<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28142

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMSSCYVPNGASLEDCHSNLFCLADLTGIKWKRFVWQGPTSAPILFPVTEEDPILCSFSRCLKADVLSVWRRSQRPGRRELWLFWWGDDPNFADLIHHELAAEDDGLWENGLSYECRTLLFKAIHNLLERCLMNRSFVRIGKWFVKPYEKDEKPINKSEHLSCAFTFFLHGESNVCTSVEINQHQPVYHLTEEHLTLAQQSSSPFQVILSPFGLNGTLTGQSFKMSDPPTKKLIEEWNQFYPISPSAKDGVSEDKAEDMDWEDDCLASVEVLVGGVRMLYPACLVLVPQSDIPVVAPVGSSHCTAVYSGGHQVPASQREPAMSLVTLTPPTSPEEAHTVDSHLAQKWVKMPSSSDAFTVDTTSHHGGKIPRRQASQVVERVWQECNIDRAQNKRKFSAATNGTCEEERAEKAGAWDFVKHSQRSYCNCSRYKSVKQRTASTPGQTPSVGQTCQTPTKHKAGGEKPEKGDKLQKRPQTPFHHRSLTSDDVSMEAEASAGQRLAMTGQDGGRFPSIRSTDVSSIQKASQLHSGGISAGPSEQANSPQPPPLSPHPCERGEESVEGMKNPSTPNSQHFYQLPPEPCLVGVKGGSEGHGGPEGLNQHFHSHHPHSHPGASTYSDPPEPTVYVSAAVNLEEDGTHSPWRLFNLPRRKEAELPTPLLPWDKLRDEPLSSQDNLVSVTEVMSTSKWPLKVSEERVQMYRARRNQFLSAAITDGDHEPEVDPYAFEEGDVKFTFSNKKDKAGGEREPGKKHKVSPAEGGATQLDLIKKEDCVNLLSEDKSDAQRAAAHNRMASTSLIHETDLVVSINDLDNLFNSDEDESAPGSRRPVNGTDERFAGKEPKPSTLDPVSCISSADLHQMFPTPPSLEQHIMGYSPMNMFSKEYSMEANTGMTMLDGTSSLGGHFKIEVEESFCSPKPCEIKDYSFVYKPELCQPFVGCSMFAPLKALPSQCLPPVKIPEDCIYRPSWTMGREMLNPVPVMTFLNKDCNIPSVGSTMDQDYNQTYTPQTHTPFISNSAPPSNSGAGILPSPATPRFSAPTPRTPRTPRTPRGPSSVQGSLKYENSDLYSPASTPSTCRPLNSVEPATVPSIPEAHSLYVTLILSESVMNLFKDCNFDSCCICVCNMNIKGADVGVYLSDPVGEAQDPCSCGFSAMVNRRYGNGSGLFLEDELDIIGRGSDVSREAEKRFEALRLSSLERTGVGRGDRVPDEVILLLQDQCTNPFSPISILEHDIVSRGPSGAPVPPCVRVEERDYHSDCYMALEHGRQFMDNMSGGKVDESLVKSTCLHHWGKQNAVDVTALCSQDVLRVLMSLQPILQDAIQKKRTVRSWGVQGPLTWQQFHKMAGRGSYGTDESPEPLPIPTFLVGYEYDFVVLSPFGLPYWEKLLLDPFGSQRDIGYLVVCPDNEALLSGAKGFFRDLTAVYESCRLGQHRPISKGYPDGIVLVGGNGANNLVDQPVSDWFLKAASSNSEAFTKLKLYAQVCRHNLAPYLASQPLDSSLLTQPSLPPSSSQSPSTQLSSSTSSSVGQQGSVNAAGSSVTGSGNGTASSNSLVTSLGQPCSGTPSAKPSSFPPFGSTQSQGGGPQSGQLGQQAGTLNTGTSGENSSSQSQGPTEPPESTLERDKIGMPTDGESHAITYPPAIVVYIVDPFSYDEADGGPGPVPAHSSVWTLGLLRCYLEMLQFLPPHIRNSISVQIVPCQYLLQPVRGEDRHIYAQHLKSLAFSVFAQCRRPLPTSTNVKSLTGFGPGLAIDTALKSPERPECLRLYTPPFILAPVKDKQTELGETFGEASQKYNVLFVGYCLSHDQRWILATCTDLYGELLETCIINIDVPNRARRKKGSVRRLGLQKLWDWCLGLVQMTSVPWRVVIGRLGRIGHGELKDWSILLSRRNLQSLSRRLKEMCRMCGISASDTPSILSVCLVAMEPQGSFIIMPDSVSTGSVFGRSTTLNMQTSQLNTPQDTSCTHILVFPTSAFVQVASSNYTNIDPNIDILNGTSDGIFDLLDQENELVDPDIINISPNTSPVHSPGSHYHHGGDGSKGQSTDRMESHEEVPNLLQQPLALGYFVSTAKAGPLPDWFWSACPQAQNQCPLFLKASLHLHVSSVQSDELLHSKHSHPLDSNQTSDVLRYVLEQYNALSWLTCDPATQDRRSCLPIHFVVLNQMYNFIMNML
Length2174
PositionMiddle
OrganismGasterosteus aculeatus (Three-spined stickleback)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Neoteleostei> Acanthomorphata> Eupercaria> Perciformes> Cottioidei> Gasterosteales> Gasterosteidae> Gasterosteus.
Aromaticity0.07
Grand average of hydropathy-0.418
Instability index54.50
Isoelectric point5.69
Molecular weight238682.01
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364134

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP28142
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     134.73|      30|      31|     550|     579|       1
---------------------------------------------------------------------------
  550-  579 (61.98/32.75)	PHPCERG.EESVEGMKNPSTPNSQHF.............YQLPP
  581-  621 (34.15/14.34)	..PCLVGvKGGSEGHGGPEGLN.QHFhshhphshpgastYSDPP
 1074- 1098 (38.60/17.28)	PSTC.RP.LNSVEPATVPSIPEAHSL.............Y....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     154.32|      28|      28|    1559|    1586|       2
---------------------------------------------------------------------------
 1516- 1542 (24.99/ 6.16)	..PSTQLSSS..TSSSV.....GQQGSVNAAGS.SvT
 1559- 1586 (56.50/23.21)	GQPCSGTPSA..KPSSF.....PPFGSTQSQGG.G.P
 1592- 1614 (38.10/13.26)	GQQ.AGTLNT..GTSG.......ENSSSQSQ...G.P
 1628- 1663 (34.73/11.43)	GMPTDGESHAitYPPAIvvyivDPFSYDEADGGpG.P
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.04|      18|      28|    1842|    1859|       3
---------------------------------------------------------------------------
 1842- 1859 (35.56/20.73)	GSVRRLGLQKLWDWCLGL
 1872- 1889 (33.48/19.08)	GRLGRIGHGELKDWSILL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     548.46|     184|    1191|      12|     260|       4
---------------------------------------------------------------------------
   12-  260 (261.07/308.41)	LEDCHSNLFclADLTgIKWKRFVWQGPTSAPIlfP....VTEEDpilcSFSRCLKAdvLsvwrrsqRPGR................RELWLFWWGDDpNFADLIhhELAAEDdgLWENGLSYEcrTLLFKAIHNllERCLmnRSFVRIG..KW..FVK.....PYEKDEKPinksEHLSCAfTFFLHGESNVctsveinqhqpvyhlteehltlaqqssspfqVILSPFGL..........................NGTLTGQSFKMSDPPTKKLIEEWNQFYPISPSAKDG...VSEDKAEDM......DW
 1216- 1463 (287.39/182.17)	LQDQCTNPF..SPIS.ILEHDIVSRGPSGAPV..PpcvrVEERD....YHSDCYMA..L.......EHGRqfmdnmsggkvdeslvKSTCLHHWGKQ.NAVDVT..ALCSQD..VLRVLMSLQ..PILQDAIQK..KRTV..RSWGVQGplTWqqFHKmagrgSYGTDESP....EPLPIP.TFLVGYEYDF...............................VVLSPFGLpywekllldpfgsqrdigylvvcpdnEALLSGAKGFFRDLTAVYESCRLGQHRPISKGYPDGivlVGGNGANNLvdqpvsDW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     200.50|      37|      37|     985|    1021|       5
---------------------------------------------------------------------------
  918-  950 (41.40/19.34)	PCEI.........KDYSFVYKPEL.CQPFVGCSmfAPLK......alPS
  951-  986 (51.54/26.26)	QC.L.PPVKIPEDCIYRPSWTMGR.E...MLNP..VPVM.....tflNK
  987- 1023 (69.93/38.80)	DCNI.PSVGSTMDQDYNQTYTPQT.HTPFISNS..APPS........NS
 1024- 1065 (37.63/16.77)	GAGIlPSPAT...PRFSAP.TPRTpRTPR.TPR..GPSSvqgslkyeNS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      99.86|      29|      29|     467|     495|       6
---------------------------------------------------------------------------
  467-  495 (51.62/32.00)	GDKLQKRPQTPFHHRSLTSDDVSMEAEAS
  497-  525 (48.24/29.36)	GQRLAMTGQDGGRFPSIRSTDVSSIQKAS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.88|      24|      30|     715|     740|       7
---------------------------------------------------------------------------
  715-  740 (39.96/28.65)	GDHEP....EVDPYafEEGDVKFTFSNKKD
  744-  771 (35.92/19.18)	GEREPgkkhKVSPA..EGGATQLDLIKKED
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.88|      13|      37|    1159|    1171|       8
---------------------------------------------------------------------------
 1159- 1171 (23.83/16.11)	RYGNGSGLFLEDE
 1199- 1211 (23.05/15.26)	RTGVGRGDRVPDE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.16|      15|      37|     774|     791|       9
---------------------------------------------------------------------------
  774-  791 (20.26/19.15)	NLLsedKSDAQRAAAHNR
  812-  826 (26.90/15.76)	NLF...NSDEDESAPGSR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     122.52|      37|    1191|     828|     874|      10
---------------------------------------------------------------------------
  828-  864 (66.72/47.62)	PVNGTDERFAGKEPKPST.LDPVSCISS...ADLHQMFPTP
  876-  916 (55.80/22.59)	PMNMFSKEYSMEANTGMTmLDGTSSLGGhfkIEVEESFCSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.49|      18|      31|    1099|    1119|      12
---------------------------------------------------------------------------
 1099- 1119 (27.45/26.72)	VTLILSESVMNLFKDCnfdSC
 1133- 1150 (35.04/23.10)	VGVYLSDPVGEAQDPC...SC
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28142 with Med13 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DLDNLFNSDEDESAPGSRRPVNGTDERFAGKEPKPS
2) KQRTASTPGQTPSVGQTCQTPTKHKAGGEKPEKGDKLQKRPQTPFHHRSLTSDDVSMEAEASAGQRLAMTGQDGGRFPSIRSTDVSSIQKASQLHSGGISAGPSEQANSPQPPPLSPHPCERGEESVEGMKNPSTPNSQHFYQLPPEPCLVGVKGGSEGHGGPEGLNQHFHSHHPHSHPGASTYSDPPEPTVYVSAAVNL
3) PDIINISPNTSPVHSPGSHYHHGGDGSKGQSTDRMESHEEV
4) SSLLTQPSLPPSSSQSPSTQLSSSTSSSVGQQGSVNAAGSSVTGSGNGTASSNSLVTSLGQPCSGTPSAKPSSFPPFGSTQSQGGGPQSGQLGQQAGTLNTGTSGENSSSQSQGPTEPPESTLERDKIGMPTDGES
5) STMDQDYNQTYTPQTHTPFISNSAPPSNSGAGILPSPATPRFSAPTPRTPRTPRTPRGPSSVQGSLKYENS
809
434
2015
1500
995
844
633
2055
1635
1065










Molecular Recognition Features






MoRF SequenceStartStop




NANANA