<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28140

Description Mediator of RNA polymerase II transcription subunit 7
SequenceMGEPQQVSALPPPPMQYIKEYTDENIRKGLVPKPPPPIRDSYMMFGNQFQCDELIIRPLESQGIERLHPMQFDHKRELKKLNMSILVNFLDLLDILIKSPGSIKREEKLEDLKLLFVHMHHLINEYRPHQARETLRVMMEVQKRQRLETAERFHKHLERVVEMIQGCLASLPDDLPQMEGPDVAGEVPRSVSEGAGVGSSGQAPWLNTEPMDVEEAGASCMAAGHQDKIIPISKRDKLLDNNAAMCSIIDEIA
Length253
PositionMiddle
OrganismGasterosteus aculeatus (Three-spined stickleback)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Neoteleostei> Acanthomorphata> Eupercaria> Perciformes> Cottioidei> Gasterosteales> Gasterosteidae> Gasterosteus.
Aromaticity0.04
Grand average of hydropathy-0.453
Instability index48.56
Isoelectric point5.52
Molecular weight28744.94
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP28140
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.94|      14|      26|     127|     142|       2
---------------------------------------------------------------------------
  127-  142 (21.38/25.10)	RPHQAREtlRVMMEVQ
  152-  165 (25.56/20.85)	RFHKHLE..RVVEMIQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.09|      16|      26|      75|      92|       3
---------------------------------------------------------------------------
   75-   92 (21.28/21.00)	KRELKKLNMSILvnFLDL
  104-  119 (26.80/18.49)	KREEKLEDLKLL..FVHM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.86|      23|      26|      20|      45|       4
---------------------------------------------------------------------------
   20-   45 (39.85/30.48)	EY.TDENIRKglvPKPPPPI.RDSYMMF
   48-   72 (35.01/19.19)	QFqCDELIIR...PLESQGIeRLHPMQF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      71.30|      14|      14|     188|     201|       5
---------------------------------------------------------------------------
  172-  185 (24.19/14.30)	PDDLPQMEGPDVAG
  188-  201 (22.15/12.51)	PRSVSEGAGVGSSG
  204-  217 (24.96/14.97)	PWLNTEPMDVEEAG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28140 with Med7 domain of Kingdom Metazoa
Unable to open file!