<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28134

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMTTAANWVANGASLEDCHSNIFSLAELTGIKWRCYSFRGSGECGPVISSPAQDDPVLRSFMRCVQANLLCVWRRKVKPDAKELWIFWWGEEPRLSDVIHQELEVSEEGLWECGLSYECRTLLFKAIHNLLERCLMDKGFVRIGKWFFKPHELQEKSLGNSEHLSCSFSFFLHGESNVCTSVEIAQHQPAYHVTEHHVRLAQASVTPLQVILSPYGLSGTLTGQAFKMSDPATRKLMEEWSYFYPVVLPLREGSGEREKGEASQSYDRNCHAAVEVIVGGVRMTYPAALVLIAQGDLPLEQSPPVPATQGLSRELNHCSVPLTPPASPQQPCSGTDSGFVTSISNVPTPDSGMGVASASPKHSGKKLTSQVVQQAWRECYLTQPQHALNSHTGVSLKKDAPSGVTGWDFSDLGGRVSCSCSRLKQQKLNLTASANPQTSANPTQSSGVSLYPPSLPKHKTSDKTEKADKQSKRPAVTSFHHRLSVSRETPLEQDPAGGPQLGGLVALEPPSEPPSALPSCKYPKLLPNGRKAPESLLHSPMSPLPPTLSPHPRVQDPEVLGGPADVPLCQDGAAGLGLIASETAVYTALLRQRENGAGWWRGFRTPRTDETDCRPCELPTDVLEEVKTEAATEGALLKRLYTQTHKRFKISEERVRDHIHTLGLFQQSGVEVLREPGEDPYDFKEGDIEYTFSSSKRLKGQGREPSKKAKSYFLHQGEEITSNGALPDGNDAMSIFNSAPKSEESGQDADGAAKANPSLTREKDLVVNISDLDNIFDEDEEELGTVYPNQHSSKLPVSTEDRPLGKEGRVAVPYPSTVADLQRMFPTPPSLEQHPAFSPATTYRDTPSQEPPVHSGAADHLLPLASSQFTEYRMEMDEGLASPGMEDLKIFSTHIFSIQPQIGSSMFAPLSCLPSQSLPPLKITEQCYYRPSWALLPKMEHFPLMHSHNTTFNRDGYTNVPSVNTLMDQEYGQMSTTTASVSTNAGILPSPATPRFSVPTPRTPRTPRGVNAASSGQGSVKQDGTELSSPVSTPSTSLPLSSVDPLARPGPSLPEAHSLYAILLLSDSVLNVFKDRNFDSCCICACNMNVKGADVGVYIPDSTCEDQYRCMCGFSAIVNRRLAHGTGLFLEDELDIYGRTSEVGRAAERRLALCRRDPSMGDTRAKRAQDAAPASPLVMILLQEHCSQPISSFASLHLPLSCSCHGRMGALLQSWTSEKQWADGSDACVDCYNALEQGLQYVDNSTGGKVDPAVVRSTALHSWPHTNVADMNMLSSQDMVRMLLSLQPFLQDAIQKKRSGRTWENIQHVQGPLTWQQFHKMAGRGSYGSEESPEPLPIPTVLLGYDRDFLALSPLALPFWEKLLLEPYGGSRDVAYVVLCPSSPSLLAAARAFFQELSAVYETCRLGKHRPLAKVSMDGLVRVGEEVEAEKLEALGVDQWVTGPWAGQQHSDNLSKLKLYAYACKQQLGPQLSALPLDSSLLLPPKVQPPSHPAPSAQPASSGQPQAWGPDGGPAPGAVSSANASTPTAATSNQTGETAQGALSDPKGPPGATPPTNTPAENPELNPINISTFKYRPACFHLCFLSCSLSTAEQSRIGIPTVADSMDSLANPPAIVIYIVDAFLSSSGARNEGGDIWLLGLLRCYTEMLKTLPETMRPALVLQVVPCQYLLQPASGESHFYLQHLRSLSFSCYSQCRRLLPQQTPIKSLTGFGPVSNVNSVLKSPEHPSPLQLYTPPFILGPTRSKPPEPGEIWAELPPKYNVLFVGYCLSHDQRWILVSCTDQQGELLETSIINIDVPNRARRPKVSARKMGLQKLWEWCIGIIQMTSLPWRIVIGRLGRLGHGELKDWSSLLGEHSLHSIGRQLREACRMCGISAADSPSILSACLVAMEPQGSFVIMPDAVTMGSVFGRSTALNLQTSQLNTPQDASCTHILVFPTSATTQLAPSSYPTEDNNDDMFDLPFPDELENDIGHDMMLITGNLHPSPNTSPVPSPGSPSGMGMGSHFQHTKTQNQGERLMSRDSPPEELKQQPLALGYYVSTAQASGLPHWFWASCPQAESQCPLFLKASLHHHISIAQTDELASDKTKRPPHPLDSKKTSDVLRFVLEQYNALSWLTCSPATQDRQSCLPVHLAVLIQMYNAILNML
Length2147
PositionMiddle
OrganismGasterosteus aculeatus (Three-spined stickleback)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Neoteleostei> Acanthomorphata> Eupercaria> Perciformes> Cottioidei> Gasterosteales> Gasterosteidae> Gasterosteus.
Aromaticity0.07
Grand average of hydropathy-0.343
Instability index56.61
Isoelectric point5.92
Molecular weight234393.85
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364134

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP28134
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     220.04|      56|      94|     346|     402|       1
---------------------------------------------------------------------------
  346-  402 (93.65/54.37)	PTPDSGMGVASAS.PKHSGKKLTSQVVQQAWRECYLTQPQHALNSHTGVSLKKDaPSG
  404-  438 (38.96/16.11)	....TGWDFSDLG.GRVSCS..CSRLKQQKLNLTASANPQTS................
  441-  496 (87.43/46.77)	PTQSSGVSLYPPSlPKHKTSDKTEKADKQSKRPA.VTSFHHRLSVSRETPLEQD.PAG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     244.06|      63|      63|    2000|    2062|       2
---------------------------------------------------------------------------
 1964- 1998 (45.11/17.58)	...........................PDELEND...IGHDMMLITGNLHPSPNTSPV.P..SPGSPS
 2000- 2062 (113.09/55.46)	MGMGSHFQHTKTQNQGERLMSRDS..PPEELKQQPLALGYYVSTAQASGLPHWFWASC.P..QAESQC
 2064- 2128 (85.86/40.28)	LFLKASLHHHISIAQTDELASDKTkrPPHPLDSKKTSDVLRFVLEQYNALS...WLTCsPatQDRQSC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     622.60|     203|     234|    1292|    1518|       3
---------------------------------------------------------------------------
  818-  919 (41.92/10.00)	ADlQRMFPTP..PSLEQHP....................................................................................................................................................................................afspattyrdtpsqeppvhsgaadhllplassqfteyrmemdeglaSPGMEDLKIFSthiFSIQPQ...IGSSMFA.PLSclPSQSLPP...................
 1292- 1497 (276.49/138.18)	...............................AIQKKRSGRTweniqhVQGPLTWQQFHKMAGRGSYGSEESPEPLPIPTVLLGYdRD......FLALSpLALPFWEKLLLEPYGGSRDvayvVLCPSSPSLLAAARAFFQELSAVYETCR...LGkhrpLAKVSMDGLVRVGEEVE.AEKLEALGVdQWVTGPWAGQQH..............................................SDNLSKLKLYA...YACKQQ...LGPQLSAlPLD..SSLLLPP......KVQPPSHPAPsAQ
 1498- 1731 (304.18/125.10)	PA.SSGQPQAwgPDGGPAPgavssanastptAATSNQTGET......AQGALSDPKGPPGATPPTNTPAENPELNPINISTFKY.RPacfhlcFLSCS.LSTAEQSRIGIPTVADSMD....SLANPPAIVIYIVDAFLSSSGARNEGGDiwlLG....LLRCYTEMLKTLPETMRpALVLQVVPC.QYLLQPASGESH..............................................F.YLQHLRSLS...FSCYSQcrrLLPQQT..PIK..SLTGFGPvsnvnsVLKSPEHPSP.LQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     163.14|      52|     283|     715|     777|       4
---------------------------------------------------------------------------
  720-  772 (82.78/64.67)	TSNGALPDGNDA.MSIFNSAPKSEESGQDADGaAKANPSLTREKDL....VVNISDLD
 1215- 1271 (80.36/38.59)	TSEKQWADGSDAcVDCYNALEQGLQYVDNSTG.GKVDPAVVRSTALhswpHTNVADMN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     158.96|      34|     283|     499|     532|       5
---------------------------------------------------------------------------
  499-  532 (60.06/29.00)	QLGGLVALEPPSEPPSALPSCKYPKLLPNGRKAP
  985- 1012 (43.65/18.61)	...GI..LPSPATPRFSVPTPRTPR.TPRGVNAA
 1020- 1053 (55.25/25.95)	KQDGTELSSPVSTPSTSLPLSSVDPLARPGPSLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     128.12|      39|     495|     594|     656|       8
---------------------------------------------------------------------------
  601-  642 (59.85/76.22)	GFRTPRTDETDCRPCELPTDvLEEVKTEAATEGAllKRLYTQ
  662-  700 (68.27/29.34)	GLFQQSGVEVLREPGEDPYD.FKEGDIEYTFSSS..KRLKGQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     113.28|      35|    1692|     142|     230|       9
---------------------------------------------------------------------------
  144-  183 (56.15/108.44)	KW.FFKP..HELQEKSlGNSEHLSCSFSFflhgESNVCTSVEI
  238-  275 (57.13/12.10)	EWsYFYPvvLPLREGS.GEREKGEASQSY....DRNCHAAVEV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.07|      17|     867|     316|     332|      12
---------------------------------------------------------------------------
  316-  332 (37.31/19.62)	HCSVPLTPPASPQQP..CS
 1184- 1202 (30.76/14.62)	HCSQPISSFASLHLPlsCS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.18|      13|    1190|     544|     557|      14
---------------------------------------------------------------------------
  544-  557 (23.13/14.16)	PP.TLSPhPRVQDPE
 1735- 1748 (23.05/ 8.93)	PPfILGP.TRSKPPE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28134 with Med13 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DEDEEELGTVYPNQHSSKLPVSTEDRPLGKEGRVAVP
2) GHDMMLITGNLHPSPNTSPVPSPGSPSGMGMGSHFQHTKTQNQGERLMSRDSPPEE
3) KLNLTASANPQTSANPTQSSGVSLYPPSLPKHKTSDKTEKADKQSKRPAVTSFHHRLSVSRETPLEQDPAGGPQLGGLVALEPPSEPPSALPSCKYPKLLPNGRKAPESLLHSPMSPLPPTLSPHPRVQDPEVLGGPADVP
4) LPLDSSLLLPPKVQPPSHPAPSAQPASSGQPQAWGPDGGPAPGAVSSANASTPTAATSNQTGETAQGALSDPKGPPGATPPTNTPAENPELNP
5) LQRMFPTPPSLEQHPAFSPATTYRDTPSQEPPVHSGAADH
6) NRDGYTNVPSVNTLMDQEYGQMSTTTASVSTNAG
7) QSPPVPATQGLSRELNHCSVPLTPPASPQQPCSGTDSGFVTSISNVPTPDSGMGVASASPKHSGKKLT
8) REPSKKAKSYFLHQGEEITSNGALPDGNDAMSIFNSAPKSEESGQDADGAAKANPSLTREKD
9) SPATPRFSVPTPRTPRTPRGVNAASSGQGSVKQDGTELSSPVSTPSTSLPLSSVDPLARP
776
1972
426
1474
820
952
300
702
989
812
2027
566
1566
859
985
367
763
1048










Molecular Recognition Features






MoRF SequenceStartStop




NANANA