GO:0033148 IEA:Ensembl positive regulation of keratinocyte differentiation GO:0045618 IEA:Ensembl positive regulation of transcription initiation from RNA polymerase II promoter GO:0060261 IEA:Ensembl protein import into nucleus GO:0006606 IEA:Ensembl regulation of vitamin D receptor signaling pathway GO:0070562 IEA:Ensembl retinal pigment epithelium development GO:0003406 IEA:Ensembl thyroid hormone generation GO:0006590 IEA:Ensembl thyroid hormone mediated signaling pathway GO:0002154 IEA:Ensembl ventricular trabecula myocardium morphogenesis GO:0003222 IEA:Ensembl |
Binary Interactions |
Repeats | >MDP28193 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 7| 323.10| 46| 51| 1075| 1120| 1 --------------------------------------------------------------------------- 791- 826 (37.11/ 6.16) .......SKLPSTS...DDCPP...I..GT.PVRDSSSSGH..S.......QSALFD..PD..VF... 827- 872 (39.75/ 7.17) .......QTNNNENPYTDPADLIADA..AG.SPSSDSPTNHffP.......DGVDFN..PD..LLN.S 967- 1015 (45.19/ 9.25) KT.....QKRVKEGNGTSNSSLSGPGldSKpGKRSRTPSND..S.......KSKDKP..PK..RKK.A 1020- 1068 (43.71/ 8.68) KS....pSHSSSNRPFTP..PTSTGG..SK.SPGSSGRSQT..P.......PGVATPpiPKitIQI.P 1069- 1118 (72.44/19.64) KG.tvmvSKSSSHSQYTSSGSVSSSG..SK.SHHSHSSSSS..S.......SSASTS..GK..MKS.S 1119- 1177 (43.73/ 8.69) KSegsssSKLSS.SMYSSQGSSGSSQ..SKnSSQSGGKPGS..SpitkhglSSGSSS..TK..MKPqG 1428- 1462 (41.17/ 7.71) .............KNY...GSPLISG..ST.PKHERGSPSH..S.......KSPAYT..PQ..NLD.S --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 7| 290.89| 39| 40| 1216| 1254| 2 --------------------------------------------------------------------------- 615- 653 (39.55/10.43) G....STIGSSPT......pphhTPP.......PVSSMAGNtkNHPML.....MNLLKDNP 1216- 1245 (45.78/13.28) .......................TPPSSKAK.SPISSGSGG..SHISG.....TSSSSGMK 1246- 1287 (51.07/15.71) S....SGLGSSGS......lsqkTPPSSNS..CTASSSSFS..SSGSS.....MSSSQNQH 1288- 1340 (32.70/ 7.29) G....SSKGKSPS...rnkkpslTAVIDKLKhGVVTSGPGG.eDQMDGqmgvsTNSSHPMS 1341- 1379 (34.66/ 8.19) SkhnmSGGEFQGK..........REKSDKDK.SKVST.SGG..SVDSS.....KKTSE... 1380- 1425 (36.28/ 8.93) S....KNVGSTGVakiiiskhdgGSPSIKAK.VTLQK.PGE..S..SG.....EGLRPQMA 1508- 1546 (50.85/15.61) D....RDKKKSHS..........IKPENWSK.SPISSDQSL..SLTSN.....TILSADRP --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 61.26| 17| 20| 541| 558| 3 --------------------------------------------------------------------------- 541- 558 (29.44/17.68) PPASSPGYGMTTGNNpMS 563- 579 (31.83/14.19) PTNTFPGGPITTLFN.MS --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 3| 59.91| 13| 21| 890| 902| 4 --------------------------------------------------------------------------- 890- 902 (25.72/15.10) GDNDD..FKGFA.SQA 913- 926 (17.81/ 7.95) GDNGEtkFKG.N.SQA 942- 955 (16.39/ 6.66) GPADI..MEHHSgSQS --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 4| 221.99| 49| 50| 324| 373| 5 --------------------------------------------------------------------------- 272- 322 (41.78/19.88) ........PLiMGSHPVdnkWTPSFSSITsansvdlpaCFFL.KFPQPIPVSRA...F...VQKL...Q.. 324- 373 (89.70/57.28) CTGI....PL.FEAQPT...YVPLYELIT.........QFELSKDPDPIPLNHNM.RF...YAALPGQQhC 375- 424 (49.65/25.48) ..FLnkdaPL.PDGRSL...QGTLVSKIT.........FQH....PGRVPLILNLiRHqvaYNTLIGS..C 434- 462 (40.86/19.26) CPGL....LQ.FEV.......CPLSE..S.........RFSVSFQH...PVNDSL................ --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 102.84| 38| 50| 150| 199| 6 --------------------------------------------------------------------------- 165- 213 (52.04/53.42) GDNKLKTKMYLALQSLEQDlskmaimywKATnaSP...............LDKILHGSVG.YLTP 216- 269 (50.81/32.75) GGHLMNLKYYASPSDLLDD.........KTT..SPiilhenivprslgmnASVTIEGTSAmYKLP --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 100.04| 29| 52| 696| 726| 8 --------------------------------------------------------------------------- 696- 726 (49.63/32.85) PP...DKPKHQTEDDFQRELFSMDVDSQNPifDV 748- 779 (50.41/27.19) PPttyPQPIPHPQPSIQRMVRLSSSDSIGP..DV --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) FGEEYFD 2) IKAKVTLQK 3) IRPLPEYSTEKHKKHKKEKKKD 4) KITIQIPK 5) KPSLTAVIDKLKHGV 6) RLSPDFMIGEEDDDLMDV 7) VAKIIISKH | 878 1403 1485 1062 1300 1548 1388 | 884 1411 1506 1069 1314 1565 1396 |
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Designed by Dr. Shailesh Lab & Dr. Jitendra K. Thakur Lab