<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28160

Description Mediator of RNA polymerase II transcription subunit 1
SequenceMKAQGETEESEKLSKMSSLLERLHAKFNQNRPWSETIKLVRQVMEKRVVMSSGGHQHLVSCLETLQKALKVTSLPAMTDRLESIARQNGLGSHLSASGTECYITSDMFYVEVQLDPAGQLCDVKVAHHGENPVSCPELVQQLREKNFDEFSKHLKGLVNLYNLPGDNKLKTKMYLALQSLEQDLSKMYYVSPSDLLDDKTASPIILHENNVSRSLGMNASVTIEGTSAVYKLPIAPLIMGSHPVDNKWTPSFSSITSANSVDLPACFFLKFPQPIPVSRAFVQKLQNCTGIPLFETQPTYAPLYELITQFELSKDPDPIPLNHNMRFYAALPGQQHCYFLNKDAPLPDGRSLQGTLVSKITFQHPGRVPLILNLIRHQVAYNTLIGSCVKRTILKEGTAFPLICLLEDGNLLLQLHHCTPTWVTQCMSIPVTMRAIRRKAETIQADTPALSLIAETVEDMVKKNLPPASSPGYGMTTGNNPMSGTTTPTNTFPGGPITTLFNMSMSIKDRHESVGHGEDFSKVSQNPILTSLLQITGNGGSTIGSSPTPPHHTPPPVSSMAGNTKNHPMLMNLLKDNPAQDFSTLYGSSPLERQNSSSGSPRMEICSGSNKTKKKKSSRLPPEKPKHQTEDDFQRELFSMDVDSQNPIFDVNMTADTLDTPHITPAPSQCSTPPTTYPQPVPHPQPSIQRMVRLSSSDSIGPDVTDILSDIAEEASKLPSTSDDCPAIGTPLRDSSSSGHSQSTLFDSDVFQTNNNENPYTDPADLIADAAGSPSSDSPTNHFFHDGVDFNPDLLNSQSQSGFGEEYFDESSQSGDNDDFKGFASQALNTLGVPMLGGDNGETKFKGNNQADTVDFSIISVAGKALAPADLMEHHSGSQGPLLTTGDLGKEKTQKRVKEGNGTSNSTLSGPGLDSKPGKRSRTPSNDGKSKDKPPKRKKADTEGKSPSHSSSNRPFTPPTSTGGSKSPGSSGRSQTPPGVATPPIPKITIQIPKGTVMVGKPSSHSQYTSSGSVSSSGSKSHHSHSSSSSSSASTSGKMKSSKSEGSSSSKLSSSMYSSQGSSGSSQSKNSSQSGGKPGSSPVTKHGLSSGSSSTKMKPQGKPSSLMNPSLSKPNISPSHSRPPGGSDKLASPMKPVPGTPPSSKAKSPISSGSGGSHMSGTSSSSGMKSSSGLGSSGSLSQKTPPSSNSCTASSSSFSSSGSSMSSSQNQHGSSKGKSPSRNKKPSLTAVIDKLKHGVVTSGPGGEDPLDGQMGVSTNSSSHPMSSKHNMSGGEFQGKREKSDKDKSKVSTSGSSVDSSKKTSESKNVGSTGVAKIIISKHDGGSPSIKAKVTLQKPGESSGEGLRPQMASSKNYGSPLISGSTPKHERGSPSHSKSPAYTPQNLDSESESGSSIAEKSYQNSPSSDDGIRPLPEYSTEKHKKHKKEKKKVKDKDRDRDRDKDRDKKKSHSIKPESWSKSPISSDQSLSMTSNTILSADRPSRLSPDFMIGEEDDDLMDVALIGN
Length1506
PositionMiddle
OrganismGorilla gorilla gorilla (Western lowland gorilla)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini> Hominidae> Gorilla.
Aromaticity0.04
Grand average of hydropathy-0.710
Instability index54.42
Isoelectric point8.90
Molecular weight160300.81
Publications
PubMed=22398555

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP28160
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|    1079.98|     155|     155|     959|    1113|       1
---------------------------------------------------------------------------
  467-  635 (154.98/32.79)	P....................A.S.....SPGYGMTTGNN....PmsGTTTPtntfPGGPITtlfnmsMSIKDRHE..SVGHGEDFSkvsqnpiltsllQI.......T..GNGgsTIGSSPTPP........HHTPPPVSSM...AGNTKNHpmlmnlLKDNP....AQD.......F...STLY......GSSplERQNS......SSG....SP.....RMEI.CSG................SNKTKKKkssrlPPEK.PK.HQTEDDFQR
  636-  800 (164.69/35.28)	ElfsmdvdsqnpifdvnmtadT.LDTPHITPAPS.QCSTP....P..TTYPQ....PVPH...........PQPSIqrMVRLSSSDS............IG.......P..DVT..DILSDIAEE........ASKLPSTSDD...CPAIGTP......LRDSS....SSGHSQSTLfD...SDVF..QTNNNEN..PYTDPAdliaDAAGSPSSDSPT...NHFF.HDG............................VDFN.P..DLLN.SQSQ
  806-  958 (150.41/31.62)	E....................Y.FDESSQ....SGDNDDF....K..GFASQ....ALN..T......LGVP......MLGGDNGET............KFkgnnqadT..VDF..SIISVAGKAlapadlmeHHSGSQGPLL...TTGDLGK......EKTQKrvkeGNGTSNSTL.S...GPGLDSKPGKRSR..TPSNDG....KSKDKP...P.K...RK..........................KAD.....TEGKsPShSSSNRPFTP
  959- 1113 (266.53/61.42)	P....................T.STGGSKSPGSSGRSQTP....P..GVATP....PIPKIT......IQIPKGTV..MVGKPSSHS............QY.......T..SSG..SVSSSGSKS........HHSHSSSSSS...SASTSGK......MKSSK....SEGSSSSKL.S...SSMYSSQGSSGSS..QSKNSS....QSGGKPGSSPVT...KHGL.SSG................SSSTKMK.....PQGK.PS.SLMNPSLSK
 1114- 1273 (172.69/37.33)	P....................NiSPSHSRPPGGSDKLASPmkpvP..G..TP....PSSK...........AKSPI..SSGSGGSH.........................MSG..TSSSSGMKS........SSGLGSSGSL...SQKTPP.........SSN....SCTASSSSF.SssgSSMSSSQNQHGSS..KGKSPS....RN.KKPSLTAVIdklKHGVvTSGpggedpldgqmgvstnSSSHPM............S.SKHN..MSG
 1289- 1427 (170.68/36.82)	K....................V.STSGS.SVDSSKKTSES....K..NVGST....GVAKII......ISKHDG......GSPSIKA............KV.......TlqKPG..ESSGEGLRP........QMASSKNYGSpliSGSTPKH......ERGSP....SH.SKSPAY.T...PQNLDSESESGSS..IAEKSY....Q...................NSP................SSDDGIR.....PLPE.YS.TEKHKKHKK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.07|      24|      78|     105|     134|       2
---------------------------------------------------------------------------
  105-  134 (33.97/37.47)	SDMFYVevqlDPAgQLCDVKVAH....HgENPVS
  185-  212 (40.11/22.94)	SKMYYV....SPS.DLLDDKTASpiilH.ENNVS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     111.04|      26|      26|     276|     301|       3
---------------------------------------------------------------------------
  259-  285 (29.38/14.80)	.NSV....DLPacFFLKFPQPI..PVSRA....FVQ.KL
  286-  312 (39.86/22.89)	QNCT....GIP..LFETQPTYA..PLYEL....ITQfEL
  314-  334 (21.17/ 8.47)	KDPD....PIP..LNHNMRFYAalPGQ............
  335-  360 (20.63/ 8.05)	QHCYflnkDAP..L..........PDGRSlqgtLVS.KI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.68|      16|      40|     370|     388|       5
---------------------------------------------------------------------------
  370-  388 (18.85/23.72)	LILNLirHQVAyNTLIGSC
  411-  426 (32.83/22.53)	LLLQL..HHCT.PTWVTQC
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28160 with Med1 domain of Kingdom Metazoa
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