<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28164

Description Mediator complex subunit 25
SequenceMGGGGESCSLIAEGLSTALQLFDDFKKMREQIGQTHRVCLLICNSPPYLLPAVESTTYSGCTTENLVQQIGERGIHFSIVSPRKLPALRLLFEKAAPPALLEPLQPLTDVSQDPRHMVLVRGLVLPVGGGSAPGPLQSKQPVPLPPAAPSGAALSAAPQQPLPPVPPQYQVPGNLSAAQVAAQNAVEAAKNQKAGLGPRFSPITPLQQAAPGVGPPFSQAPAPQLPPGPPGAPKPPPASQPSLVSTVAPGSGLAPTAQPGAPSMAGTVAPGGVSGPSPAQLGAPALGGQQSVSNKLLAWSGVLEWQEKPKPASVDANTKLTRSLPCQVYVNHGENLKTEQWPQKLIMQLIPQQLLTTLGPLFRNSRMVQFHFTNKDLESLKGLYRIMGNGFAGCVHFPHTAPCEVRVLMLLYSSKKKIFMGLIPYDQSGFVNGIRQVITNHKQVQQQKLEQQQRGMGGQQAPPGLGPILEDQARPSQNLLQLRPPQPQPQGTVGASGATGQPQPQGTAQPPPGAPQGPPGAASGPPPPGPILRPQNPGANPQLRSLLLNPPPPQTGVPPPQASLHHLQPPGAPALLPPPHQGLGQPQLGPPLLHPPPAQSWPAQLPPRAPLPGRCSGLRGTGSHRSLLTWAHPRGSGRERAPAQQQAAGLERRPRVAGEAQTLL
Length664
PositionUnknown
OrganismGorilla gorilla gorilla (Western lowland gorilla)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini> Hominidae> Gorilla.
Aromaticity0.04
Grand average of hydropathy-0.344
Instability index60.87
Isoelectric point9.97
Molecular weight69342.93
Publications
PubMed=22398555

Function

Annotated function 
GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP28164
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     419.57|      62|      62|     445|     506|       1
---------------------------------------------------------------------------
  121-  184 (48.57/ 8.53)	..................RG.LvlpvGG........GS.A....P...GP....LQSKQpvplppAAPSGAALSAAPQQPlppvPPQYQVPGNLSAAQVAAQN
  187-  237 (67.39/15.61)	E....AAK.......NQKAG.L....GPrfspitplQQ.A....APGVGP....PFS.Q......A.PAPQL....PPGP.....P....GA......PKPPP
  369-  444 (44.75/ 7.09)	QfhftNKD..LEslkGLYRI.M....GN........GF.AgcvhFPHTAPcevrVLMLL......YSSKKKIFMGLIPYD....Q.SGFVNGIRQVITNHKQV
  445-  506 (111.78/32.31)	Q....QQK..LE...QQQRG.M....GG........QQ.A....PPGLGP....ILEDQ......ARPSQNLLQLRPPQP....QPQGTVGASGATGQPQPQG
  507-  562 (79.15/20.03)	T....AQP..PP...GAPQGpP....GA........AS.G....PPPPGP....ILRPQ...npgANPQLRSLLLNP..P....PPQ........TGVPPPQA
  570-  622 (67.94/15.82)	P....GAPalLP...PPHQG.L....GQ........PQlG....PPLLHP....P.PAQ......SWPA....QLPPRAP....LPGRCSGLRG.TG......
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      85.88|      20|      20|     247|     266|       2
---------------------------------------------------------------------------
  241-  261 (33.64/12.07)	PSLVS......tVAPG..SG.LAPTAQPGA
  262-  283 (27.86/ 8.66)	PSMAG......tVAPGgvSG.PSP.AQLGA
  284-  311 (24.38/ 6.60)	PALGGqqsvsnkLLAW..SGvLEWQEKPKP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.47|      20|      35|      30|      52|       3
---------------------------------------------------------------------------
   30-   52 (29.33/21.45)	EQIGQtHRVCLLICNspPYLLPA
   68-   87 (35.14/15.48)	QQIGE.RGIHFSIVS..PRKLPA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28164 with Med25 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GSAPGPLQSKQPVPLPPAAPSGAALSAAPQQPLPPVPPQYQVPGNLSAAQVAAQNAVEAAKNQKAGLGPRFSPITPLQQAAPGVGPPFSQAPAPQLPPGPPGAPKPPPASQPSLVSTVAPGSGLAPTAQPGAPSMAGTVAPGGVSGPSPAQLGAPALG
2) HKQVQQQKLEQQQRGMGGQQAPPGLGPILEDQARPSQNLLQLRPPQPQPQGTVGASGATGQPQPQGTAQPPPGAPQGPPGAASGPPPPGPILRPQNPGANPQLRSLLLNPPPPQTGVPPPQASLHHLQPPGAPALLPPPHQGLGQPQLGPPLLHPPPAQSWPAQLPPRAPLPGRCSGLRGTGSHRSLLTWAHPRGSGRERAPAQQQAAGLERRPRVAGEAQTLL
130
441
287
664










Molecular Recognition Features






MoRF SequenceStartStop




1) HRSLLTWAHPR
2) QAAGLERRPR
624
646
634
655