<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28192
Description |
Mediator of RNA polymerase II transcription subunit 4 |
Sequence | GDMAASSGAEKEKERPGGGSGAAGGNSTRERLLSALEDLEVLSRELIEMLAISRNQKLLQAEEENQILELLIHRDGEFQDLMKLALNQGKIHHEMQVLEKEVEKRDSDIQQLQKQLKEAEQILATAVYQAKEKLKSIEKARKGAISSEEIIKYAHRISASNAVCAPLTWVPGDPRRPYPTDLEMRSGLLGQMNNPSTNGVNGHLPGDALAAGRLPDVLAPQYPWQSNDMSMNMLPPNHSNDFLLEPPGHNKENEDDVEVMSTDSSSSSSDSD |
Length | 272 |
Position | Middle |
Organism | Loxodonta africana (African elephant) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia>
Eutheria> Afrotheria> Proboscidea> Elephantidae> Loxodonta.
|
Aromaticity | 0.03 |
Grand average of hydropathy | -0.688 |
Instability index | 50.16 |
Isoelectric point | 4.91 |
Molecular weight | 29902.09 |
Publications | |
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364141
|
GO - Cellular Component | mediator complex GO:0016592 IEA:Ensembl
nucleoplasm GO:0005654 IEA:Ensembl
|
GO - Biological Function | thyroid hormone receptor binding GO:0046966 IEA:Ensembl
transcription coactivator activity GO:0003713 IEA:Ensembl
|
GO - Biological Process | positive regulation of transcription initiation from RNA polymerase II promoter GO:0060261 IEA:Ensembl
transcription by RNA polymerase II GO:0006366 IEA:Ensembl
|
Interaction
Repeat regions
Repeats |
>MDP28192
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 67.92| 25| 29| 30| 56| 1
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32- 56 (40.19/30.00) LLSALED...LEVL.SR..ELIEMLAISRNQ
58- 88 (27.74/12.50) LLQAEEEnqiLELLiHRdgEFQDLMKLALNQ
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 68.55| 25| 27| 96| 122| 2
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96- 122 (30.31/25.09) QVLEKEvEKRDSdIQQLQKQLKEAEQI
126- 150 (38.24/21.92) AVYQAK.EKLKS.IEKARKGAISSEEI
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