<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28168

Description Mediator of RNA polymerase II transcription subunit 13
SequenceGGAGASMPSLSAPPSKNLHFLFIWMSFLLVLFFSFFFFFSVVEEGLWENGLSYECRTLLFKAIHNLLERCLMDKNFVRIGKWFVRPYEKDEKPVNKSEHLSCAFTFFLHGESNVCTSVEIAQHQPIYLINEEHIHMAQSSPAPFQVLVSPYGLNGTLTGQAYKMSDPATRKLIEEWQYFYPMVLKKKEESKEEDELGYDDDFPVAVEVIVGGVRMVYPSAFVLISQNDIPVPQSAASAGGHIAVGQQGLGSVKDPSNCGMPLTPPTSPEQAILGESGGMQSAASHLVSQDGGMITMHSPKRSGKIPPKLHNHMVHRVWKECILNRTQSKRSQMSTPTLEEEPASNPATWDFVDPTQRVSCSCSRHKLLKRCAVGPNRPPTVSQPGFSAGPSSSSSLPPPASSKHKTTERQEKGDKLQKRPLIPFHHRPSVAEELCMEQDTPGQKLGLAGIDSSLEVSSSRKYDKQMAVPSRNTSKQMNLNPMDSPHSPISPLPPTLSPQPRGQETESLDPPPVPVNPALYGNGLELQQLSTLDDRTVLVGQRLPLMAEVSETALYCGIRPSNPESSEKWWHSYRLPPSDDAEFRPPELQGERCDAKMEVNSESTALQRLLAQPNKRFKIWQDKQPQMQPLHFLDPLPLSQQPGDSLGEVNDPYTFEDGDIKYIFTANKKCKQGTEKDSLKKNKSEDGFGTKDVTTPGHSTPVPDGKNAMSIFSSATKTDVRQDNAAGRAGSSSLTQVTDLAPSLHDLDNIFDNSDDDELGAVSPALRSSKMPAVGTEDRPLGKDGRAAVPYPPTVADLQRMFPTPPSLEQHPAFSPVMNYKDGISSETVTALGMMESPMVSMVSTQLTEFKMEVEDGLGSPKPEEIKDFSYVHKVPSFQPFVGSSMFAPLKMLPSHCLLPLKIPDACLFRPSWAIPPKIEQLPMPPAATFIRDGYNNVPSVGSLADPDYLNTPQMNTPVTLNSTAPASNSGAGVLPSPATPRFSVPTPRTPRTPRTPRGGGTASGQGSVKYDSTDQGSPASTPSTTRPLNSVEPATMQPIPEAHSLYVTLILSDSVMNIFKDRNFDSCCICACNMNIKGADVGLYIPDSSNEDQYRCTCGFSAIMNRKLGYNSGLFLEDELDIFGKNSDIGQAAERRLMMCQSTFLPQVEGTKKPQEPPISLLLLLQNQHTQPFASLNFLDYISSNNRQTLPCVSWSYDRVQADNNDYWTECFNALEQGRQYVDNPTGGKVDEALVRSATVHSWPHSNVLDISMLSSQDVVRMLLSLQPFLQDAIQKKRTGRTWENIQHVQGPLTWQQFHKMAGRGTYGSEESPEPLPIPTLLVGYDKDFLTISPFSLPFWERLLLDPYGGHRDVAYIVVCPENEALLEGAKTFFRDLSAVYEMCRLGQHKPICKVLRDGIMRVGKTVAQKLTDELVSEWFNQPWSGEENDNHSRLKLYAQVCRHHLAPYLATLQLDSSLLIPPKYQTPPAAAQGQATPGNAGPLAPNGSAAPPAGSAFNPTSNSSSTNPAASSSASGSSVPPVSSSASAPGISQISTTSSSGFSGSVGGQNPSTGGISADRTQGNIGCGGDTDPGQSSSQPSQDGQESVTERERIGIPTEPDSADSHAHPPAVVIYMVDPFTYAAEEDSTSGNFWLLSLMRCYTEMLDNLPEHMRNSFILQIVPCQYMLQTMKDEQVFYIQYLKSMAFSVYCQCRRPLPTQIHIKSLTGFGPAASIEMTLKNPERPSPIQLYSPPFILAPIKDKQTELGETFGEASQKYNVLFVGYCLSHDQRWLLASCTDLHGELLETCVVNIALPNRSRRSKVSARKIGLQKLWEWCIGIVQMTSLPWRVVIGRLGRLGHGELKDWSILLGECSLQTISKKLKDVCRMCGISAADSPSILSACLVAMEPQGSFVVMPDAVTMGSVFGRSTALNMQSSQLNTPQDASCTHILVFPTSSTIQVAPANYPNEDGFSPNNDDMFVDLPFPDDMDNDIGILMTGNLHSSPNSSPVPSPGSPSGIGVGSHFQHSRSQGERLLSREAPEELKQQPLALGYFVSTAKAENLPQWFWSSCPQAQNQCPLFLKASLHHHISVAQTDELLPARNSQRVPHPLDSKTTSDVLRFVLEQYNALSWLTCNPATQDRTSCLPVHFVVLTQLYNAIMNIL
Length2147
PositionMiddle
OrganismGorilla gorilla gorilla (Western lowland gorilla)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini> Hominidae> Gorilla.
Aromaticity0.07
Grand average of hydropathy-0.377
Instability index59.08
Isoelectric point5.73
Molecular weight235520.01
Publications
PubMed=22398555

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
integral component of membrane	GO:0016021	IEA:UniProtKB-KW
mediator complex	GO:0016592	IBA:GO_Central

GO - Biological Function
transcription coregulator activity	GO:0003712	IBA:GO_Central

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP28168
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     428.28|     105|     112|     295|     399|       1
---------------------------------------------------------------------------
  258-  342 (100.56/40.79)	...............................CGM.PLTPPTS...P.EQailGESGGMQSAASHLVS...qdggmiTMHSPKRSGKIP..PKL.HNHMVHRVWKE.CILNRTQSKRSQMS..TP.TLEEEP
  343-  455 (146.98/63.33)	ASNPATWD..FVDPTQRVSCSCSRHKL.LKRCAVGPNRPPTV...S.QP...GFSAGPSSSSSLPPP...asskhkTTERQEKGDKLQkrPLI.PFHHRPSVAEElCMEQDTPGQKLGLAgiDS.SLE...
  456-  512 (49.95/16.22)	VSSSRKYDkqMAVPSRNTSKQMNLNPMdSPHSPISP.LPPTL...SpQP......RGQETESLDPPP................................................................
  556-  642 (83.78/32.65)	...............................CGIRPS.NPES...S.EKwwhSYRLPPSDDAEFRPPelqgercdaKMEVNSESTALQ..RLLaQPNKRFKIWQD....KQPQMQPLHFL..DPlPLSQQP
 1491- 1542 (47.02/14.80)	AAPPAGSA..F.NPTSNSS...STNPA.ASSSASGSSVPPVSssaS.AP...GISQISTTSSS....................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.33|      24|      28|    1543|    1568|       2
---------------------------------------------------------------------------
 1545- 1568 (42.92/28.27)	SGSVG.GQN...PSTGGISADRTQGNIG
 1570- 1597 (33.42/13.64)	GGDTDpGQSssqPSQDGQESVTERERIG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     220.41|      66|     898|    1146|    1216|       3
---------------------------------------------------------------------------
 1146- 1216 (108.90/77.87)	LPQVEGTKKPQ.EPPISLLLLLQNQHTQPFASLNFLdyISSNNRQTLPcvsWSYD.RVQADNNDYWTECFNAL
 2046- 2113 (111.51/65.69)	LPQWFWSSCPQaQNQCPLFLKASLHHHISVAQTDEL..LPARNSQRVP...HPLDsKTTSDVLRFVLEQYNAL
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     198.91|      48|      69|     911|     967|       4
---------------------------------------------------------------------------
  911-  958 (90.55/33.43)	PSWAIP.PKIEQLPMPPAATFIRDGYNNVPSVGSLADPDYLNTPQMNTP
  981- 1028 (77.60/34.37)	PRFSVPtPRTPRTPRTPRGGGTASGQGSV.KYDSTDQGSPASTPSTTRP
 1462- 1486 (30.76/ 6.03)	....IP.PKYQ...TPPAAA...QGQATPGNAGPLA.............
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     168.44|      49|     136|     647|     697|       5
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  647-  697 (80.99/56.17)	GEVNDPYTFEDGDIKYIFTANKKCKQGTEKDSLKKNKseDGFGTKDVTTPG
  785-  833 (87.45/55.01)	GRAAVPYPPTVADLQRMFPTPPSLEQHPAFSPVMNYK..DGISSETVTALG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.37|      18|      28|    1956|    1978|       6
---------------------------------------------------------------------------
 1956- 1978 (25.52/20.34)	SPNNDdmfvDLPFPDDmDNDIGI
 1987- 2004 (34.86/13.72)	SPNSS....PVPSPGS.PSGIGV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     222.88|      68|    1266|     100|     172|       7
---------------------------------------------------------------------------
  100-  172 (108.34/91.48)	LSCAFTFFlHGESNVCTSVEIAQHQPIYLINEEHIHMAQSSPAP..FQVLVSPYgLNGTLTGQAykmSDPATR.KL
 1368- 1438 (114.54/77.87)	LEGAKTFF.RDLSAVYEMCRLGQHKPICKVLRDGIMRVGKTVAQklTDELVSEW.FNQPWSGEE...NDNHSRlKL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.10|      23|      27|    1677|    1703|       8
---------------------------------------------------------------------------
 1681- 1703 (43.93/34.10)	IQYLKSM..AFSVYCQCR...RPLPTQI
 1705- 1732 (29.17/10.90)	IKSLTGFgpAASIEMTLKnpeRPSPIQL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.08|      17|     136|    1636|    1653|       9
---------------------------------------------------------------------------
 1636- 1653 (26.88/25.32)	WLLSLMRCyTEMLDNLPE
 1659- 1675 (31.20/22.60)	FILQIVPC.QYMLQTMKD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.34|      12|      27|    1810|    1821|      10
---------------------------------------------------------------------------
 1810- 1821 (24.58/14.17)	KIGLQKLWEWCI
 1840- 1851 (22.75/12.56)	RLGHGELKDWSI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      99.53|      27|     902|     174|     211|      11
---------------------------------------------------------------------------
  176-  202 (52.66/47.10)	WQYFYPMVLKKKEESKEEDE........LGYDDDF
 1296- 1330 (46.87/18.55)	WQQFHKMAGRGTYGSEESPEplpiptllVGYDKDF
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28168 with Med13 domain of Kingdom Metazoa
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