Description | Mediator of RNA polymerase II transcription subunit 1 |
Sequence | MKAQGETEESEKLSKMSSLLERLHAKFNQNRPWSETIKLVRQVMEKRVVMSSGGHQHLVSCLETLQKALKVTSLPAMTDRLESIARQNGLGSHLSASGTECYITSDMFYVEVQLDPAGQLCDVKVAHHGENPVSCPELVQQLREKNFDEFSKHLKGLVNLYNLPGDNKLKTKMYLALQSLEQDLSKMYYVSPSDLLDDKTASPIILHENNVSRSLGMNASVTIEGTSAVYKLPIAPLIMGSHPVDNKWTPSFSSITSANSVDLPACFFLKFPQPIPVSRAFVQKLQNCTGIPLFETQPTYAPLYELITQFELSKDPDPIPLNHNMRFYAALPGQQHCYFLNKDAPLPDGRSLQGTLVSKITFQHPGRVPLILNLIRHQVAYNTLIGSCVKRTILKEGTAFPLICLLEDGNLLLQWSHSAAIAMLTLFSSLFCRCMSIPVTMRAIRRKAETIQADTPALSLIAETVEDMVKKNLPPASSPGYGMTTGNNPMSGTTTPTNTFPGGPITTLFNMSMSIKDRHESVGHGEDFSKVSQNPILTSLLQITGNGGSTIGSSPTPPHHTPPPVSSMAGNTKNHPMLMNLLKDNPAQDFSTLYGSSPLERQNSSSGSPRMEICSGSNKTKKKKSSRLPPEKPKHQTEDDFQRELFSMDVDSQNPIFDVNMTADTLDTPHITPAPSQCSTPPTTYPQPVPHPQPSIQRMVRLSSSDSIGPDVTDILSDIAEEASKLPSTSDDCPAIGTPLRDSSSSGHSQSTLFDSDVFQTNNNENPYTDPADLIADAAGSPSSDSPTNHFFHDGVDFNPDLLNSQSQSGFGEEYFDESSQSGDNDDFKGFASQALNTLGVPMLGGDNGETKFKGNNQADTVDFSIISVAGKALAPADLMEHHSGSQGPLLTTGDLGKEKTQKRVKEGNGTSNSTLSGPGLDSKPGKRSRTPSNDGKSKDKPPKRKKADTEGKSPSHSSSNRPFTPPTSTGGSKSPGSSGRSQTPPGVATPPIPKITIQIPKGTVMVGKPSSHSQYTSSGSVSSSGSKSHHSHSSSSSSSASTSGKMKSSKSEGSSSSKLSSSMYSSQGSSGSSQSKNSSQSGGKPGSSPVTKHGLSSGSSSTKMKPQGKPSSLMNPSLSKPNISPSHSRPPGGSDKLASPMKPVPGTPPSSKAKSPISSGSGGSHMSGTSSSSGMKSSSGLGSSGSLSQKTPPSSNSCTASSSSFSSSGSSMSSSQNQHGSSKGKSPSRNKKPSLTAVIDKLKHGVVTSGPGGEDPLDGQMGVSTNSSSHPMSSKHNMSGGEFQGKREKSDKDKSKVSTSGSSVDSSKKTSESKNVGSTGVAKIIISKHDGGSPSIKAKVTLQKPGESSGEGLRPQMASSKNYGSPLISGSTPKHERGSPSHSKSPAYTPQNLDSESESGSSIAEKSYQNSPSSDDGIRPLPEYSTEKHKKHKKEKKKVKDKDRDRDRDKDRDKKKSHSIKPESWSKSPISSDQSLSMTSNTILSADRPSRLSPDFMIGEEDDDLMDVALIGN |
Length | 1514 |
Position | Middle |
Organism | Gorilla gorilla gorilla (Western lowland gorilla) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini> Hominidae> Gorilla. |
Aromaticity | 0.04 |
Grand average of hydropathy | -0.692 |
Instability index | 54.40 |
Isoelectric point | 8.93 |
Molecular weight | 161119.83 |
Publications | PubMed=22398555 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364059 |
GO - Cellular Component | mediator complex GO:0016592 IBA:GO_Central nucleolus GO:0005730 IEA:Ensembl nucleoplasm GO:0005654 IEA:Ensembl |
GO - Biological Function | DNA binding GO:0003677 IEA:Ensembl estrogen receptor binding GO:0030331 IEA:Ensembl LBD domain binding GO:0050693 IEA:Ensembl nuclear receptor coactivator activity GO:0030374 IEA:Ensembl peroxisome proliferator activated receptor binding GO:0042975 IEA:Ensembl promoter-specific chromatin binding GO:1990841 IEA:Ensembl protein-containing complex binding GO:0044877 IEA:Ensembl retinoic acid receptor binding GO:0042974 IBA:GO_Central thyroid hormone receptor binding GO:0046966 IBA:GO_Central transcription coregulator activity GO:0003712 IBA:GO_Central transcription corepressor activity GO:0003714 IEA:Ensembl vitamin D receptor binding GO:0042809 IBA:GO_Central |
GO - Biological Process | androgen biosynthetic process GO:0006702 IEA:Ensembl angiogenesis GO:0001525 IEA:Ensembl animal organ regeneration GO:0031100 IEA:Ensembl brain development GO:0007420 IEA:Ensembl cell morphogenesis GO:0000902 IEA:Ensembl cellular response to epidermal growth factor stimulus GO:0071364 IEA:Ensembl cellular response to hepatocyte growth factor stimulus GO:0035729 IEA:Ensembl cellular response to thyroid hormone stimulus GO:0097067 IBA:GO_Central embryonic heart tube development GO:0035050 IEA:Ensembl embryonic hemopoiesis GO:0035162 IEA:Ensembl embryonic hindlimb morphogenesis GO:0035116 IEA:Ensembl embryonic placenta development GO:0001892 IEA:Ensembl enucleate erythrocyte development GO:0048822 IEA:Ensembl epithelial cell proliferation involved in mammary gland duct elongation GO:0060750 IEA:Ensembl fat cell differentiation GO:0045444 IEA:Ensembl intracellular steroid hormone receptor signaling pathway GO:0030518 IEA:Ensembl keratinocyte differentiation GO:0030216 IEA:Ensembl lactation GO:0007595 IEA:Ensembl lens development in camera-type eye GO:0002088 IEA:Ensembl liver development GO:0001889 IEA:Ensembl mammary gland branching involved in pregnancy GO:0060745 IEA:Ensembl mammary gland branching involved in thelarche GO:0060744 IEA:Ensembl megakaryocyte development GO:0035855 IEA:Ensembl monocyte differentiation GO:0030224 IEA:Ensembl mRNA transcription by RNA polymerase II GO:0042789 IEA:Ensembl negative regulation of apoptotic process GO:0043066 IEA:Ensembl negative regulation of keratinocyte proliferation GO:0010839 IEA:Ensembl negative regulation of neuron differentiation GO:0045665 IEA:Ensembl negative regulation of transcription by RNA polymerase II GO:0000122 IEA:Ensembl peroxisome proliferator activated receptor signaling pathway GO:0035357 IEA:Ensembl positive regulation of erythrocyte differentiation GO:0045648 IEA:Ensembl positive regulation of G0 to G1 transition GO:0070318 IEA:Ensembl positive regulation of gene expression GO:0010628 IEA:Ensembl positive regulation of hepatocyte proliferation GO:2000347 IEA:Ensembl positive regulation of interferon-gamma-mediated signaling pathway GO:0060335 IEA:Ensembl positive regulation of intracellular estrogen receptor signaling pathway GO:0033148 IEA:Ensembl positive regulation of keratinocyte differentiation GO:0045618 IEA:Ensembl positive regulation of transcription initiation from RNA polymerase II promoter GO:0060261 IEA:Ensembl protein import into nucleus GO:0006606 IEA:Ensembl regulation of transcription by RNA polymerase II GO:0006357 IBA:GO_Central regulation of vitamin D receptor signaling pathway GO:0070562 IEA:Ensembl retinal pigment epithelium development GO:0003406 IEA:Ensembl thyroid hormone generation GO:0006590 IEA:Ensembl thyroid hormone mediated signaling pathway GO:0002154 IEA:Ensembl ventricular trabecula myocardium morphogenesis GO:0003222 IEA:Ensembl |
Binary Interactions |
Repeats | >MDP28184 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 7| 1090.14| 164| 164| 896| 1059| 1 --------------------------------------------------------------------------- 445- 573 (82.25/13.76) ........................................................................RRKAETiQAD......TPALSliaetveDMVK......KN....LPPAS.....SP.GY........GMTTGNN.PmsGTTTPtntfPGGPITtlfnmsMSIKDRHE...SVGHGEDFSkvsqnpiltsllQI.......T..GNGgsTIGSSPTPP........HHTPPPV.....SSM...AGNT.................K 581- 746 (181.75/38.21) LLKD.NPAQDF..STLYGSSplerqNSSSGS..PR....MEICS....GS.NKTKKK..KSSRLP.....PEKPKHQT.EDDfqrelfSMDVD.......SQNP......IFdvnmTADTLDTPHITP.AP........S.QCSTP.P..TTYPQ....PVPH...........PQPSI.qrMVRLSSSDS............IG.......P..DVT..DILSDIAEE........ASKLPST.....SDD...CPAIGT.PLRDS.....SSS.. 747- 895 (119.45/22.90) .................GHS.....QSTL..........FDS.......DVFQTNNNENPYTD.......PADLIADA.AGS......PSSDS.......PTNHffhdgvDF....NPDLLNSQSQSGfGEeyfdessqSGDNDDF.K..GFASQ....ALN..T......LGVP.......MLGGDNGET............KFkgnnqadT..VDF..SIISVAGKAlapadlmeHHSGSQ.................G.PL........LTTGD 896- 1059 (282.70/63.01) LGKE.KTQKRV..KEGNGTS.....NSTLSG..PG....LDSKP....GKRSRTPSNDGKSKDKP.....PKRKKADT.EGK......SPSHS.......SSNR......PF....TPPTSTGGSKSP.GS........SGRSQTP.P..GVATP....PIPKIT......IQIPKGTV...MVGKPSSHS............QY.......T..SSG..SVSSSGSKS........HHSHSSS.....SSS...SASTSG.KMKSSKSE.GSSSSK 1060- 1226 (180.73/37.96) LSSS.MYSSQG..SSGSSQS....kNSSQSGgkPG......SSPvtkhGLSSGSSSTKMKPQGKPsslmnPSLSKPNI..........SPSHS..........R......P.......P...GGSDKL.AS........PMK...PvP..G..TP....PSSKAK......SPISSGSGgshMSGTSSS.S............GM.......K..SSS..GLGSSGSLS........QKTPPSSnsctaSSS...SFSSSGsSMSSSQNQhGSSKGK 1230- 1388 (179.41/37.63) RNKK.PSLTAVidKLKHGV........VTSG..PGgedpLDGQM....GVSTNSSSHPMSSKH........NMSGGEF.QGK......R.EKS.......DKDK.............SKVSTSGS.SV.DS........SKKTSES.K..NVGST....GVAKII......ISKHDG.......GSPSIKA............KV.......TlqKPG..ESSGEGLRP........QMASSKN.....YGSpliSGSTPK.HERGSPSH..SKSPA 1394- 1476 (63.85/ 9.24) LDSEsESGSSI..AE.KSYQ.....NSPSSD..DG....IRPLPeystEKHKKHKKEKKKVKDKD.....RDRDRDKD.RDK......KKSHS..................I....KPE.S..WSKSP.IS........SDQS...................................................................................................................................... --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 3| 165.03| 45| 68| 263| 307| 2 --------------------------------------------------------------------------- 199- 238 (42.02/24.39) ......................KTASPIILHEN....NVSRsL..GMNASVT....IEGTSAVYKlPIAPLI 263- 307 (82.38/56.02) LP...............ACFFLKFPQPIPVSRA....FVQK.L..QNCTGIP....LFETQPTYA.PLYELI 319- 384 (40.62/23.30) IPlnhnmrfyaalpgqqHCYFLNKDAPLPDGRSlqgtLVSK.ItfQHPGRVPlilnLIRHQVAYN.TL.... --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) FGEEYF 2) IRPLPEYSTEKHKKHKKEKKKVKDKDRDRD 3) ITIQIPK 4) KPSLTAVIDKLKHGV 5) RLSPDFMIGEEDDDLMDV 6) SIKAKVTLQK 7) VAKIIISKH | 811 1419 996 1233 1492 1336 1322 | 816 1448 1002 1247 1509 1345 1330 |
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