<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28188

Description Mediator complex subunit 25
SequenceMVPGSEGPARAGSVVADVVFVIEGTANLGPYFEGLRKHYLLPAIEYFNGGPPAETDFGGDYGGTQYSLVVFNTVDCAPESYVQCHAPTSSAYEFVTWLDGIKFMGGGGESCSLIAEGLSTALQLFDDFKKMREQIGQTHRVCLLICNSPPYLLPAVESTTYSGCTTENLVQQIGERGIHFSIVSPRKLPALRLLFEKAAPPALLEPLQPLTDVSQDPRHMVLVRGLVLPVGGGSAPGPLQSKQPVPLPPAAPSGAALSAAPQQPLPPVPPQYQVPGNLSAAQVAAQNAVEAAKNQKAGLGPRFSPITPLQQAAPGVGPPFSQAPAPQLPPGPPGAPKPPPASQPSLVSTVAPGSGLAPTAQPGAPSMAGTVAPGGVSGPSPAQLGAPALGGQQSVSNKLLAWSGVLEWQEKPKPASVDANTKLTRSLPCQVYVNHGENLKTEQWPQKLIMQLIPQQLLTTLGPLFRNSRMVQFHFTNKDLESLKGLYRIMGNGFAGCVHFPHTAPCEVRVLMLLYSSKKKIFMGLIPYDQSGFVNGIRQVITNHKQVQQQKLEQQQRGMGGQQAPPGLGPILEDQARPSQNLLQLRPPQPQPQGTVGASGATGQPQPQGTAQPPPGAPQGPPGAASGPPPPGPILRPQNPGANPQLRSLLLNPPPPQTGVPPPQASLHHLQPPGAPALLPPPHQGLGQPQLGPPLLHPPPAQSWPAQLPPRAPLPGQMLLSGGPRGPVPQPGLQPSVMEDDILMDLI
Length747
PositionUnknown
OrganismGorilla gorilla gorilla (Western lowland gorilla)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini> Hominidae> Gorilla.
Aromaticity0.05
Grand average of hydropathy-0.238
Instability index60.25
Isoelectric point8.61
Molecular weight78155.81
Publications
PubMed=22398555

Function

Annotated function 
ECO:0000256	RuleBase:RU364144
GO - Cellular Component
mediator complex	GO:0016592	IBA:GO_Central
nucleoplasm	GO:0005654	IEA:Ensembl
transcription regulator complex	GO:0005667	IBA:GO_Central
GO - Biological Function
GO - Biological Process
positive regulation of transcription by RNA polymerase II	GO:0045944	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats
>MDP28188
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     372.41|      48|      60|     614|     661|       1
---------------------------------------------------------------------------
  238-  275 (49.01/ 8.38)	PLQSKQPVPLPPAAPSGAalSAAP..Q......QPLPP...VP...P....Q...YQvP
  311-  340 (57.34/11.38)	QAAPGVGPP....FSQAP..A..P..Q.....L.PPG.........PPGAPK...PP.P
  560-  596 (50.13/ 8.78)	GGQQAPPGLGPILEDQAR..PSQNllQLRP................PQPQPQ...GT.V
  597-  622 (51.05/ 9.11)	GAS.................GATG..Q.......PQPQGTAQP...PPGAPQ...GP.P
  623-  673 (94.51/24.81)	GAASGPPPPGPILRPQNP..GANP..QLRSLLLNPPPPQTGVP...PPQASLhhlQP.P
  674-  715 (70.37/16.09)	GAPALLPPP.....HQGL..G.QP..QLGPPLLHPPPAQ.SWPaqlPPRAPL......P
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     108.82|      31|     110|      39|      69|       2
---------------------------------------------------------------------------
   39-   69 (58.34/29.37)	YLLPAIEYFNGGPPAETDFGGDYG..GTQYSLV
  151-  183 (50.47/24.50)	YLLPAVESTTYSGCTTENLVQQIGerGIHFSIV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.62|      19|      20|     350|     369|       3
---------------------------------------------------------------------------
  350-  369 (34.03/14.64)	VAPG..SGLAPtAQPGAPSMAG
  371-  391 (31.59/10.05)	VAPGgvSGPSP.AQLGAPALGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.62|      22|      25|     464|     487|       4
---------------------------------------------------------------------------
  464-  487 (34.11/30.68)	LFrnSRMVQF.HFTNKDLESLKGLY
  493-  515 (37.50/26.08)	GF..AGCVHFpHTAPCEVRVLMLLY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.71|      15|      23|     422|     436|       7
---------------------------------------------------------------------------
  422-  436 (28.29/21.94)	KLTRSL.PCQVYVNHG
  447-  462 (21.42/14.27)	KLIMQLiPQQLLTTLG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28188 with Med25 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GSAPGPLQSKQPVPLPPAAPSGAALSAAPQQPLPPVPPQYQVPGNLSAAQVAAQNAVEAAKNQKAGLGPRFSPITPLQQAAPGVGPPFSQAPAPQLPPGPPGAPKPPPASQPSLVSTVAPGSGLAPTAQPGAPSMAGTVAPGGVSGPSPAQLGAPALG
2) HKQVQQQKLEQQQRGMGGQQAPPGLGPILEDQARPSQNLLQLRPPQPQPQGTVGASGATGQPQPQGTAQPPPGAPQGPPGAASGPPPPGPILRPQNPGANPQLRSLLLNPPPPQTGVPPPQASLHHLQPPGAPALLPPPHQGLGQPQLGPPLLHPPPAQSWPAQLPPRAPLPGQMLLSGGPRGPVPQPGLQPSVMEDDILMD
233
544
390
745










Molecular Recognition Features






MoRF SequenceStartStop




1) LMDLI
743
747