<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28152
Description |
Mediator of RNA polymerase II transcription subunit 8 |
Sequence | VQREEKQLEASLDALLSQVADLKNSLGSFICKLENEYGRLTWPSVLDSFALLSGQLNTLNKVLKHEKTPLFRNQVIIPLVLSPDRDEDLMRQTEGRVPVFSHEVVPDHLRTKPDPEVEEQEKQLTTDAARIGADAAQKQIQSLNKMCSNLLEKISKEERESESGGLRPNKQTFNPTDTNALVAAVAFGKGLSNWRPSGSSGPGQAGQPGAGTILAGTSGLQQVQMAGAPSQQQPMLSGVQMAQAGQPGKMPSGIKTNIKSASMHPYQRPSCLGFILAIRLRRKVKKLLGQEGKKKCPPAALVKLGPALLSIL |
Length | 312 |
Position | Head |
Organism | Gorilla gorilla gorilla (Western lowland gorilla) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia>
Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini> Hominidae>
Gorilla.
|
Aromaticity | 0.04 |
Grand average of hydropathy | -0.406 |
Instability index | 48.45 |
Isoelectric point | 9.39 |
Molecular weight | 33768.45 |
Publications | PubMed=22398555
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364144
|
GO - Cellular Component | core mediator complex GO:0070847 IBA:GO_Central
mediator complex GO:0016592 IBA:GO_Central
|
GO - Biological Function | RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IBA:GO_Central
transcription coregulator activity GO:0003712 IBA:GO_Central
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IBA:GO_Central
|
Interaction
Repeat regions
Repeats |
>MDP28152
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 76.18| 25| 28| 67| 92| 1
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67- 92 (40.28/33.54) KTPLFRNQViIP..LVLSPDRD.EDLMRQ
96- 123 (35.90/24.43) RVPVFSHEV.VPdhLRTKPDPEvEEQEKQ
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 69.40| 14| 33| 229| 242| 3
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229- 242 (25.01/15.98) PSQQQPMLSGVQMA
251- 264 (21.37/12.58) PSGIKTNIKSASMH
265- 277 (23.01/14.11) PYQRPSCL.GFILA
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