<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28139

Description Mediator of RNA polymerase II transcription subunit 19
SequenceMTEMFSTLFGQNEAQGPGSSSLGFGPGKPPPPLPQNQVSMAGQMPPQLGDEGPTLRKPGAMNEPFYLLRELPVGNELTGNSNLITHYNLEHAFNKFCGKKVKEKLSNFLPELPGMIDCPGTQDGSSLRSLIDKPPVCGNSFSPLTGALLTGFRLHTGPLPEQYRLMHIQPPKKKSKHKHKHHRLQDPLPQETPSDTDPKKKKKKRDDDPDRKKKKKDKKKKKNRHSPAHPGLAGSQTNSHSLR
Length243
PositionHead
OrganismGasterosteus aculeatus (Three-spined stickleback)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Neoteleostei> Acanthomorphata> Eupercaria> Perciformes> Cottioidei> Gasterosteales> Gasterosteidae> Gasterosteus.
Aromaticity0.05
Grand average of hydropathy-1.041
Instability index48.77
Isoelectric point9.83
Molecular weight26921.56
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364151

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP28139
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      90.74|      25|      26|     158|     183|       1
---------------------------------------------------------------------------
  158-  183 (44.76/24.81)	PLPEQYRlMHIQPPKKKSKHKHKHHR
  187-  211 (45.98/21.89)	PLPQETP.SDTDPKKKKKKRDDDPDR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.36|      21|      24|      11|      31|       2
---------------------------------------------------------------------------
   11-   31 (41.17/19.04)	QNEAQGPGS..SSLG.FGPGKPPP
   35-   58 (30.19/12.21)	QNQVSMAGQmpPQLGdEGPTLRKP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.74|      18|      21|      97|     114|       3
---------------------------------------------------------------------------
   97-  114 (32.08/18.38)	C.GKKVKEKLSNFL..PELPG
  118-  138 (24.66/12.61)	CpGTQDGSSLRSLIdkPPVCG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28139 with Med19 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MFSTLFGQNEAQGPGSSSLGFGPGKPPPPLPQNQVSMAGQMPPQLGDEGPTLRKPGAM
2) PLPEQYRLMHIQPPKKKSKHKHKHHRLQDPLPQETPSDTDPKKKKKKRDDDPDRKKKKKDKKKKKNRHSPAHPGLAGSQTNSHSLR
4
158
61
243










Molecular Recognition Features






MoRF SequenceStartStop




1) DPKKKKKKRDDDPDRKKKKKDKKKKKNRHSPAH
2) FYLLR
3) KHKHKH
4) YRLMHIQ
197
65
176
163
229
69
181
169