<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28191

Description Uncharacterized protein
SequenceEQDELTAVNVKQGFNNQPAFTGDEHGSARNIVINPSKIGAYFSSILAEKLKLNTFQDTGKKKPQVNAKDNYWLVTARSQSVIHSWFSDLAGNKPLAILAKKVPILSKKEDVFAYLAKYSVPMVRATWLIKMTCAYYSAISEAKIKKRQATDPNLDAEWTQISTRYLREQLAKISDFYHMASSTGDGPAPVPPDVEQAMRQWEYNEKLAFHMFQEGMLEKHEYLTWILDVLEKIRPMDDDLLKLLLPLMLQYSDEFVQSAYLSRRLAYFCARRLSLLLSDSPNLLTAHSPHVMIGPNTSSIGAPSPGPPGPGMSPVQLAFSDFLSCAQHGPLVYGLSCMLQTVTLCCPSALVWNYSTNENKSANPGSPLDLLQVAPSSLPMPGGNTAFNQQVRARIYEVERQIKQRGRAVEVRWSFDKCQESTAGVTISRVLHTLEVLDRHCFDRTDSSNSMETLYHKIFWPNQNKDNQEVAPNDEAVVTLLCEWAVSCKRSGKHRAMAVAKLLEKRQAEIEAERCGESEVLDEKESISSASLAGSSLPVFQNVLLRFLDTQAPSLSDPNSECEKVEFVNLVLLFCEFIRHDVFSHDAYMCTLISRGDLSVTASTRPRSPAGENVDEHYSKDHDAKMEIFSPMPGESCENANPALGRRMSVNGEKLMKREKPRELIFPSNYGLLRHLQYATHFPVPLDESSSHECNQRTILLYGVGKEREEARHQLKKITKDILKTLNKKSTAETGGVDEGQKARKNKQEAFPTLETVFTKLQLLSYFDQHQVTSQISNNVLEQITSFASGTSYHLPLAHHVQLIFDLMEPALNINGLIDFAIQLLNELSVVEAELLLKSSSLAGSYTTGLCVCIVAVLRRYHSCLILNPDQTAQVFEGLCGVVKHVVNPSECSSPERCILAYLYDLYVSCSHLRSKFGDLFSSACSKVKQTIYNNVMPANSNLRWDPDFMMDFIANPSARSINYSMLGKILSDNAASRYSFVCNTLMNVCMGHQDAGRINDIANFSSELTACCTVLSSEWLGVLKALCCSSNHVWGFNDVLCTVDVSDLSFHDSLATFIAILIARQCFSLEDVVQHVALPSLLAAACGDADAEPGARMTCRLLLHLFRAPQACLLPQASGKPFPGIRSSCDRHLLAAAHNSIEVGAVFAVLKAIMMLGDAKIGNNNVSSLKNDDFTVRGLRRDGNADDIWTASQNSKSCGKSISIETANLREYARHVLRTICQQEWVGEHCLKEPERLCTDKELILDPVLSNIQAQKLLQLICYPHGIKECTEGDNLQRQHIKRILQNLEQWTLRQSWLELQLMIKQCLKDPGSGSVAEMNNLLDNIAKATIEVFQQSADLNNNSSSSGMGLFTPNSIGSTDASSTRQNGIKTFLSSSERRGVWLVAPLIARLPTSVQGRVLKAAGEELEKGQHLGSSSKKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLQNQVNQILSNWREERYQDDIKARQMMHEALQLRLNLVGGMFDTVQRSTQWTTDWALLLLQIITSGTVDMHTNNELFTTVLDMLGVLINGTLASDLSTASPGGSEENKRAYMNLVKKLKKELGDKRSESIDKVRQLLPLPKQTCDVITCEPMGSLIDTKGNKIAGFDSIDKKQARGLQVSAKQKVSPWDLFEGQKNPAPLSWAWFGTVRVDRKVIKYEEQHHLLLYHTHPMPKPRSYYLEPLPLPPEEEEEEPTSPVSQEPDRKSAELSDQGKTAMDEEKKTKGRKRKTKSSSRVDEYPQSNMYRVPPNYSPISSQMMHHPQSTLWGYNLMGQPQQPSFFLQNQSLTPGGSRLDPAGAFVPTNTKQALSNMLQRRSGAMLQPPSLHAITSQQQLIQMKLLQQQQQQRLLRQAQTRPFQQGQPGDQTALFAAQARPSPQLPQYPGLQLAQTMPQGYTMYGTQMPLQQAPQQQAGSVVLSPSYNSRTYPAAHSNPALMERLRQMQQPPSGYVQQQATPYLQSLTGSQRLNHQTLQQSPLVSGGVDAVLTSAHPNLPSVPLPQDPMRPRQAQVRQQQRLLQVWARAMRRVQGEPDGEQSSQPQGQTLGLQAMQPQQPLFPRQGLQQTQQQQQTAALVRQLQKQLSSNQPQQGVTPYGHPSHF
Length2119
PositionKinase
OrganismLoxodonta africana (African elephant)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Afrotheria> Proboscidea> Elephantidae> Loxodonta.
Aromaticity0.07
Grand average of hydropathy-0.407
Instability index56.39
Isoelectric point8.01
Molecular weight236624.94
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP28191
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     632.20|     158|     160|    1759|    1918|       1
---------------------------------------------------------------------------
 1595- 1736 (155.44/81.34)	........................................QLLPLPKQTCDVI.........TCEPMGSLIDTKGnkiaGFDSIDKKQARG..LQvsakqkvspwdlfegQKNP...APLSW..AWFGTVRVDRKVIKYEeqhhlLLYHTHPMPKP.......RSYYLEP..LP..LPPEEE.....EEEPTSPVSQEP..DRKSAELSDQGKTAM
 1759- 1918 (283.77/160.15)	PQSNMYRVP..........PNYSPISSQMMHHPQSTLWGYNLMGQPQQPSFFLQN......QSLTPGGSRLDPAG....AFVPTNTKQALSNMLQ...............RRSG...AMLQP..PSLHAITSQQQLIQMK.....LLQQQQQQRLL.......RQAQTRP..FQQGQPGDQTalFAAQARPSPQLPQYP..GLQLAQTMPQGYTMY
 1920- 2089 (192.98/103.07)	TQMPLQQAPqqqagsvvlsPSYNSRTYPAAHSNPALMERLRQMQQP..PSGYVQQqatpylQSLT.GSQRLNHQT..........LQQ..SPLV..................SGgvdAVLTSahPNLPSVPLPQDPMRPR.....QAQVRQQQRLLqvwaramRRVQGEPdgEQSSQPQGQT..LGLQA.MQPQQPLFPrqGLQQTQQQQQ.....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     232.03|      72|     154|    1157|    1240|       2
---------------------------------------------------------------------------
  967- 1043 (120.94/79.42)	LG..KILSDNAASrysfVCNTLMNVcMGHQDAGRINDIANFSSELTACCTVLSSEWLG.......VLKALCCS...SNHVWGFNDVLCT
 1157- 1240 (111.09/102.48)	LGdaKIGNNNVSS....LKNDDFTV.RGLRRDGNADDIWTASQNSKSCGKSISIETANlreyarhVLRTICQQewvGEHCLKEPERLCT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     105.71|      34|     155|      14|      57|       3
---------------------------------------------------------------------------
   14-   57 (45.70/58.08)	FNNQPAFTGDehGSArniVINPSKIGA.....YfssilAEKLKLNTFQD
  176-  214 (60.01/41.38)	FYHMASSTGD..GPA...PVPPDVEQAmrqweY.....NEKLAFHMFQE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.55|      20|      23|    1511|    1532|      10
---------------------------------------------------------------------------
 1511- 1532 (31.18/27.74)	WTTdwALLLLQIITSGTV..DMHT
 1537- 1558 (29.36/17.29)	FTT..VLDMLGVLINGTLasDLST
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     199.10|      50|     252|     844|     893|      11
---------------------------------------------------------------------------
  792-  842 (62.90/42.57)	.SYHLPLAHHVQLIF.DLMEPALNINGliDFAIQLLNELSVVEAELLLKSSSL
  844-  893 (87.17/62.37)	GSYTTGLCVCIVAVL.RRYHSCLILNP..DQTAQVFEGLCGVVKHVVNPSECS
  895-  932 (49.02/31.25)	PE......RCILAYLyDLYVSCSHLRS...KFGDLFSSACSKVKQTI......
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28191 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) QPSFFLQNQSLTPGGSRLDPAGAFVPTNTKQALSNMLQRRSGAMLQPPSLHA
2) QQQRLLRQAQTRPFQQGQPGDQTALFAAQARPSPQLPQYPGLQL
3) RSYYLEPLPLPPEEEEEEPTSPVSQEPDRKSAELSDQGKTAMDEEKKTKGRKRKTKSSSRVDEYPQSNMYRVPPNYSPISSQMMHHPQSTLWGYNLMGQP
4) TMYGTQMPLQQAPQQQAGSVVLSPSYNSRTYPAAHSNPALMERLRQMQQPPSGYVQQQATPYLQSLTGSQRLNHQTLQQSPLVSGGVDAVLTSAHPNLPSVPLPQDPMRPRQAQVRQQQR
5) WARAMRRVQGEPDGEQSSQPQGQTLGLQAMQPQQPLFPRQGLQQTQQQQQTAALVRQLQKQLSSNQPQQGVTPYGHPSHF
1796
1864
1695
1916
2040
1847
1907
1794
2035
2119










Molecular Recognition Features






MoRF SequenceStartStop




1) YYLEPL
1697
1702